http://www.cnr.it/ontology/cnr/individuo/modulo/ID8561
Progetto AIRC: MiRNAs in tumorigenesis: novel oncosuppressor targets and miRNA-mediated control of AP-1 transcription factors (SV.P15.007.002)
- Type
- Label
- Progetto AIRC: MiRNAs in tumorigenesis: novel oncosuppressor targets and miRNA-mediated control of AP-1 transcription factors (SV.P15.007.002) (literal)
- Codice
- Anno di chiusura previsto
- 2013-01-01T00:00:00+01:00 (literal)
- Istituto esecutore
- Abstract
- Several tumor-associated miRNAs have been characterized as components of regulatory feedback loops involving oncogenic and oncosuppressor transcription factors, such as Myc, NF-kB and p53. MiRNAs, in turn, can control the synthesis of their own transactivators, by both direct and indirect mechanisms forming complex regulatory networks.
The AP-1 transcription factors are key targets of multiple tumorigenic pathways. The oncogenic role of AP-1 is complex, because of the large number of homo- and hetero- dimers formed by JUN and FOS family members, which play distinct, sometimes antagonistic functions, depending on the cell-context.
Recently, in an in vitro system of thyroid cell transformation, we have reported that the miR-21 precursor (pri-miR-21) is transcriptionally regulated by AP-1 in response to the RAS oncoprotein.
In this project, we will:
- identify novel tumor suppressor targets of miR-21 in multiple tumor cell lines;
- characterize the mechanisms of miRNA-mediated regulation of various AP-1 components in neoplastic transformation;
- adopt high-throughput approaches, based on AP-1-regulated reporters as readouts for functional screening of miRNAs affecting AP-1 activity. (literal)
- Nome
- Progetto AIRC: MiRNAs in tumorigenesis: novel oncosuppressor targets and miRNA-mediated control of AP-1 transcription factors (literal)
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- Modulo di
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