From cancer metabolism to new biomarkers and drug targets. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• From cancer metabolism to new biomarkers and drug targets. (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Alternative label

• Chiaradonna F. 1, Moresco R.M. 2,3,4, Airoldi C. 1, Gaglio D. 1, Palorini R. 1, Nicotra F. 1 , Messa C. 2,4,5, Alberghina L. 1 (2012)
  From cancer metabolism to new biomarkers and drug targets.
  in Biotechnology advances
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Chiaradonna F. 1, Moresco R.M. 2,3,4, Airoldi C. 1, Gaglio D. 1, Palorini R. 1, Nicotra F. 1 , Messa C. 2,4,5, Alberghina L. 1 (literal)

Pagina inizio

• 30 (literal)

Pagina fine

• 51 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 30 (literal)

Rivista

• Biotechnology advances (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• Pubblicato on-line: 23 Luglio 2011 Corresponding authors: F. Chiaradonna (ferdinando.chiaradonna@unimib.it) - L. Alberghina (lilia.alberghina@unimib.it) IF 2010: 7.600 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milano. 2.Tecnomed Foundation University of Milano-Bicocca, Monza. 3. San Raffaele Institute, Milano. 4. IBFM-CNR, Segrate (MI). 5. Tecnomed Foundation University of Milano-Bicocca and San Gerardo Hospital, Monza. (literal)

Titolo

• From cancer metabolism to new biomarkers and drug targets. (literal)

Abstract

• Great interest is presently given to the analysis of metabolic changes that take place specifically in cancer cells. In this review we summarize the alterations in glycolysis, glutamine utilization, fatty acid synthesis and mitochondrial dysfunction that have been reported to occur in cancer cells and in human tumors. We then propose considering cancer as a system-level disease and argue how two hallmarks of cancer, enhanced cell proliferation and evasion from apoptosis, may be evaluated as system-level properties, and how this perspective is going to modify drug discovery. Given the relevance of the analysis of metabolism both for studies on the molecular basis of cancer cell phenotype and for clinical applications, the more relevant technologies for this purpose, from metabolome and metabolic flux analysis in cells by Nuclear Magnetic Resonance and Mass Spectrometry technologies to positron emission tomography on patients, are analyzed. The perspectives offered by specific changes in metabolism for a new drug discovery strategy for cancer are discussed and a survey of the industrial activity already going on in the field is reported. (literal)

Prodotto di

• Imaging molecolare in oncologia (ME.P06.006.003) (Modulo)
• Imaging pre-clinico (ME.P06.006.002) (Modulo)
• Institute of molecular bioimaging and physiology (IBFM) (Istituto)

Autore CNR

• ROSA MARIA MORESCO (Persona)
• MARIA CRISTINA MESSA (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "From cancer metabolism to new biomarkers and drug targets." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIA CRISTINA MESSA (Unità di personale esterno)
• ROSA MARIA MORESCO (Persona)

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Imaging pre-clinico (ME.P06.006.002) (Modulo)
• Imaging molecolare in oncologia (ME.P06.006.003) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biotechnology advances (Rivista)

Insieme di parole chiave di

• Keywords of "From cancer metabolism to new biomarkers and drug targets." (Insieme di parole chiave)