Calcium accumulation in neurites and cell bodies of rat cerebellar granule cells in culture: effects on GABA-A receptor function. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Calcium accumulation in neurites and cell bodies of rat cerebellar granule cells in culture: effects on GABA-A receptor function. (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Alternative label

• Cupello A. 1, Esposito A. 2, Marchetti C. 3, Pellistri F. 2, Robello M. 2 (2005)
  Calcium accumulation in neurites and cell bodies of rat cerebellar granule cells in culture: effects on GABA-A receptor function.
  in Amino acids (Wien, Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Cupello A. 1, Esposito A. 2, Marchetti C. 3, Pellistri F. 2, Robello M. 2 (literal)

Pagina inizio

• 177 (literal)

Pagina fine

• 182 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 28 (literal)

Rivista

• Amino acids (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Istituto di Bioimmagini e Fisiologia Molecolare, CNR, Sezione di Genova, Genova, Italy 2. INFM, Dipartimento di Fisica, Università di Genova, Genova, Italy 3. Istituto di Biofisica, CNR, Genova, Italy (literal)

Titolo

• Calcium accumulation in neurites and cell bodies of rat cerebellar granule cells in culture: effects on GABA-A receptor function. (literal)

Abstract

• Accumulation of calcium in rat cerebellar granule cells in culture was studied by two photon laser scanning microscopy. Depolarizations by high extracellular potassium induced short-lived increases in calcium in both cell bodies and neurites. However, although the increase in neurites subsided completely after the initial peak, in cell bodies there was a persistent plateau until the high potassium stimulus was removed. On the contrary, the calcium signal due to NMDA receptors activation was persistent in both cell bodies and neurites and remained until the agonist was present.The nature of these calcium signals provides an interpretation key for the effects of NMDA receptors activation on GABA(A) receptors. In particular, the persistent calcium increase in neurites may explain the decrease in GABA activated chloride currents which are related to activation of dendritic/synaptic GABA(A) receptors. (literal)

Prodotto di

• Neurofisiopatologia e clinica (ME.P02.003.001) (Modulo)
• Institute of molecular bioimaging and physiology (IBFM) (Istituto)

Autore CNR

• AROLDO CUPELLO (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Calcium accumulation in neurites and cell bodies of rat cerebellar granule cells in culture: effects on GABA-A receptor function." (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Neurofisiopatologia e clinica (ME.P02.003.001) (Modulo)

Autore CNR di

• AROLDO CUPELLO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Amino acids (Rivista)

Insieme di parole chiave di

• Parole chiave di "Calcium accumulation in neurites and cell bodies of rat cerebellar granule cells in culture: effects on GABA-A receptor function." (Insieme di parole chiave)