http://www.cnr.it/ontology/cnr/individuo/prodotto/ID109123

Osteopontin: A possible marker of vascular damage. (Abstract/Poster in atti di convegno)

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Osteopontin: A possible marker of vascular damage. (Abstract/Poster in atti di convegno) (literal)

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Del Ry S.; Maltinti M.; Colotti C.; Prontera C.; Rizza E.; Mazzone A.; Emdin M.; Giannessi D.; Neglia D. (2007)
Osteopontin: A possible marker of vascular damage.
in International Symposium Integrated Biomarkers in Cardiovascular Diseases, Berlino
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Del Ry S.; Maltinti M.; Colotti C.; Prontera C.; Rizza E.; Mazzone A.; Emdin M.; Giannessi D.; Neglia D. (literal)

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In: International Symposium Integrated Biomarkers in Cardiovascular Diseases (Berlino, 21-23 June 2007). Proceedings, pp. 0 - 0. ., 2007. (literal)

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Dilated cardiomyopathy (DCM) is a cardiac muscle disease characterized by reduced contractile function and dilation of the left or both ventricular chambers. Different clinical studies have demonstrated a clear impairment of coronary endothelial function in DCM as a part of a systemic alteration of the vascular endothelium. Endothelial dysfunction is able to strongly limit the coronary vasodilatory response to stress. An interesting observation is that up to 82% of DCM patients show reduced myocardial blood flow, at rest and during metabolic and pharmacological vasodilation, due to coronary microcirculatory dysfunction. DCM is associated with clinical, genetic and metabolic mechanisms; it is possibile to suppose a relation between endothelial/vascular and myocardic damage mechanisms and markers of coronary and myocardic microvascular function. Aim of this study was to measure, in DCM patients, the plasma levels of osteopontin (OPN), a extracellular matrix protein involved in the acute and chronic inflammatory vascular response, of B-type natriuretic peptide (BNP), a known marker of ventricular dysfunction as well as of other biomarkers in order to evaluate their relationship with coronary microvascular function, assessed by Positron Emission Tomography (PET). Biomarker plasma levels were studied in controls (n=64) and in DCM patients classified according to the ACC/AHA Guidelines: A) n=9, EF?50%, NYHA I; B) n=12, EF50%, NYHA I; C) n (literal)

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