Multifocal, persistent cardiac uptake of [18-F]-Fluoro-Deoxy-Glucose detected by positron emission tomography in patients with acute myocardial infarction. (Articolo in rivista)

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  • Multifocal, persistent cardiac uptake of [18-F]-Fluoro-Deoxy-Glucose detected by positron emission tomography in patients with acute myocardial infarction. (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Godino C. 1, Messa C. 2,3, Gianolli L. 4, Landoni C. 2,4, Margonato A. 1, Cera M. 1, Stefano C. 1, Cianflone D. 1, Fazio F. 2,3,4, Maseri A. 1 (2008)
    Multifocal, persistent cardiac uptake of [18-F]-Fluoro-Deoxy-Glucose detected by positron emission tomography in patients with acute myocardial infarction.
    in Circulation journal
    (literal)
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  • Godino C. 1, Messa C. 2,3, Gianolli L. 4, Landoni C. 2,4, Margonato A. 1, Cera M. 1, Stefano C. 1, Cianflone D. 1, Fazio F. 2,3,4, Maseri A. 1 (literal)
Pagina inizio
  • 1821 (literal)
Pagina fine
  • 1828 (literal)
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  • 72 (literal)
Rivista
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  • Pubblicato on-line: 29 Settembre 2008. Corresponding author: C. Messa (c.messa@hsgerardo.org) I.F.: 2.387 (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • 1. Cardio-Thoracic and Vascular Department, San Raffaele Scientific Institute, Milano 2. University of Milano-Bicocca, Milano 3. CNR-Institute of Molecular BioImaging and Physiological, Milano 4. Nuclear Medicine Department, Scientific Institute San Raffaele, Milano (literal)
Titolo
  • Multifocal, persistent cardiac uptake of [18-F]-Fluoro-Deoxy-Glucose detected by positron emission tomography in patients with acute myocardial infarction. (literal)
Abstract
  • Background Inflammation appears to be important in the pathogenesis of acute myocardial infarction (AMI). Methods and Results Cardiac [18-F]-fluoro-deoxy-glucose (FDG) uptake by positron emission tomography/computed tomography (PET/CT)-scan was investigated in 12 fasting patients with first AMI (FAMI) single-vessel disease after successful primary percutaneous coronary intervention and at 9 weeks follow-up, and in 12 controls. The average FDG uptake (aFDGu) of the 28 left ventricular (LV) wall segments defined on the PET/CT images of the 12 FAMI patients was 1.28±0.57-fold higher than the activity present in the LV cavity. By contrast, the aFDGu of the 12 controls was 0.70±22 (p<0.001). The segmental aFDGu in the FAMI was multifocal in both the culprit and non-culprit segments; it was less than LV cavity activity in 38%, 1-2-fold greater in 51.8% and more than 2-fold greater in 10.2%. At follow-up, aFDGu was significantly increased in both culprit and non-culprit segments (1.69±1.15, p<0.001). Statistically significant differences between FAMI and controls patients were only found for interleukin-6 plasma levels on admission (11.3±7.7 pg/ml vs 2.2±1.3 pg/ml; p<0.004). Conclusion Multifocal, non-infarct related, cardiac-FDG-uptake occurred immediately after AMI and persisted at follow-up. The cause of these striking and consistent findings is still speculative (literal)
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