http://www.cnr.it/ontology/cnr/individuo/prodotto/ID102843
Release of hemopoietic and endothelial progenitors after endurance and maximal exercise in runners. (Abstract/Poster in atti di convegno)
- Type
- Label
- Release of hemopoietic and endothelial progenitors after endurance and maximal exercise in runners. (Abstract/Poster in atti di convegno) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
- Alternative label
M.R. BONSIGNORE 1; G. MORICI 2; R. RICCIONI 3; V. RITI 3; E. PETRUCCI 3; L. PASQUINI 3;
A. BONANNO 4; A. PATERNO' 1; A. HUERTAS 5; L. CHIMENTI 1; M. VECA 2; V. BELLIA 1;
P. PALANGE 5; U. TESTA 3 (2007)
Release of hemopoietic and endothelial progenitors after endurance and maximal exercise in runners.
in ERS Annual Congress 2007, Stockolm, Sweden, September 15-9, 2007
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- M.R. BONSIGNORE 1; G. MORICI 2; R. RICCIONI 3; V. RITI 3; E. PETRUCCI 3; L. PASQUINI 3;
A. BONANNO 4; A. PATERNO' 1; A. HUERTAS 5; L. CHIMENTI 1; M. VECA 2; V. BELLIA 1;
P. PALANGE 5; U. TESTA 3 (literal)
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- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1Dpt. ofMed,Pneumol,PhysiolandNutrition,University
of Palermo,Palermo,Italy; 2Dpt. ofExpMed,UniversityofPalermo,Palermo,
Italy; 3Dpt ofMedicalOncology,NatlInstofHealth(ISS),Rome,Italy; 4Inst
of BiomedicineandMolecularImmunol,NationalResearchCouncil(CNR),
Palermo,Italy; 5Dpt. ofClinicalMedicine,\"LaSapienza\"Univ,Rome,Italy (literal)
- Titolo
- Release of hemopoietic and endothelial progenitors after endurance and maximal exercise in runners. (literal)
- Abstract
- Release ofbonemarrow-derivedprogenitorsdiffersbetweenendurance(Bon-
signore etal,JApplPhysiol2002)andpowerathletes(Moricietal,AmJPhysiol
2005). Weinvestigatedhemopoieticandangiogeneticprogenitorreleaseinrunners
after the2005PalermoMarathon(n=9,meanage±SD: 44±12 yr,training:88±35
km/wk) andaftermaximalexercise(1500mrunning,n=7,VO2peak:45±6
ml/min/kg). Venousbloodwasobtainedatrestand5-10minpost-exercise,and
hemopoietic progenitorswereevaluatedbyflowcytometry(CD34+,CD133+)and
clonogeneticassays(BFU-E,CFU-GM,CFU-GEMM).Angiogeneticprogenitors
wereassessedbyflowcytometryasVE-cadherin+CD133+,VEGFR2+CD34+
cells orcirculatingangiogeniccells(CAC).Afterthemarathon,totalCD34+
cells wereunchangedandclonogeneticassaysshoweda50-60%decreaseinthe
number ofhemopoieticcolonies.After1500mrunning,CD34+cellsdoubledand
BFU-E, CFU-GM,CFU-GEMMincreased.VEGFR2+CD34+cellsincreasedby
1.5-fold afterbothmarathonandmaximalexercise.CACreleasewasmoremarked
after themarathon(+333±192%) thanaftermaximalexercise(+162±70%), while
release ofVE-cadherin+CD133+cellsshowedanoppositebehaviour(+139±83 vs
+285±132%). Thesechangeswereassociatedwithreleaseofangiogeneticgrowth
factors.Therefore,intrainedrunnersexercisecausedsignificantmobilizationof
angiogeneticprogenitorsmodulatedbyexercisedurationand/orintensity.The
results ofclonogeneticassaysshowedthatcirculatinghemopoieticprogenitors
increased afteracuteexercisebutdecreasedafterprolongedexercise,suggesting
peripheral utilizationofbonemarrow-derivedcellsduringprolongedexercise-
related stress. (literal)
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