Imaging intraplaque inflammation in carotid atherosclerosis with 11C-PK11195 positron emission tomography/computed tomography (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Imaging intraplaque inflammation in carotid atherosclerosis with 11C-PK11195 positron emission tomography/computed tomography (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1093/eurheartj/ehr367 (literal)

Alternative label

• Gaemperli O.1, Shalhoub J.2, Owen D.R.J. 1, Lamare F. 1, Johansson S. 3, Fouladi N. 3, Davies A.H. 2, Rimoldi E.O. 1,4, Camici P.G. 1,5 (2012)
  Imaging intraplaque inflammation in carotid atherosclerosis with 11C-PK11195 positron emission tomography/computed tomography
  in European heart journal
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Gaemperli O.1, Shalhoub J.2, Owen D.R.J. 1, Lamare F. 1, Johansson S. 3, Fouladi N. 3, Davies A.H. 2, Rimoldi E.O. 1,4, Camici P.G. 1,5 (literal)

Pagina inizio

• 1902 (literal)

Pagina fine

• 1910 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://eurheartj.oxfordjournals.org/content/33/15/1902.long (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 33 (literal)

Rivista

• European heart journal (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• Pubblicato on-line: 19 Settembre 2011 Corresponding author: P.G. Camici (camici.paolo@hsr.it) IF 2010: 10.046 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 15 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Medical Research Council, Clinical Sciences Centre and National Heart and Lung Institute, Hammersmith Hospital, London (UK). 2. Imperial Vascular Unit, Charing Cross Hospital, London (UK) 3. GE Healthcare, Medical Diagnostics, Amersham (UK) 4. CNR, Istituto Bioimmagini Fisiologia Molecolare, Segrate (MI). 5. Vita-Salute University and Scientific Institute San Raffaele, Milano. (literal)

Titolo

• Imaging intraplaque inflammation in carotid atherosclerosis with 11C-PK11195 positron emission tomography/computed tomography (literal)

Abstract

• Aims We sought to determine whether intraplaque inflammation could be measured with positron emission tomography/computed tomography angiography (PET/CTA) using 11C-PK11195, a selective ligand of the translocator protein (18 kDa) (TSPO) which is highly expressed by activated macrophages. Methods and results Patients (n = 32; mean age 70 ± 9 years) with carotid stenoses (n = 36; 9 symptomatic and 27 asymptomatic) underwent 11C-PK11195 PET/CTA imaging. 11C-PK11195 uptake into carotid plaques was measured using target-to-background ratios (TBR). On CTA images, plaque composition was assessed by measuring CT attenuation of the carotid plaque. Eight patients underwent carotid endarterectomy and ultrathin contiguous sections were processed for TSPO and CD68 (using immunohistochemical staining, 3H-PK11195 autoradiography, and confocal fluorescence microscopy). Carotid plaques associated with ipsilateral symptoms (stroke or transient ischaemic attack) had higher TBR (1.06 ± 0.20 vs. 0.86 ± 0.11, P = 0.001) and lower CT attenuation [(median, inter-quartile range) 37, 24–40 vs. 71, 56–125 HU, P = 0.01] than those without. On immunohistochemistry and confocal fluorescence microscopy, CD68 and PBR co-localized with 3H-PK11195 uptake at autoradiography. There was a significant correlation between 11C-PK11195 TBR and autoradiographic percentage-specific binding (r = 0.77, P = 0.025). Both TBR and CT plaque attenuation had high negative predictive values (91 and 92%, respectively) for detecting symptomatic patients. However, the best positive predictive value (100%) was achieved when TBR and CT attenuation were combined. Conclusion Imaging intraplaque inflammation in vivo with 11C-PK11195 PET/CTA is feasible and can distinguish between recently symptomatic and asymptomatic plaques. Patients with a recent ischaemic event had ipsilateral plaques with lower CT attenuation and increased 11C-PK11195 uptake. (literal)

Prodotto di

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Attività fisica e risposta cardiocircolatoria nella patologia dismetabolica e cardiovascolare (ME.P01.002.006) (Modulo)

Autore CNR

• ORNELLA RIMOLDI (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Imaging intraplaque inflammation in carotid atherosclerosis with 11C-PK11195 positron emission tomography/computed tomography" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Attività fisica e risposta cardiocircolatoria nella patologia dismetabolica e cardiovascolare (ME.P01.002.006) (Modulo)

Autore CNR di

• ORNELLA RIMOLDI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European heart journal (Rivista)

Insieme di parole chiave di

• Parole chiave di "Imaging intraplaque inflammation in carotid atherosclerosis with 11C-PK11195 positron emission tomography/computed tomography" (Insieme di parole chiave)