What predicts cognitive decline in de novo Parkinson's disease? (Articolo in rivista)

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  • What predicts cognitive decline in de novo Parkinson's disease? (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Alternative label
  • Arnaldi D. 1, Campus C. 2, Ferrara M 1, Famà F. 1, Picco A. 1, De Carli F. 3, Accardo J. 1, Brugnolo A. 1, Sambuceti G. 4, Morbelli S. 4, Nobili F. 1,4 (2012)
    What predicts cognitive decline in de novo Parkinson's disease?
    in Neurobiology of aging
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Arnaldi D. 1, Campus C. 2, Ferrara M 1, Famà F. 1, Picco A. 1, De Carli F. 3, Accardo J. 1, Brugnolo A. 1, Sambuceti G. 4, Morbelli S. 4, Nobili F. 1,4 (literal)
Pagina inizio
  • 1127.e11 (literal)
Pagina fine
  • 1127.e20 (literal)
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  • 33 (literal)
Rivista
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  • Pubblicato on-line: 5 Gennaio 2012. Corresponding author: D. Arnaldi (dario.arnaldi@gmail.com) IF 2010: 6.634 (literal)
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  • 6 (literal)
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  • ISI Web of Science (WOS) (literal)
  • PubMe (literal)
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  • 1. Clinical Neurophysiology, Department of Neurosciences, Ophthalmology and Genetics, University of Genova. 2. Italian Institute of Technology (IIT), Genova. 3. IBFM-CNR, UOS Genova, Genova. 4. Nuclear Medicine, Department of Internal Medicine, University of Genova, Genova. (literal)
Titolo
  • What predicts cognitive decline in de novo Parkinson's disease? (literal)
Abstract
  • Subtle cognitive impairment can be detected in early Parkinson's disease (PD). In a consecutive series of de novo, drug-naive PD patients, we applied stepwise regression analysis to assess which clinical, neuropsychological, and functional neuroimaging (dopamine transporter [DAT] and perfusion single photon emission computed tomography [SPECT]) characteristics at baseline was predictive of cognitive decline during an average follow-up time of about 4 years. Decline both in executive (R(2) = 0.54; p = 0.0001) and visuospatial (R(2) = 0.56; p = 0.0001) functions was predicted by the couple of Unified Parkinson's Disease Rating Scale (UPDRS)-III score and caudate dopamine transporter (DAT) uptake in the less affected hemisphere (LAH). Verbal memory and language decline was predicted instead by caudate DAT uptake and brain perfusion in a posterior parieto-temporal area of the less affected hemisphere (R(2) = 0.42; p = 0.0005). No significant effect was shown for age, baseline neuropsychological scores, and levodopa equivalent dose at follow-up. The combined use of clinical structured examination and brain functional assessment by means of dual single photon emission computed tomography imaging appears as a powerful approach to predict cognitive decline in de novo PD patients. (literal)
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