GH responses to two consecutive bouts of neuromuscular electrical stimulation in healthy adults. (Articolo in rivista)

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  • GH responses to two consecutive bouts of neuromuscular electrical stimulation in healthy adults. (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Sartorio A. 1,2, Jubeau M. 3, Agosti F. 2, De Col A. 2, Marazzi N. 2, Lafortuna C.L. 4, Maffiuletti N.A.3,5 (2008)
    GH responses to two consecutive bouts of neuromuscular electrical stimulation in healthy adults.
    in European journal of endocrinology
    (literal)
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  • Sartorio A. 1,2, Jubeau M. 3, Agosti F. 2, De Col A. 2, Marazzi N. 2, Lafortuna C.L. 4, Maffiuletti N.A.3,5 (literal)
Pagina inizio
  • 311 (literal)
Pagina fine
  • 316 (literal)
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  • 158 (literal)
Rivista
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  • Correspondig author: A. Sartorio (sartorio@auxologico.it) I.F.: 3.791 (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • 1. Istituto Auxologico Italiano, IRCCS, Divisione Malattie Metaboliche 3, Verbania. 2. Laboratorio Sperimentale di Ricerche Auxo-Endocrinologiche, Verbania 3. Laboratory INSERM U887 Motricity-Plasticity, Faculty of Sports Sciences, University of Burgundy, Dijon (France) 4. Institute of Bioimaging and Molecular Physiology, CNR, Segrate (MI) 5. Neuromuscular Research Laboratory, Schulthess Clinic, Zurich (Switzerland) (literal)
Titolo
  • GH responses to two consecutive bouts of neuromuscular electrical stimulation in healthy adults. (literal)
Abstract
  • Background: It is well established that repeated GHRH administration or repeated voluntary exercise bouts are associated with a complete blunting of GH responsiveness when the administration of the second stimulus follows the first one after a 2-h interval. Aim: To evaluate GH responses to neuromuscular electrical stimulation (NMES) in healthy adults. Methods: Six volunteers (mean age+/-s.d. 31.7+/-5.5 years) were studied before and after two consecutive bouts of NMES exercise (a series of 20 contractions at the maximum of individual tolerance, frequency: 75 Hz, pulse duration: 400 mus, on-off ratio: 6.25-20 s) administered at a 2-h interval. Results Baseline GH levels (mean: 0.3+/-0.2 ng/ml) significantly increased after the first NMES (peak: 4.2+/-3.7 ng/ml), with a complete normalization after 120 min (0.3+/-0.3 ng/ml). The administration of the second bout of NMES of comparable characteristics also resulted in a significant GH increase (peak: 5.2+/-3.2 ng/ml), which was comparable with that observed after the previous one. GH net incremental area under the curve after the first and second bouts of NMES were not significantly different (155.1+/-148.5 and 176.9+/-123.3 ng/ml per h, P=0.785). Conclusions: Unlike repeated pharmacological stimuli and voluntary exercise bouts, subsequent sessions of NMES administered at a 2-h interval appear to circumvent feedback mechanisms and to re-induce the GH responses, thus indicating a possible different underlying mechanism elicited by different GH-releasing stimuli. (literal)
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