Synthesis and carbon-11 labeling of (R)- and (S)-thionisoxetine, norepinephrine reuptake inhibitors, potential radioligands for positron emission tomography. (Articolo in rivista)

Type
Label
  • Synthesis and carbon-11 labeling of (R)- and (S)-thionisoxetine, norepinephrine reuptake inhibitors, potential radioligands for positron emission tomography. (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.apradiso.2007.06.004 (literal)
Alternative label
  • Filannino M.A. 1, Matarrese M. 1, Turolla E.A. 1, Masiello V. 1, Moresco R.M. 1, Todde S. 1, Verza E. 1, Magni F. 2, Cattaneo A. 1, Bachi A. 1, Kienle M.G. 2, Fazio F. 1 (2007)
    Synthesis and carbon-11 labeling of (R)- and (S)-thionisoxetine, norepinephrine reuptake inhibitors, potential radioligands for positron emission tomography.
    in Applied radiation and isotopes
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Filannino M.A. 1, Matarrese M. 1, Turolla E.A. 1, Masiello V. 1, Moresco R.M. 1, Todde S. 1, Verza E. 1, Magni F. 2, Cattaneo A. 1, Bachi A. 1, Kienle M.G. 2, Fazio F. 1 (literal)
Pagina inizio
  • 1232 (literal)
Pagina fine
  • 1239 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 65 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. Institute of Molecular Bioimaging and Physiology, CNR, University of Milano-Bicocca, San Raffaele Scientific Institute, Milano 2. University of Milano-Bicocca, DIMESAB, Monza (MI) (literal)
Titolo
  • Synthesis and carbon-11 labeling of (R)- and (S)-thionisoxetine, norepinephrine reuptake inhibitors, potential radioligands for positron emission tomography. (literal)
Abstract
  • Standards and des-methyl precursors of (R)- and (S)-thionisoxetine, potent and selective norepinephrine reuptake inhibitors, were synthesized and radiolabeled with carbon-11. Both enantiomers of the N-methyl-3-(2-thiomethylphenoxy)-3-phenylpropanamine and the 3-(2-thiomethylphenoxy)-3-phenylpropylamine were obtained via multi-step syntheses, while the radiosyntheses were carried out using [(11)C]CH(3)I. The radiochemical yields were 26%, decay corrected and the specific radioactivity ranging from 2 to 3Ci/mumol. The HPLC analyses were performed using a chiral column: during the radiolabeling, no racemization occurred and the isomers were synthesized with high enantiomeric purity (literal)
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