Ethanol inhibits the binding of substance P to rat brain cortex NK1 receptors. (Articolo in rivista)

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Label
  • Ethanol inhibits the binding of substance P to rat brain cortex NK1 receptors. (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • Scarrone S., Cappelli A., Cupello A., Matarrese M., Moresco R.M., Fazio F. (2003)
    Ethanol inhibits the binding of substance P to rat brain cortex NK1 receptors.
    in Neurochemical research
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Scarrone S., Cappelli A., Cupello A., Matarrese M., Moresco R.M., Fazio F. (literal)
Pagina inizio
  • 1159 (literal)
Pagina fine
  • 1162 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 28 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • Ethanol inhibits the binding of substance P to rat brain cortex NK1 receptors. (literal)
Abstract
  • The binding of 125I-labeled substance P (SP) to rat brain cortex membranes has been studied under control conditions and in the presence of ethanol. The binding of SP at low concentrations (20-1000 pM) gave two components, one with a KD value of 80 pM and another one with a KD of 500 pM. The higher-affinity component is due to NK1 receptors, as confirmed by the inhibition of the SP binding by the rodent NK1 specific agonist [Sar9 Met(O2)11]SP. Ethanol (1.7 mM) added to the binding assays inhibited by more than 50% the specific binding at a very low SP concentration (20 pM); however, it had no effect at SP concentrations ranging from 50 to 120 pM. This suggests a decrease by ethanol of the affinity of SP to the NK1 receptors involved in this binding component. The ethanol effect disappeared at [EtOH] < or = 0.17 mM. (literal)
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