Increase in plasma adrenomedullin after resynchronisation therapy in non responders at 6-month follow-up (Abstract in rivista)

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• Abstract in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Increase in plasma adrenomedullin after resynchronisation therapy in non responders at 6-month follow-up (Abstract in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Alternative label

• Del Ry S.; Morales M. A.; Startari U.; Maltinti M.; Prontera C.; Panchetti L.; Emdin M.; Giannessi D.; Piacenti M. (2006)
  Increase in plasma adrenomedullin after resynchronisation therapy in non responders at 6-month follow-up
  
  (literal)

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• Del Ry S.; Morales M. A.; Startari U.; Maltinti M.; Prontera C.; Panchetti L.; Emdin M.; Giannessi D.; Piacenti M. (literal)

Rivista

• Biochimica clinica (Rivista)

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• Biochimica Clinica, 30 351-351. Biomedia, 2006. (literal)

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• 2006 (literal)

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• Background: In patients (pts) with severe heart failure (HF) and left ventricular (LV) dyssynchrony, resynchronization therapy (CRT) may determine clinical benefits, inverse remodeling and reduction in plasma BNP. Other peptides, such as adrenomedullin (AM) are elevated in CHF; AM has a multi-tissue origin, being derived not only from heart and vessels but also from adrenal medulla and lung. Aim: to assess whether CRT induces changes in these neuropeptides and if these changes are related to clinical and functional parameters. Methods: A group of 23 pts in NYHA Class III-IV, complete left bundle branch block on baseline ECG and echocardiographic documentation of inter- and intra-ventricular dyssynchrony treated by CRT, were enrolled in the study. Clinical examination, 2D echo and AM and BNP assays were performed before device implantation and at 6-month follow-up (FU). Pts were divided in two groups, according to clinical parameters: Responders (Re) (16 pts): 1 NYHA Class improvement, no hospitalisation or increase in medication in the FU period and non responders (NRe) (6 pts): 1 NYHA Class improvement, at least 1 hospitalisation for worsening HF and increase in medication. The groups were comparable for age, cause of disease, type of medication and NYHA Class before implantation. Results: A significant increase in LVEF was observed only in Re (24.6±1.3% vs 28.9±1.8%, p0.05, NRe: 25.5±3.2% vs 27.1±3.1%, NS), together with a reduction in LVESD, as compared to baseline, (Re: 59±2 vs 53±3 mm, p0.05; NRe 56±3 vs 53±4 mm, NS). BNP level was reduced significantly only in Re (499±107 vs 193±63 pg/ml, p0.001; NRe 605±180 to 388±133 pg/ml, NS). A significant reduction in AM was found in Re from 29.1±3 to 18.6±1.6 pg/ml (p0.01), while AM significantly increased in NRe from 19.1±2 to 31.3±3.4 pg/ml (p0.05). Conclusions: Plasma BNP level are decreased significantly after CRT only in pts who show clinical improvement. AM level increase after CRT may likely indicate a compensatory neurohormonal response in NRe. Ref: Eto T, et al. Regulation of production and secretion of AM in the cardiovascular system. Regulatory Peptides 112: 61-69; 2003. (literal)

Note

• Abstract (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• ifc cnr (literal)

Titolo

• Increase in plasma adrenomedullin after resynchronisation therapy in non responders at 6-month follow-up (literal)

Prodotto di

• Tassonomia clinica molecolare - Tassonomia clinica molecolare (ME.P05.003.001) (Modulo)
• Istituto di fisiologia clinica (IFC) (Istituto)

Autore CNR

• MARIA AURORA MORALES (Unità di personale interno)
• DANIELA GIANNESSI (Unità di personale interno)
• SILVIA DEL RY (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Increase in plasma adrenomedullin after resynchronisation therapy in non responders at 6-month follow-up" (Insieme di parole chiave)

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Autore CNR di

• DANIELA GIANNESSI (Unità di personale interno)
• MARIA AURORA MORALES (Unità di personale interno)
• SILVIA DEL RY (Unità di personale interno)

Prodotto

• Istituto di fisiologia clinica (IFC) (Istituto)
• Tassonomia clinica molecolare - Tassonomia clinica molecolare (ME.P05.003.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biochimica clinica (Rivista)

Insieme di parole chiave di

• Parole chiave di "Increase in plasma adrenomedullin after resynchronisation therapy in non responders at 6-month follow-up" (Insieme di parole chiave)