Release of hemopoietic and endothelial progenitors after endurance and maximal exercise in runners. (Abstract/Poster in atti di convegno)

Type
Label
  • Release of hemopoietic and endothelial progenitors after endurance and maximal exercise in runners. (Abstract/Poster in atti di convegno) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Alternative label
  • M.R. BONSIGNORE 1; G. MORICI 2; R. RICCIONI 3; V. RITI 3; E. PETRUCCI 3; L. PASQUINI 3; A. BONANNO 4; A. PATERNO' 1; A. HUERTAS 5; L. CHIMENTI 1; M. VECA 2; V. BELLIA 1; P. PALANGE 5; U. TESTA 3 (2007)
    Release of hemopoietic and endothelial progenitors after endurance and maximal exercise in runners.
    in ERS Annual Congress 2007, Stockolm, Sweden, September 15-9, 2007
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • M.R. BONSIGNORE 1; G. MORICI 2; R. RICCIONI 3; V. RITI 3; E. PETRUCCI 3; L. PASQUINI 3; A. BONANNO 4; A. PATERNO' 1; A. HUERTAS 5; L. CHIMENTI 1; M. VECA 2; V. BELLIA 1; P. PALANGE 5; U. TESTA 3 (literal)
Pagina inizio
  • 21S E295 (literal)
Pagina fine
  • 21S (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 30 (suppl 51) (literal)
Rivista
Note
  • Abstract (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Dpt. ofMed,Pneumol,PhysiolandNutrition,University of Palermo,Palermo,Italy; 2Dpt. ofExpMed,UniversityofPalermo,Palermo, Italy; 3Dpt ofMedicalOncology,NatlInstofHealth(ISS),Rome,Italy; 4Inst of BiomedicineandMolecularImmunol,NationalResearchCouncil(CNR), Palermo,Italy; 5Dpt. ofClinicalMedicine,\"LaSapienza\"Univ,Rome,Italy (literal)
Titolo
  • Release of hemopoietic and endothelial progenitors after endurance and maximal exercise in runners. (literal)
Abstract
  • Release ofbonemarrow-derivedprogenitorsdiffersbetweenendurance(Bon- signore etal,JApplPhysiol2002)andpowerathletes(Moricietal,AmJPhysiol 2005). Weinvestigatedhemopoieticandangiogeneticprogenitorreleaseinrunners after the2005PalermoMarathon(n=9,meanage±SD: 44±12 yr,training:88±35 km/wk) andaftermaximalexercise(1500mrunning,n=7,VO2peak:45±6 ml/min/kg). Venousbloodwasobtainedatrestand5-10minpost-exercise,and hemopoietic progenitorswereevaluatedbyflowcytometry(CD34+,CD133+)and clonogeneticassays(BFU-E,CFU-GM,CFU-GEMM).Angiogeneticprogenitors wereassessedbyflowcytometryasVE-cadherin+CD133+,VEGFR2+CD34+ cells orcirculatingangiogeniccells(CAC).Afterthemarathon,totalCD34+ cells wereunchangedandclonogeneticassaysshoweda50-60%decreaseinthe number ofhemopoieticcolonies.After1500mrunning,CD34+cellsdoubledand BFU-E, CFU-GM,CFU-GEMMincreased.VEGFR2+CD34+cellsincreasedby 1.5-fold afterbothmarathonandmaximalexercise.CACreleasewasmoremarked after themarathon(+333±192%) thanaftermaximalexercise(+162±70%), while release ofVE-cadherin+CD133+cellsshowedanoppositebehaviour(+139±83 vs +285±132%). Thesechangeswereassociatedwithreleaseofangiogeneticgrowth factors.Therefore,intrainedrunnersexercisecausedsignificantmobilizationof angiogeneticprogenitorsmodulatedbyexercisedurationand/orintensity.The results ofclonogeneticassaysshowedthatcirculatinghemopoieticprogenitors increased afteracuteexercisebutdecreasedafterprolongedexercise,suggesting peripheral utilizationofbonemarrow-derivedcellsduringprolongedexercise- related stress. (literal)
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