Binding of paroxetine to the serotonin transporter in membranes from different dells, subcellular fractions and species (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Binding of paroxetine to the serotonin transporter in membranes from different dells, subcellular fractions and species (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Alternative label

• Cupello A. 1,2, Albano C. 3, Gatta E. 2, Scarrone S. 1, Villa E. 1, Zona G. 4 (2009)
  Binding of paroxetine to the serotonin transporter in membranes from different dells, subcellular fractions and species
  in Neurochemical research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Cupello A. 1,2, Albano C. 3, Gatta E. 2, Scarrone S. 1, Villa E. 1, Zona G. 4 (literal)

Pagina inizio

• 255 (literal)

Pagina fine

• 259 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 34 (literal)

Rivista

• Neurochemical research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• Pubblicato on-line: 18 Giugno 2008 Corresponding author: A. Cupello (aroldo.cupello@unige.it) IF 2008: 2.722 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. IBFM, CNR, Sezione di Genova, Genova 2. c/o Dipartimento di Fisica, Università di Genova, Genova 3. Neurologia, DINOG, Università di Genova, Genova 4. Neurochirurgia, DINOG, Università di Genova, Genova (literal)

Titolo

• Binding of paroxetine to the serotonin transporter in membranes from different dells, subcellular fractions and species (literal)

Abstract

• The binding of [(3)H]-paroxetine to membrane serotonin transporter (SERT) has been studied in membranes from different sources and subcellular fractions. From rat were membranes from venous blood platelets, brain total cortex, brain microsomes, brain crude and purified synaptosomes. Membranes were obtained from venous blood platelets from human volunteers and from brain cortex tissue from neurosurgery (cerebral lobectomies following craniocerebral injuries). The main finding was that the K (D) of paroxetine binding to the SERT was the same for platelet and nerve ending (synaptosomal) membranes. That parameter was significantly lower in membranes from brain microsomes and cortex total tissue. No species related difference was found, where comparison was possible, between human and rat tissue. The equality of K (D) of paroxetine binding to blood platelet membranes and to membranes from nerve endings appears to encourage the use of such membranes as a model for brain SERT. Binding at two different temperatures for several of the fractions suggests that paroxetine-SERT interaction is entropy-driven. (literal)

Prodotto di

• Neurofisiopatologia e clinica (ME.P02.003.001) (Modulo)
• Institute of molecular bioimaging and physiology (IBFM) (Istituto)

Autore CNR

• SIMONA SCARRONE (Persona)
• AROLDO CUPELLO (Unità di personale interno)
• CLAUDIO ALBANO (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "Binding of paroxetine to the serotonin transporter in membranes from different dells, subcellular fractions and species" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Neurofisiopatologia e clinica (ME.P02.003.001) (Modulo)

Autore CNR di

• AROLDO CUPELLO (Unità di personale interno)
• CLAUDIO ALBANO (Unità di personale esterno)
• SIMONA SCARRONE (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neurochemical research (Rivista)

Insieme di parole chiave di

• Keywords of "Binding of paroxetine to the serotonin transporter in membranes from different dells, subcellular fractions and species" (Insieme di parole chiave)