Repeated treatment with the synthetic cannabinoid WIN 55,212-2 reduces both hyperalgesia and production of pronociceptive mediators in a rat model of neuropathic pain (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Repeated treatment with the synthetic cannabinoid WIN 55,212-2 reduces both hyperalgesia and production of pronociceptive mediators in a rat model of neuropathic pain (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Alternative label

• Costa B. 1, Colleoni M. 2, Conti S. 1, Trovato A.E. 1, Bianchi M. 2, Sotgiu M.L. 3, Giagnoni G. 1 (2004)
  Repeated treatment with the synthetic cannabinoid WIN 55,212-2 reduces both hyperalgesia and production of pronociceptive mediators in a rat model of neuropathic pain
  in British journal of pharmacology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Costa B. 1, Colleoni M. 2, Conti S. 1, Trovato A.E. 1, Bianchi M. 2, Sotgiu M.L. 3, Giagnoni G. 1 (literal)

Pagina inizio

• 4 (literal)

Pagina fine

• 8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Research devoted to the advancement of pain therapy (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 141 (literal)

Rivista

• British journal of pharmacology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• Corresponding author: B. Costa (barbara.costa@unimib.it). Citazioni al 26/01/09: 27 Citazioni al 2007: 22 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 Department of Biotechnology and Bioscience, University of Milan-Bicocca, Milan, Italy 2 Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Milan, Italy 3 Institute of Bioimages and Molecular Physiology, CNR, Segrate (M)), Italy (literal)

Titolo

• Repeated treatment with the synthetic cannabinoid WIN 55,212-2 reduces both hyperalgesia and production of pronociceptive mediators in a rat model of neuropathic pain (literal)

Abstract

• The antinociceptive properties of cannabinoids in persistent pain are not fully elucidated. We investigated the effect of repeated treatment with the synthetic cannabinoid receptor agonist WIN 55,212-2 on the neuropathic pain induced in rats by chronic constriction of the sciatic nerve. WIN 55,212-2 administered daily throughout the development of neuropathy reversed the hyperalgesia, at a dose (0.1 mg x kg(-1), s.c.) that had no effect on the nociceptive responses of either paw contralateral to the sciatic ligation or of animals subjected to sham surgery. At 14 days after injury, the levels of mediators known to be involved in neuropathic pain, such as prostaglandin E2, NO and the neuronal NOS, were increased. Repeated treatment with WIN 55,212-2 abolished these increases. In the light of the current clinical need for neuropathic pain treatments, these findings indicate that cannabinoid agonists, at doses devoid of psychoactive effects, could constitute important compounds for the development of new analgesics. (literal)

Prodotto di

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)

Autore CNR

• MARIA LUISA SOTGIU (Persona)

Insieme di parole chiave

• Parole chiave di "Repeated treatment with the synthetic cannabinoid WIN 55,212-2 reduces both hyperalgesia and production of pronociceptive mediators in a rat model of neuropathic pain" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)

Autore CNR di

• MARIA LUISA SOTGIU (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• British journal of pharmacology (Rivista)

Insieme di parole chiave di

• Parole chiave di "Repeated treatment with the synthetic cannabinoid WIN 55,212-2 reduces both hyperalgesia and production of pronociceptive mediators in a rat model of neuropathic pain" (Insieme di parole chiave)