Changes in plasma levels of ghrelin, leptin and other hormonal and metabolic parameters following standardized breakfast, lunch and physical exercise before and after a multidisciplinary weight-reduction intervention in obese adolescents. (Articolo in rivista)

Type
Label
  • Changes in plasma levels of ghrelin, leptin and other hormonal and metabolic parameters following standardized breakfast, lunch and physical exercise before and after a multidisciplinary weight-reduction intervention in obese adolescents. (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Alternative label
  • Rigamonti A.E. 1, Agosti F. 2, De Col A. 2, Marazzi N. 2, Lafortuna C.L. 3, Cella S.G. 1, Muller E.E. 1, Sartorio A. 2 (2010)
    Changes in plasma levels of ghrelin, leptin and other hormonal and metabolic parameters following standardized breakfast, lunch and physical exercise before and after a multidisciplinary weight-reduction intervention in obese adolescents.
    in Journal of endocrinological investigation (Testo stamp.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Rigamonti A.E. 1, Agosti F. 2, De Col A. 2, Marazzi N. 2, Lafortuna C.L. 3, Cella S.G. 1, Muller E.E. 1, Sartorio A. 2 (literal)
Pagina inizio
  • 633 (literal)
Pagina fine
  • 639 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 33 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • Pubblicato on-line: 25 Marzo 2010. Corresponding author: A. Sartorio (sartorio@auxologico.it) IF 2010: 1.476 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. Dipartimento di Farmacologia Medica, Università di Milano, Milano. 2. Istituto Auxologico Italiano, IRCCS, Laboratorio Sperimentale Ricerche Auxo-Endocrinologiche (LSRE), Milano and Verbania. 3. Istituto di Bioimmagini e Fisiologia Molecolare del Consoglio Nazionale delle Ricerche, Segrate (MI). (literal)
Titolo
  • Changes in plasma levels of ghrelin, leptin and other hormonal and metabolic parameters following standardized breakfast, lunch and physical exercise before and after a multidisciplinary weight-reduction intervention in obese adolescents. (literal)
Abstract
  • To investigate in severely obese adolescents the effects of a 3-week multidisciplinary weight-reduction intervention involving moderate energy restriction, individualised physical activity and behavior therapy on the response of somehormonal and metabolic parameters to meals and exercise. DESIGN: Clinical longitudinal study on in-patients in a specialised institution. SUBJECTS: A total of 20 obese adolescents (10 boys and 10 girls) aged 12-17 yr [body mass index (BMI): 37.7±6.1 kg/m2; fat mass (FM): 44.8±13.2 kg]. MEASUREMENTS: The changes in plasma concentration of leptin, ghrelin, growth hormone (GH), insulin-like growth factor 1 (IGF-1), insulin, glucose and non esterified fatty acids (NEFA) in response to standardised meals and exercise bouts were measured before and after the weight-reduction intervention. At the same times, body composition was assessed by bioelectrical impedance as well as appetite sensations using a visual analog scale. RESULTS: At the end of the intervention, the adolescents had lost body weight and FM (expressed both in kg and %) (P < 0.05), without any significant fat-free mass (FFM) loss (in % terms). In response to both meals and exercise, after the 3-week intervention, plasma leptin concentration decreased significantly (P < 0.05), whereas the other hormones (insulin, ghrelin, GH and IGF-1) and metabolic parameters (glucose and NEFA) did not change. Interestingly, appetite was not affected by the intervention. CONCLUSION: This 3-week multidisciplinary intervention in obese adolescents induced a significant body weight loss with beneficial changes in body composition. However, despite there being no change in metabolic parameters and ghrelin in response to meals and exercise after the intervention, plasma concentrations of leptin were decreased. The failure of ghrelin levels to increase by this approach might explain the good control of appetite observed at the end of the study. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it