Improved synthesis and radiolabeling of [(11)C]MP4A, a suitable ligand for the investigation of the cholinergic system using PET (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Improved synthesis and radiolabeling of [(11)C]MP4A, a suitable ligand for the investigation of the cholinergic system using PET (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Alternative label

• Carpinelli A. 1, Magni F. 2, Cattaneo A. 2, Matarrese M. 1, Turolla E. 1, Todde S. 1, Bosso N. 2, Galli Kienle M. 2, Fazio F. 1 (2006)
  Improved synthesis and radiolabeling of [(11)C]MP4A, a suitable ligand for the investigation of the cholinergic system using PET
  in Applied radiation and isotopes
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Carpinelli A. 1, Magni F. 2, Cattaneo A. 2, Matarrese M. 1, Turolla E. 1, Todde S. 1, Bosso N. 2, Galli Kienle M. 2, Fazio F. 1 (literal)

Pagina inizio

• 182 (literal)

Pagina fine

• 186 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 64 (literal)

Rivista

• Applied radiation and isotopes (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. IBFM-CNR, Scientific Institute, University of Milano Bicocca, H S. Raffaele, Milano, Italy 2. DIMESAB, University of Milano Bicocca, Monza (MI), Italy (literal)

Titolo

• Improved synthesis and radiolabeling of [(11)C]MP4A, a suitable ligand for the investigation of the cholinergic system using PET (literal)

Abstract

• An improved synthesis of the precursor acetic acid-piperidine-4-yl ester by acetylation of 4-hydroxypiperidine hydrochloride in anhydrous chloroform was developed. A procedure for fast evaluation and characterization of products originated by acetylation of the 4-piperidinol using LC-APCI/MS with an acetonitrile-water gradient method on a Merck Purosphere RP-18 column was also developed. The highly purified precursor allowed the production of [11C]MP4A for PET studies of acetylcholine neurotransmission system. The tracer was produced with >98% radiochemical purity, with yields ranging 20-60% (decay-corrected) from EOB. (literal)

Prodotto di

• Sviluppo di radiofarmaci ad uso medico (ME.P06.006.001) (Modulo)
• Institute of molecular bioimaging and physiology (IBFM) (Istituto)

Autore CNR

• SERGIO CAMILLO TODDE (Persona)
• ELIA ANNA TUROLLA (Persona)
• MARIZA GALLI KIENLE (Persona)
• ASSUNTA CARPINELLI (Persona)
• FERRUCCIO FAZIO (Unità di personale esterno)
• MARIO MATARRESE (Persona)

Insieme di parole chiave

• Parole chiave di "Improved synthesis and radiolabeling of [(11)C]MP4A, a suitable ligand for the investigation of the cholinergic system using PET" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ASSUNTA CARPINELLI (Persona)
• MARIO MATARRESE (Persona)
• ELIA ANNA TUROLLA (Persona)
• MARIZA GALLI KIENLE (Persona)
• SERGIO CAMILLO TODDE (Persona)
• FERRUCCIO FAZIO (Unità di personale esterno)

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Sviluppo di radiofarmaci ad uso medico (ME.P06.006.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Applied radiation and isotopes (Rivista)

Insieme di parole chiave di

• Parole chiave di "Improved synthesis and radiolabeling of [(11)C]MP4A, a suitable ligand for the investigation of the cholinergic system using PET" (Insieme di parole chiave)