Neural correlates of anosognosia for cognitive impairment in Alzheimer's disease (Articolo in rivista)

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  • Neural correlates of anosognosia for cognitive impairment in Alzheimer's disease (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Salmon E.1, Perani D. 2, Herholz K. 3,4, Marique P. 1, Kalbe E. 3,4, Holthoff V. 5, Delbeuck X. 1, Beuthien-Baumann B. 6, Pelati O. 3,4, Lespagnard S. 1, Collette F. 1, Garraux G.1 (2006)
    Neural correlates of anosognosia for cognitive impairment in Alzheimer's disease
    in Human brain mapping (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Salmon E.1, Perani D. 2, Herholz K. 3,4, Marique P. 1, Kalbe E. 3,4, Holthoff V. 5, Delbeuck X. 1, Beuthien-Baumann B. 6, Pelati O. 3,4, Lespagnard S. 1, Collette F. 1, Garraux G.1 (literal)
Pagina inizio
  • 588 (literal)
Pagina fine
  • 597 (literal)
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  • Si tratta di uno studio di ricerca ottenuto grazie al supporto del V framework dell’Unione Europea (NEST-DD), in collaborazione con l’Università Vita-Salute San Raffaele, con l’Università di Liegi, con il Hammersmith Hospital di Londra, con l’Università di Colonia, con l’Università di Dresda e con l’Università di Cambridge.L’impact factor della rivista che ha pubblicato l’articolo è pari a 4.317. (literal)
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  • 27 (literal)
Rivista
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  • Lo studio descritto in questo articolo esplora il substrato neurale del fenomeno dell’anosognosia relativa al disturbo cognitivo in pazienti con malattia di Alzheimer (Alzheimer’s Disease: AD). 209 pazienti con demenza sono stati studiati per valutare la presenza di anosognosia, e i soggetti sono anche stati sottoposti ad una PET con 18F-FDG per valutare il metabolismo cerebrale. I risultati ottenuti dimostrano che un’errata valutazione del proprio quadro cognitivo corrisponde ad un ipometabolismo selettivo delle regioni orbitofrontali e temporali mediali, e alla giunzione temporoparietale, in accordo con teorie che identificano in queste regioni cerebrali aree cruciali per processi di autoriferimento in pazienti con demenza. (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • 1. Cyclotron Research Centre, University of Liege, Liege (Belgium) 2. Vita Salute San Raffaele University, Institute of Bioimaging and Molecular Physiology, CNR, IRCCS Hospital San Raffaele, Milano 3. Department of Neurology, University of Cologne, Cologne (Germany) 4. Max-Planck Institute for Neurological Research, Cologne (Germany) 5. Department of Psychiatry and Psychotherapy, Dresden University of Technology, Dresden (Germany) 6. Department of Nuclear Medicine, Dresden University of Technology and PET-Center, Research Center Rossendorf, Dresden (Germany) (literal)
Titolo
  • Neural correlates of anosognosia for cognitive impairment in Alzheimer's disease (literal)
Abstract
  • We explored the neural substrate of anosognosia for cognitive impairment in Alzheimer's disease (AD). Two hundred nine patients with mild to moderate dementia and their caregivers assessed patients' cognitive impairment by answering a structured questionnaire. Subjects rated 13 cognitive domains as not impaired or associated with mild, moderate, severe, or very severe difficulties, and a sum score was calculated. Two measures of anosognosia were derived. A patient's self assessment, unconfounded by objective measurements of cognitive deficits such as dementia severity and episodic memory impairment, provided an estimate of impaired self-evaluative judgment about cognition in AD. Impaired self-evaluation was related to a decrease in brain metabolism measured with 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) in orbital prefrontal cortex and in medial temporal structures. In a cognitive model of anosognosia, medial temporal dysfunction might impair a comparison mechanism between current information on cognition and personal knowledge. Hypoactivity in orbitofrontal cortex may not allow AD patients to update the qualitative judgment associated with their impaired cognitive abilities. Caregivers perceived greater cognitive impairments than patients did. The discrepancy score between caregiver's and patient's evaluations, an other measure of anosognosia, was negatively related to metabolic activity located in the temporoparietal junction, consistent with an impairment of self-referential processes and perspective taking in AD. (literal)
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