Cooperative N-methyl-D-aspartate (NMDA) receptor antagonism and mu-opioid receptor agonism mediate the methadone inhibition of the spinal neuron pain-related hyperactivity in a rat model of neuropathic pain. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Cooperative N-methyl-D-aspartate (NMDA) receptor antagonism and mu-opioid receptor agonism mediate the methadone inhibition of the spinal neuron pain-related hyperactivity in a rat model of neuropathic pain. (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.phrs.2009.04.002 (literal)

Alternative label

• Sotgiu M.L. 1, Valente M. 1, Storchi R. 1,2, Caramenti G. 3, Biella G.E. 1 (2009)
  Cooperative N-methyl-D-aspartate (NMDA) receptor antagonism and mu-opioid receptor agonism mediate the methadone inhibition of the spinal neuron pain-related hyperactivity in a rat model of neuropathic pain.
  in Pharmacological research (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Sotgiu M.L. 1, Valente M. 1, Storchi R. 1,2, Caramenti G. 3, Biella G.E. 1 (literal)

Pagina inizio

• 284 (literal)

Pagina fine

• 290 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 60 (literal)

Rivista

• Pharmacological research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• Corresponding author: ML Sotgiu (marialuisa.sotgiu@ibfm.cnr.it). IF 2009: 3.929 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Institute of Molecular Bioimaging and Physiology (IBFM), National Research Council (CNR), Segrate (MI) 2. Dept. of Biomedical Sciences, School of Neuroscience, University of Modena, Modena 3. Institute of Biomedical Technology (ITB), National Research Council (CNR), Segrate (MI) (literal)

Titolo

• Cooperative N-methyl-D-aspartate (NMDA) receptor antagonism and mu-opioid receptor agonism mediate the methadone inhibition of the spinal neuron pain-related hyperactivity in a rat model of neuropathic pain. (literal)

Abstract

• Methadone (Racemic methadone) exerts its antinociceptive effect by activation of mu-opioid receptors and/or blockade of NMDA receptors. The aim of this study is to determine whether the methadone analgesic effect on neuropathic pain is achieved only by the agonism of the mu-opioid receptors or cooperatively with the antagonism of the NMDA receptors. To this purpose, in rats with neuropathic pain model of chronic constriction of one sciatic nerve (CCI rats), we administered methadone before or after opioid receptor blockade with naloxone and checked its effects on the spinal Wide Dynamic Range (WDR) neuron dynamics in three experimental conditions: on the spontaneous and noxious evoked neuronal activities in control rats (sham operated and naïve); on iontophoretic NMDA induced neuronal hyperactivity in intact rats; on pain-related spontaneous and noxious evoked hyperactivities in CCI rats. The results, as from the spike-frequency analysis, show that: (i) in control rats, methadone inhibits the noxious evoked neuronal activity and naloxone prevents or reverses about 94% of methadone inhibitory effect; (ii) in intact rats, pretreated with naloxone, methadone reduces the NMDA induced neuronal hyperactivity; (iii) in CCI rats, methadone inhibits the neuronal spontaneous and noxious evoked hyperactivities, and naloxone prevents or reverses about 60% of methadone inhibitory effect. These findings allow to conclude that methadone inhibition of the noxious evoked activity in normal rats is achieved predominantly through the agonism of the mu-opioid receptors, while the inhibition of the pain-related hyperactivity in rats with signs of neuropathic pain (CCI rats), involves also the NMDA receptors antagonism. (literal)

Prodotto di

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Neurofisiologia e fisiopatologia di network sensoriali nel dolore cronico (ME.P02.003.002) (Modulo)

Autore CNR

• RICCARDO STORCHI (Unità di personale esterno)
• MARIA LUISA SOTGIU (Persona)
• GABRIELE BIELLA (Persona)
• GIAN CARLO CARAMENTI (Unità di personale interno)
• MAURIZIO VALENTE (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "Cooperative N-methyl-D-aspartate (NMDA) receptor antagonism and mu-opioid receptor agonism mediate the methadone inhibition of the spinal neuron pain-related hyperactivity in a rat model of neuropathic pain." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• GIAN CARLO CARAMENTI (Unità di personale interno)
• GABRIELE BIELLA (Persona)
• MAURIZIO VALENTE (Unità di personale esterno)
• MARIA LUISA SOTGIU (Persona)
• RICCARDO STORCHI (Unità di personale esterno)

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Neurofisiologia e fisiopatologia di network sensoriali nel dolore cronico (ME.P02.003.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Pharmacological research (Rivista)

Insieme di parole chiave di

• Keywords of "Cooperative N-methyl-D-aspartate (NMDA) receptor antagonism and mu-opioid receptor agonism mediate the methadone inhibition of the spinal neuron pain-related hyperactivity in a rat model of neuropathic pain." (Insieme di parole chiave)