Sharp beveled tip hollow microneedle arrays fabricated by LIGA and 3D soft lithography with polyvinyl alcohol (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Sharp beveled tip hollow microneedle arrays fabricated by LIGA and 3D soft lithography with polyvinyl alcohol (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Alternative label

• Perennes, F; Marmiroli, B; Matteucci, M; Tormen, M; Vaccari, L; Di Fabrizio, E (2006)
  Sharp beveled tip hollow microneedle arrays fabricated by LIGA and 3D soft lithography with polyvinyl alcohol
  in Journal of micromechanics and microengineering (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Perennes, F; Marmiroli, B; Matteucci, M; Tormen, M; Vaccari, L; Di Fabrizio, E (literal)

Pagina inizio

• 473 (literal)

Pagina fine

• 479 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 16 (literal)

Rivista

• Journal of micromechanics and microengineering (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Sincrotrone Trieste, I-34012 Trieste, Italy; INFM, TASC, I-34012 Trieste, Italy; Univ Magna Graecia, BIONEM Lab, I-88100 Catanzaro, Italy (literal)

Titolo

• Sharp beveled tip hollow microneedle arrays fabricated by LIGA and 3D soft lithography with polyvinyl alcohol (literal)

Abstract

• This paper describes a fabrication process of hollow microneedle arrays with a sharp beveled tip for transdermal drug delivery. A master is fabricated through a double deep x-ray lithography process. First, a polymethylmethacrylate (PMMA) sheet is exposed to produce single PMMA parts with a sawtooth profile. The tip angle of each tooth determines the final tip angle of the rnicroneedles. The PMMA parts are assembled and glued on a conductive substrate and then exposed through a second x-ray mask containing an array of hollow triangles as absorbing structures. A metal layer is then electrodeposited around the needles in order to form the future base of the array. A polyvinyl alcohol (PVA) solution is cast on top of the master to form a negative mold of the microneedle array after a low temperature curing and peel-off steps. A liquid PMMA solution is cast on top of the PVA negative mold and after the full PMMA polymerization the PVA is dissolved in water. This fabrication method can be performed in a non-clean room environment and requires little instrumentation. It is therefore compatible with a low-cost mass-fabrication scheme. (literal)

Prodotto di

• Nanofabbricazione (MD.P06.017.001) (Modulo)

Autore CNR

• ENZO MARIO DI FABRIZIO (Unità di personale esterno)
• MASSIMO TORMEN (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Sharp beveled tip hollow microneedle arrays fabricated by LIGA and 3D soft lithography with polyvinyl alcohol" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MASSIMO TORMEN (Unità di personale interno)
• ENZO MARIO DI FABRIZIO (Unità di personale esterno)

Prodotto

• Nanofabbricazione (MD.P06.017.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of micromechanics and microengineering (Rivista)

Insieme di parole chiave di

• Parole chiave di "Sharp beveled tip hollow microneedle arrays fabricated by LIGA and 3D soft lithography with polyvinyl alcohol" (Insieme di parole chiave)