Increased 5-HT2 receptor binding in frontal cortex of depressed patients responding to paroxetine treatment: a PET scan study. (Articolo in rivista)

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  • Increased 5-HT2 receptor binding in frontal cortex of depressed patients responding to paroxetine treatment: a PET scan study. (Articolo in rivista) (literal)
Anno
  • 2001-01-01T00:00:00+01:00 (literal)
Alternative label
  • Zanardi R. 1., Artigas . F. 2, Moresco R.M. 3, Colombo C. 1, Messa C. 3, Gobbo C 3., Smeraldi E . 1, Fazio F. 3 (2001)
    Increased 5-HT2 receptor binding in frontal cortex of depressed patients responding to paroxetine treatment: a PET scan study.
    in Journal of clinical psychopharmacology
    (literal)
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  • Zanardi R. 1., Artigas . F. 2, Moresco R.M. 3, Colombo C. 1, Messa C. 3, Gobbo C 3., Smeraldi E . 1, Fazio F. 3 (literal)
Pagina inizio
  • 53 (literal)
Pagina fine
  • 58 (literal)
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  • Impact Factor: 4.250 (literal)
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  • 21 (literal)
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  • Il lavoro descrive i dati di una ricerca focalizzata sullo studio in vivo mediante PET dell’espressione dei recettori per la serotonina di tipo 5HT2a in pazienti con depressione maggiore. Per lo studio sono stati reclutati pazienti con depressione maggiore unipolare in terapia con l’antidepressivo paroxetina. I pazienti sono stati studiati mediante PET a 4-6 settimane dall’inizio del trattamento e la risposta clinica (scala di Hamilton) correlata all’espressione recettoriale. I risultati della ricerca indicano che i pazienti che non mostrano miglioramento clinico alla scala di Hamilton avevano un’ espressione recettoriale significativamente inferiore ai soggetti con buona risposta clinica alla terapia con paroxetina. L’espressione dei recettori 5HT2a potrebbe rappresentare un marcatore in vivo di stato di patologia. In oltre alla luce delle ultime ipotesi biologiche, la riduzione recettoriale osservata nei pazienti con scarsa risposta clinica potrebbe riflettere un diverso stato trofico dei neuroni piramidali corticali. (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • 1. Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, School of Medicine, University of Milan, Milan, Italy. 2. Department of Neurochemistry, Instituto de Investigaciones Biomedicas de Barcelona, CSIC-IDIBAPS, Barcelona, Spain. 3. INB-CNR, Istituto Scientifico Ospedale San Raffaele, Department of Nuclear Medicine, University of Milan Bicocca, Milan, Italy (literal)
Titolo
  • Increased 5-HT2 receptor binding in frontal cortex of depressed patients responding to paroxetine treatment: a PET scan study. (literal)
Abstract
  • The changes in aminergic receptors elicited by antidepressant treatments have been extensively examined in the brain of experimental animals using radioligand and molecular techniques. However, there is a very limited direct information regarding the changes effected by such treatments in the human brain, as well as its relationship to clinical improvement. Using positron emission tomography (PET) scanning, the authors examined the cortical 5-Hydroxytryptamine-2A (5-HT2A) receptor binding of [18F]fluoro-ethyl-spiperone after a 4-week treatment with the selective serotonin reuptake inhibitor paroxetine. [18F]fluoro-ethyl-spiperone labels 5-HT2A receptors in the cortex and dopamine D2 receptors in the basal ganglia. A binding index (BI) was calculated in the frontal cortex and the basal ganglia (mostly caudate-putamen) by reference to cerebellum. Thirty-seven inpatients with major depression with a mean +/- SD score on the 21-item Hamilton Rating Scale for Depression (HAM-D-21) of 26.3 +/- 4.3 at admission were treated with paroxetine 40 mg/day. After 4 weeks of treatment, the BI in the frontal cortex of remitted patients (HAM-D-21 score = 4.7 +/- 4.0; N = 20) was significantly greater than the score in nonresponder patients (HAM-D-21 score = 21.2 +/- 4.0; N = 17) (BI = 0.54 +/- 0.15 and 0.41 +/- 0.17, respectively; p < 0.02). No such difference was observed in the basal ganglia (5.45 +/- 1.11 and 5.39 +/- 0.82, respectively; p = 0.85). The significant difference in cortical BI persisted when age was used as covariate (p < 0.016). These data suggest that clinical improvement in patients treated with paroxetine is associated with an increase in the density of 5-HT2A receptors in the frontal cortex. (literal)
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