Orbitofrontal Dysfunction Related to Both Apathy and Disinhibition in Frontotemporal Dementia (Articolo in rivista)

Type
Label
  • Orbitofrontal Dysfunction Related to Both Apathy and Disinhibition in Frontotemporal Dementia (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Peters F. 1, Perani D. 2, Herholz K. 3, Holthoff V. 4, Beuthien-Baumann B. 5, Sorbi S. 6, Pupi A. 7, Degueldre C. 1, Lemaire C. 1, Collette F. 1, Salmon E. 1 (2006)
    Orbitofrontal Dysfunction Related to Both Apathy and Disinhibition in Frontotemporal Dementia
    in Dementia and geriatric cognitive disorders
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Peters F. 1, Perani D. 2, Herholz K. 3, Holthoff V. 4, Beuthien-Baumann B. 5, Sorbi S. 6, Pupi A. 7, Degueldre C. 1, Lemaire C. 1, Collette F. 1, Salmon E. 1 (literal)
Pagina inizio
  • 373 (literal)
Pagina fine
  • 379 (literal)
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  • Si tratta di uno studio di ricerca ottenuto grazie alla collaborazione con l’Università Vita-Salute San Raffaele e con l’Università di Liegi. L’impact factor della rivista che ha pubblicato l’articolo è pari a 2.603. (literal)
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  • 21 (literal)
Rivista
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  • Il lavoro descritto in questo articolo studia pazienti con variante frontale della demenza frontotemporale (frontal variant of frontotemporal dementia: fv-FTD). Le manifestazioni comportamentali tipiche di questo disturbo consentono di dividere i pazienti in due gruppi, apatetici e disinibiti: obiettivo degli autori di questo lavoro è individuare le relazioni esistenti tra il metabolismo cerebrale (tipicamente ridotto in sede orbitofrontale nei pazienti con fv-FTD) e i due spettri clinici descritti. I dati hanno dimostrato una correlazione tra il metabolismo in sede orbitofrontale posteriore ed il punteggio a scale specifiche per misurare disinibizione e apatia.Si conclude quindi che le stesse aree tipicamente coinvolte in questo disordine sono alla base delle manifestazioni comportamentali associate. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. Cyclotron Research Center, University of Liège, Liège, Belgium 2. Vita Salute San Raffaele University, and IRCCS H San Raffaele, IBFM-CNR, Milan, Italy 3. Department of Neurology, University of Cologne, and Max-Planck Institute for Neurological Research, Cologne, Germany 4. Department of Psychiatry and Psychotherapy, Dresden University of Technology, Dresden, Germany 5. Department of Nuclear Medicine, Dresden University of Technology, and PET Center, Research Center Rossendorf, Dresden, Germany 6. Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy 7. Department of Physiopathology, University of Florence, Florence, Italy (literal)
Titolo
  • Orbitofrontal Dysfunction Related to Both Apathy and Disinhibition in Frontotemporal Dementia (literal)
Abstract
  • Orbitofrontal metabolic impairment is characteristic of the frontal variant of frontotemporal dementia (fv-FTD), as are early changes in emotional and social conduct. Two main types of behavioral disturbances have been distinguished in fv-FTD patients: apathetic and disinhibited manifestations. In this study, we searched for relationships between brain metabolism and presence of apathetic or disinhibited behavior. Metabolic activity and behavioral data were collected in 41 fv-FTD patients from European PET centers. A conjunction analysis of the PET data showed an expected impairment of metabolic activity in the anterior cingulate, ventromedial and orbital prefrontal cortex, the dorsolateral prefrontal cortex and the left anterior insula in fv-FTD subjects compared to matched controls. A correlation was observed between disinhibition scores on the Neuropsychiatric Inventory scale and a cluster of voxels located in the posterior orbitofrontal cortex (6, 28, -24). Comparison of brain activity between apathetic and nonapathetic fv-FTD patients from two centers also revealed a specific involvement of the posterior orbitofrontal cortex in apathetic subjects (4, 22, -22). The results confirm that the main cerebral metabolic impairment in fv-FTD patients affects areas specializing in emotional evaluation and demonstrate that decreased orbitofrontal activity is related to both disinhibited and apathetic syndromes in fv-FTD. (literal)
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