The mGluR5 selective antagonist 6-methyil-2 (phenylethynyl)-pyridine reduces the spinsal neuron pain-related activity in mononeuropathic rats (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• The mGluR5 selective antagonist 6-methyil-2 (phenylethynyl)-pyridine reduces the spinsal neuron pain-related activity in mononeuropathic rats (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• Sotgiu M.L., Bellomi P., Biella G.E. (2003)
  The mGluR5 selective antagonist 6-methyil-2 (phenylethynyl)-pyridine reduces the spinsal neuron pain-related activity in mononeuropathic rats
  in Neuroscience letters (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Sotgiu M.L., Bellomi P., Biella G.E. (literal)

Pagina inizio

• 85 (literal)

Pagina fine

• 88 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 342 (literal)

Rivista

• Neuroscience letters (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• The mGluR5 selective antagonist 6-methyil-2 (phenylethynyl)-pyridine reduces the spinsal neuron pain-related activity in mononeuropathic rats (literal)

Abstract

• In rats with chronic constriction of one sciatic nerve (CCI rats), showing behavioural signs of neuropathic pain, 6-methyl-2-(phenylethynyl)-pyridine (MPEP), a selective mGluR5 antagonist, was intraperitoneally administered at 0.75, 1.0 and 1.5 mg/kg or spinally microejected and the effects on the lumbar wide dynamic range neurons activity were investigated. In CCI rats MPEP at 1.0 and 1.5 (but not at 0.75) mg/kg, or spinally microejected induced a significant reduction of the spontaneous (SA) and noxious evoked activity (NEA), and a significant decrease of the suppression of the afterdischarge duration. In sham rats SA was unaffected and NEA was significantly reduced by 1.0 and 1.5 mg/kg MPEP dosages. These findings indicate that the metabotropic GluR5 receptor plays a role in the spinal cord processes underlying neuropathic pain and represents a potential target for new therapeutic approaches. (literal)

Prodotto di

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)

Autore CNR

• MARIA LUISA SOTGIU (Persona)
• GABRIELE BIELLA (Unità di personale interno)

Incoming links:

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)

Autore CNR di

• GABRIELE BIELLA (Unità di personale interno)
• MARIA LUISA SOTGIU (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neuroscience letters (Rivista)