[(11)C]Choline uptake with PET/CT for the initial diagnosis of prostate cancer: relation to PSA levels, tumour stage and anti-androgenic therapy. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• [(11)C]Choline uptake with PET/CT for the initial diagnosis of prostate cancer: relation to PSA levels, tumour stage and anti-androgenic therapy. (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Alternative label

• Giovacchini G. 1, Picchio M. 2, Coradeschi E. 1, Scattoni V. 3, Bettinardi V. 2, Cozzarini C. 4, Freschi M. 5, Fazio F. 1,2,4,6, Messa C. 1,4,6 (2008)
  [(11)C]Choline uptake with PET/CT for the initial diagnosis of prostate cancer: relation to PSA levels, tumour stage and anti-androgenic therapy.
  in European journal of nuclear medicine and molecular imaging (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Giovacchini G. 1, Picchio M. 2, Coradeschi E. 1, Scattoni V. 3, Bettinardi V. 2, Cozzarini C. 4, Freschi M. 5, Fazio F. 1,2,4,6, Messa C. 1,4,6 (literal)

Pagina inizio

• 1065 (literal)

Pagina fine

• 1073 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 35 (literal)

Rivista

• European journal of nuclear medicine and molecular imaging (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• Corresponding author: C. Messa (c.messa@hsgerardo.org) I.F.: 4.532 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Center for Molecular Bioimaging, University of Milano-Bicocca, Milan, Italy 2. Department of Nuclear Medicine, Scientific Institute San Raffaele, Milan, Italy 3. Department of Urology, Scientific Institute San Raffaele, Milan, Italy 4. Department of Radiation Oncology, Scientific Institute San Raffaele, Milan, Italy 5. Department of Pathology, Scientific Institute San Raffaele, Milan, Italy 6. Institute for Bioimaging and Molecular Physiology, National Research Council, Milan, Italy 7. Department Nuclear Medicine, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy (literal)

Titolo

• [(11)C]Choline uptake with PET/CT for the initial diagnosis of prostate cancer: relation to PSA levels, tumour stage and anti-androgenic therapy. (literal)

Abstract

• Purpose The accuracy of positron emission tomography (PET)/CT with [11C]choline for the detection of prostate cancer is not well established. We assessed the dependence of [11C]choline maximum standardized uptake values (SUVmax) in the prostate gland on cell malignancy, prostate-specific antigen (PSA) levels, Gleason score, tumour stage and anti-androgenic hormonal therapy. Methods In this prospective study, PET/CT with [11C]choline was performed in 19 prostate cancer patients who subsequently underwent prostatectomy with histologic sextant analysis (group A) and in six prostate cancer patients before and after anti-androgenic hormonal therapy (bicalutamide 150 mg/day; median treatment of 4 months; group B). Results In group A, based on a sextant analysis with a [11C]choline SUVmax cutoff of 2.5 (as derived from a receiver-operating characteristic analysis), PET/CT showed sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 72, 43, 64, 51 and 60%, respectively. In the patient-by-patient analysis, no significant correlation was detected between SUVmax and PSA levels, Gleason score or pathological stage. On the contrary, a significant (P < 0.05) negative correlation was detected between SUVmax and anti-androgenic therapy both in univariate (r 2 = 0.24) and multivariate (r 2 = 0.48) analyses. Prostate [11C]choline uptake after bicalutamide therapy significantly (P < 0.05) decreased compared to baseline (6.4 ± 4.6 and 11.8 ± 5.3, respectively; group B). Conclusion PET/CT with [11C]choline is not suitable for the initial diagnosis and local staging of prostate cancer. PET/CT with [11C]choline could be used to monitor the response to anti-androgenic therapy. (literal)

Prodotto di

• Imaging molecolare e stadiazione (ME.P03.002.001) (Modulo)
• Institute of molecular bioimaging and physiology (IBFM) (Istituto)

Autore CNR

• MARIA PICCHIO (Unità di personale esterno)
• GIAMPIERO GIOVACCHINI (Persona)
• ELISA CORADESCHI (Persona)
• FERRUCCIO FAZIO (Unità di personale esterno)
• VALENTINO BETTINARDI (Persona)
• MARIA CRISTINA MESSA (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "[(11)C]Choline uptake with PET/CT for the initial diagnosis of prostate cancer: relation to PSA levels, tumour stage and anti-androgenic therapy." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIA CRISTINA MESSA (Unità di personale esterno)
• GIAMPIERO GIOVACCHINI (Persona)
• VALENTINO BETTINARDI (Persona)
• MARIA PICCHIO (Unità di personale esterno)
• ELISA CORADESCHI (Persona)
• FERRUCCIO FAZIO (Unità di personale esterno)

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Imaging molecolare e stadiazione (ME.P03.002.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European journal of nuclear medicine and molecular imaging (Rivista)

Insieme di parole chiave di

• Keywords of "[(11)C]Choline uptake with PET/CT for the initial diagnosis of prostate cancer: relation to PSA levels, tumour stage and anti-androgenic therapy." (Insieme di parole chiave)