Protective effects of some creatine derivatives in brain tissue anoxia (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Protective effects of some creatine derivatives in brain tissue anoxia (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Alternative label

• Perasso L. 1, Lunardi G.L. 2, Risso F. 1, Pohvozcheva A.V. 3, Leko M.V. 3, Gandolfo C. 1,4, Florio T. 2, Cupello A. 4, Burov S.V. 3, Balestrino M. 1 (2008)
  Protective effects of some creatine derivatives in brain tissue anoxia
  in Neurochemical research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Perasso L. 1, Lunardi G.L. 2, Risso F. 1, Pohvozcheva A.V. 3, Leko M.V. 3, Gandolfo C. 1,4, Florio T. 2, Cupello A. 4, Burov S.V. 3, Balestrino M. 1 (literal)

Pagina inizio

• 765 (literal)

Pagina fine

• 775 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 33 (literal)

Rivista

• Neurochemical research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• Corresponding author: M. Balestrino (mbalestrino@neurologia.unige.it) I.F.: 2.260 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Department of Neuroscience, Ophthalmology and Genetics, University of Genova, Genova 2. Section of Pharmacology, Department of Oncology, Biology and Genetics, University of Genova, Genova 3. Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg, Russia 4. Institute of Bioimaging and Molecular Physiology, Section of Genova, National Research Council (CNR), Genova (literal)

Titolo

• Protective effects of some creatine derivatives in brain tissue anoxia (literal)

Abstract

• Some derivatives more lipophylic than creatine, thus theoretically being capable to better cross the blood–brain barrier, were studied for their protective effect in mouse hippocampal slices. We found that N-amidino-piperidine is harmful to brain tissue, and that phosphocreatine is ineffective. Creatine, creatine–Mg-complex (acetate) and phosphocreatine–Mg-complex (acetate) increased the latency to population spike disappearance during anoxia. Creatine and creatine–Mg-complex (acetate) also increased the latency of anoxic depolarization, while the delay induced by phosphocreatine–Mg-complex (acetate) was of borderline significance (P = 0.056). Phosphocreatine–Mg-complex (acetate) significantly reduced neuronal hyperexcitability during anoxia, an effect that no other compound (including creatine itself) showed. For all parameters except reduced hyperexcitability the effects statistically correlated with tissue levels of creatine or phosphocreatine. Summing up, exogenous phosphocreatine and N-amidino piperidine are not useful for brain protection, while chelates of both creatine and phosphocreatine do replicate some of the known protective effects of creatine. In addition, phosphocreatine–Mg-complex (acetate) also reduced neuronal hyperexcitability during anoxia. (literal)

Prodotto di

• Neurofisiopatologia e clinica (ME.P02.003.001) (Modulo)
• Institute of molecular bioimaging and physiology (IBFM) (Istituto)

Autore CNR

• CARLO GANDOLFO (Persona)
• AROLDO CUPELLO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Protective effects of some creatine derivatives in brain tissue anoxia" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Neurofisiopatologia e clinica (ME.P02.003.001) (Modulo)

Autore CNR di

• AROLDO CUPELLO (Unità di personale interno)
• CARLO GANDOLFO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neurochemical research (Rivista)

Insieme di parole chiave di

• Keywords of "Protective effects of some creatine derivatives in brain tissue anoxia" (Insieme di parole chiave)