Early post stress Tetrofosmin imaging improves sensitivity and specificity of SPECT: preliminary results of the Myoview Imaging Optimization (MIO) study (Abstract/Poster in atti di convegno)

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  • Early post stress Tetrofosmin imaging improves sensitivity and specificity of SPECT: preliminary results of the Myoview Imaging Optimization (MIO) study (Abstract/Poster in atti di convegno) (literal)
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  • 2006-01-01T00:00:00+01:00 (literal)
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  • Chiacchio S.; Giorgetti A.; Rossi M.; Gimelli A.; Ferdeghini E. M.; Kusch A.; D'Aragona Tagliavia I.; Marzullo P. (2006)
    Early post stress Tetrofosmin imaging improves sensitivity and specificity of SPECT: preliminary results of the Myoview Imaging Optimization (MIO) study
    in EANM'06 Annual Congress of the European Association of Nuclear Medicine, Atene, 30 Settembre - 4 Ottobre 2006
    (literal)
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  • Chiacchio S.; Giorgetti A.; Rossi M.; Gimelli A.; Ferdeghini E. M.; Kusch A.; D'Aragona Tagliavia I.; Marzullo P. (literal)
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  • S246 (literal)
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  • S246 (literal)
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  • 30 (literal)
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  • European Journal of Nuclear Medicine, 33 2 -. EANM. Springer, 2006. (literal)
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  • 1 (literal)
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  • AIM: to investigate whether early post stress Tetrofosmin imaging (T1) is feasible and more accurate than standard delayed imaging (T2) in detecting coronary artery disease. MATERIAL AND METHODS. 22 pts (18 male, 4 female, mena age 60+/-14 yrs) with anginal symptoms underwent single day stress-rest Tetrofosmin Gated SPECTR in pharmacological washout. T1 was obtained 15' and T2 45' after stress and rest injection with the same gamma camera and under the same acquisition parameters (180 degrees , 30 sec/frame). Ischemia was defined as reversible perfusion defect at visual semiquantitative analysis (4-points score scale from 0=normal to 4=severe hypoperfusion) in a 20-segments model. Coronary angiography was performed within one month in all patients and stenosis 50% at quantitative analysis were considered significant. Overall image quality was scored as optimal/good in 94% of T1 and 95% of T2. T1 sensitivity was significantly higher than T2 (100% vs 86%), similarly specificity was 86% for T1 and 57% of T2. In particular T1 and T2 resulted discrepant in 6 patients. T1 detected myocardial ischemia in 2 patients with coronary artery disease and negative T2. In 2 patients left ventricular stunning was evident only at T1 and in the last 2 patients T2 underestimated the extension of myocardial ischemia when compared to the vascular distribution of stenotic vessels. CONCLUSIONS: early Tetrofosmin stress and rest imaging is feasible and does not induce a deterioration of image quality. Early imaging shows an optimal accuracy in identifying coronary artery disease and defect size. Since ischemia recovers with time, T1 enhances the identification of patients with transient ventricular dysfunction after stress. All these findings suggest in some patients the occurrence of a significant redistribution of Tetrofosmin T1 to T2. Early post stress imaging can expand the diagnostic yield of Gated SPECT without detrimental defects on image quality (literal)
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  • CNR Fondazione \"G. Monasterio\" (literal)
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  • Early post stress Tetrofosmin imaging improves sensitivity and specificity of SPECT: preliminary results of the Myoview Imaging Optimization (MIO) study (literal)
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