http://www.cnr.it/ontology/cnr/individuo/prodotto/ID10051
Changes of autonomic cardiac profile after a 3-week integrated body weifgt reduction program in severely obese patients (Articolo in rivista)
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- Changes of autonomic cardiac profile after a 3-week integrated body weifgt reduction program in severely obese patients (Articolo in rivista) (literal)
- Anno
- 2003-01-01T00:00:00+01:00 (literal)
- Alternative label
Facchini M., Malfatto G., Sala L., Silvestri G., Fontana P., Lafortuna C.L., Sartorio A. (2003)
Changes of autonomic cardiac profile after a 3-week integrated body weifgt reduction program in severely obese patients
in Journal of endocrinological investigation (Testo stamp.)
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- Facchini M., Malfatto G., Sala L., Silvestri G., Fontana P., Lafortuna C.L., Sartorio A. (literal)
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- Titolo
- Changes of autonomic cardiac profile after a 3-week integrated body weifgt reduction program in severely obese patients (literal)
- Abstract
- The autonomic control of the heart is abnormal in obese subjects due to a prevalence of sympathetic over parasympathetic limb of the autonomic balance. We evaluated the effects of a short-term (3 weeks) integrated body weight reduction program (consisting of energy restricted diet and high-intensity exercise training) on heart rate variability (HRV) in severely obese, normotensive patients. The HRV was evaluated both in the time and frequency domain over a 18-hour Holter recording period obtained before and at the end of the third week. Three-week body weight reduction program reduced BMI (from 41.4 +/- 4.6 to 39.5 +/- 4.3 kg/m2, -4.6%, p<0.0001) and heart rate (from 77.8 +/- 8.6 to 73.6 +/- 8.7 b/min, p=0.0003). Significant changes in the autonomic profile were observed both in the time and frequency domain (SD of RR interval, SDRR: +16.1%; mean squared successive difference: (MSSD) +16.7%; percentage of RR intervals differing more than 50 msec from the preceding one, pNN50: +31.8%; low frequency oscillation, LF: +17.1%; high frequency oscillation, HF: +/- 18.2%). In conclusion, this study demonstrates that a short-term, integrated body weight reduction program is able to favorably modify the autonomic profile in a population of normotensive, severely obese subjects. The reduction of heart rate and the increase in parasympathetic activity may consistently contribute to a reduction of the risk of cardiovascular morbidity and of sudden cardiac death, still high in this patients' group. (literal)
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