A role for locus coeruleus in Parkinson tremor (Articolo in rivista)

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  • A role for locus coeruleus in Parkinson tremor (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.3389/fnhum.2011.00179 (literal)
Alternative label
  • Ioannis U.Isaias; Alberto Marzegan; Gianni Pezzoli; Giorgio Marotta; Margherita Canesi; Gabriele E.M. Biella; Jens Volkmann; Paolo Cavallari. (2012)
    A role for locus coeruleus in Parkinson tremor
    in Frontiers in human neuroscience
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Ioannis U.Isaias; Alberto Marzegan; Gianni Pezzoli; Giorgio Marotta; Margherita Canesi; Gabriele E.M. Biella; Jens Volkmann; Paolo Cavallari. (literal)
Pagina inizio
  • 179 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 5 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • Corresponding author: Ioannis U. Isaias (ioannis.isaias@unimi.it). IF 2010: 1.940 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dipartimento di Fisiologia Umana, Laboratorio Analisi del Movimento L.A.M.B., Università degli Studi di Milano, Milano. Centro per la Malattia di Parkinson e i Disturbi del Movimento, Istituti Clinici di Perfezionamento, Milano. Neurologische Klinik und Poliklinik, Universitätsklinik Würzburg, Würzburg (Germania). Dipartimento di Medicina Nucleare, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano. IBFM-CNR, Segrate (MI). (literal)
Titolo
  • A role for locus coeruleus in Parkinson tremor (literal)
Abstract
  • We analyzed rest tremor, one of the etiologically most elusive hallmarks of Parkinson disease (PD), in 12 consecutive PD patients during a specific task activating the locus coeruleus (LC) to investigate a putative role of noradrenaline (NA) in tremor generation and suppression. Clinical diagnosis was confirmed in all subjects by reduced dopamine reuptake transporter (DAT) binding values investigated by single photon computed tomography imaging (SPECT) with [(123)I] N-É-fluoropropyl-2²-carbomethoxy-3²-(4-iodophenyl) tropane (FP-CIT). The intensity of tremor (i.e., the power of Electromyography [EMG] signals), but not its frequency, significantly increased during the task. In six subjects, tremor appeared selectively during the task. In a second part of the study, we retrospectively reviewed SPECT with FP-CIT data and confirmed the lack of correlation between dopaminergic loss and tremor by comparing DAT binding values of 82 PD subjects with bilateral tremor (n = 27), unilateral tremor (n = 22), and no tremor (n = 33). This study suggests a role of the LC in Parkinson tremor. (literal)
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