Cytochrome c oxidase expression in chronic and intermittent hypoxia rat gastrocnemius muscle quantitated by CE. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Cytochrome c oxidase expression in chronic and intermittent hypoxia rat gastrocnemius muscle quantitated by CE. (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Alternative label

• Ripamonti M. 1, Viganò A. 2, Moriggi M. 2, Milano G. 3, von Segesser L.K. 3, Samaja M. 4, Gelfi C. 1,2 (2006)
  Cytochrome c oxidase expression in chronic and intermittent hypoxia rat gastrocnemius muscle quantitated by CE.
  in Electrophoresis (Weinh., Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ripamonti M. 1, Viganò A. 2, Moriggi M. 2, Milano G. 3, von Segesser L.K. 3, Samaja M. 4, Gelfi C. 1,2 (literal)

Pagina inizio

• 3897 (literal)

Pagina fine

• 3903 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 27 (literal)

Rivista

• Electrophoresis (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Institute of Molecular Bioimaging and Physiology, CNR Segrate Milano, Milano, Italy 2. Department of Sciences and Biomedical Technologies, University of Milano, Milano, Italy 3. Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland 4. Department of Medicine, Surgery and Dentistry, University of Milano, San Paolo Hospital, Milano, Italy (literal)

Titolo

• Cytochrome c oxidase expression in chronic and intermittent hypoxia rat gastrocnemius muscle quantitated by CE. (literal)

Abstract

• We investigated the effects of hypoxia and intermittent hypoxia in rat muscle by quantitating the expression of genes encoding cytochrome c oxidase (CytOx) subunits I, II and IV, and ribosomal 12S RNA. The quantitative assessment was made by CE in a polymer network, laser being used to facilitate the detection of induced fluorescence. Constant and intermittent hypoxia influence gene expression and ribosomal activity to different degrees. We found constant hypoxia to be accompanied by an increment in the mitochondrial CytOx subunit transcripts II and I and 12S ribosomal subunit, whereas the nuclear subunit (IV) remained unchanged. No changes were observed in intermittent hypoxic rats. Despite the increment in messenger expression, the decrease in enzyme activity was accompanied by a decrease in citrate synthase activity, a marker of mitochondrial function. The increment in CytOx mitochondrial subunits messengers and ribosomal 12S RNA under prolonged chronic hypoxia could be a consequence of reduced protein synthesis that leads to messenger accumulation. (literal)

Prodotto di

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Genomica e proteomica per la ricerca di biomarcatori in malattie neurodegenerative e nei tumori (ME.P05.002.001) (Modulo)

Autore CNR

• CECILIA GELFI (Unità di personale interno)
• MARILENA RIPAMONTI (Persona)

Insieme di parole chiave

• Parole chiave di "Cytochrome c oxidase expression in chronic and intermittent hypoxia rat gastrocnemius muscle quantitated by CE." (Insieme di parole chiave)

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Autore CNR di

• CECILIA GELFI (Unità di personale interno)
• MARILENA RIPAMONTI (Persona)

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Genomica e proteomica per la ricerca di biomarcatori in malattie neurodegenerative e nei tumori (ME.P05.002.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Electrophoresis (Rivista)

Insieme di parole chiave di

• Parole chiave di "Cytochrome c oxidase expression in chronic and intermittent hypoxia rat gastrocnemius muscle quantitated by CE." (Insieme di parole chiave)