Efficacy of nociceptin inhibition on WDR neuron activity is enhanced in mononeuropathic rats (Articolo in rivista)

Type
Label
  • Efficacy of nociceptin inhibition on WDR neuron activity is enhanced in mononeuropathic rats (Articolo in rivista) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.brainres.2003.11.025 (literal)
Alternative label
  • Sotgiu M,L. 1, Bellomi P. 1, Biella G.E. 1 (2004)
    Efficacy of nociceptin inhibition on WDR neuron activity is enhanced in mononeuropathic rats
    in Brain research
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Sotgiu M,L. 1, Bellomi P. 1, Biella G.E. 1 (literal)
Pagina inizio
  • 251 (literal)
Pagina fine
  • 254 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • Research devoted to the advancement of pain therapy (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 998 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto Bioimmagini e Fisiologia Molecolare-CNR, Segrate (Mi), Italy (literal)
Titolo
  • Efficacy of nociceptin inhibition on WDR neuron activity is enhanced in mononeuropathic rats (literal)
Abstract
  • Nociceptin (NC), administered microiontophoretically at different concentrations, significantly reduced the spontaneous and stimulus-evoked activity on WDR neuron in rats with chronic constriction of one sciatic nerve and showing signs of neuropathic pain. The effect was not antagonized by Naloxone. The same concentrations of NC were ineffective on the noxious stimulus evoked responses of WDR neurons in sham and intact rats. This result indicates a facilitated inhibitory action of NC on nociceptive transmission in this pain model. (literal)
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