http://www.cnr.it/ontology/cnr/individuo/prodotto/ID10523

Lung Regional Metabolic Activity and Gas Volume Changes Induced by Tidal Ventilation in Patients with Acute Lung Injury. (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Lung Regional Metabolic Activity and Gas Volume Changes Induced by Tidal Ventilation in Patients with Acute Lung Injury. (Articolo in rivista) (literal)

Anno

2011-01-01T00:00:00+01:00 (literal)

Alternative label

Bellani G. 1,2, Guerra L. 3,4, Musch G. 5, Zanella A. 1,2, Patroniti N. 1,2, Mauri T. 1,2, Messa C. 3,4,6, Pesenti A. 1,2 (2011)
Lung Regional Metabolic Activity and Gas Volume Changes Induced by Tidal Ventilation in Patients with Acute Lung Injury.
in American journal of respiratory and critical care medicine
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Bellani G. 1,2, Guerra L. 3,4, Musch G. 5, Zanella A. 1,2, Patroniti N. 1,2, Mauri T. 1,2, Messa C. 3,4,6, Pesenti A. 1,2 (literal)

Pagina inizio

1193 (literal)

Pagina fine

1199 (literal)

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183 (literal)

Rivista

American journal of respiratory and critical care medicine (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

Pubblicato on-line: 21 gennaio 2011 Corresponding author: A. Pesenti (antonio.pesenti@unimib.it) IF 2010: 10.191 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1. Department of Experimental Medicine, University of Milan-Bicocca, Monza. 2. Department of Perioperative Medicine and Intensive Care, San Gerardo Hospital, Monza. 3. Nuclear Medicine Unit, San Gerardo Hospital, Monza. 4. Centro Bioimmagini Molecolari, University of Milan-Bicocca, Monza. 5. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA (USA). 6. Institute of Molecular Bioimaging and Physiology (IBFM), National Research Council (CNR), Milano. (literal)

Titolo

Lung Regional Metabolic Activity and Gas Volume Changes Induced by Tidal Ventilation in Patients with Acute Lung Injury. (literal)

Abstract

RATIONALE: During acute lung injury, mechanical ventilation can aggravate inflammation by promoting alveolar distension and cyclic recruitment-derecruitment. As an estimate of the intensity of inflammation, metabolic activity can be measured by positron emission tomography imaging of [(18)F]fluoro-2-deoxy-D-glucose. OBJECTIVE: To assess the relationship between gas volume changes induced by tidal ventilation and pulmonary metabolic activity in patients with acute lung injury. METHODS: In thirteen mechanically ventilated patients with acute lung injury and relatively high PEEP, we performed a positron emission tomography scan of the chest and three computed tomography scans: at mean airway pressure, end-expiration and end-inspiration. Metabolic activity was measured from the [(18)F]fluoro-2-deoxy-D-glucose uptake rate. The computed tomography scans were used to classify lung regions as derecruited throughout the respiratory cycle, undergoing recruitment-derecruitment, and normally aerated. MEASUREMENTS AND MAIN RESULTS: Metabolic activity of normally aerated lung was positively correlated both with plateau pressure, showing a pronounced increase above 26-27 cmH2O, and with regional tidal volume normalized by end-expiratory lung gas volume. This relationship did not appear to be caused by a higher underlying parenchymal metabolic activity in patients with higher plateau pressure. Regions undergoing cyclic recruitment-derecruitment did not have higher metabolic activity than those collapsed throughout the respiratory cycle. CONCLUSIONS: In patients with acute lung injury managed with relatively high end-expiratory pressure, metabolic activity of aerated regions was associated with both plateau pressure and regional tidal volume normalized by end-expiratory lung gas volume, while no association was found between cyclic recruitment-derecruitment and increased metabolic activity. (literal)

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