http://www.cnr.it/ontology/cnr/individuo/modulo/ID7462
Segnali cellulari critici nella biologia della cellula neoplastica (SV.P17.008.002)
- Type
- Label
- Segnali cellulari critici nella biologia della cellula neoplastica (SV.P17.008.002) (literal)
- Prodotto
- Resistance to diverse apoptotic triggers in multidrug resistant HL60 cells and its possible relationship to the expression of P-glycoprotein, Fas and of the novel anti-apoptosis factors IAP (inhibitory of apoptosis proteins) (Articolo in rivista) (Prodotto della ricerca)
- The protein tyrosine kinase JAK1 complements defects in interferon-a/b and -g signal transduction. (Articolo in rivista) (Prodotto della ricerca)
- Splicing defect in RFXANK results in a moderate combined immunodeficiency and long-duration clinical course. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Gene expression profiling of human liver cancer cells following celecoxib treatment. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Altered gene expression profiles in liver cancer cells upon sorafenib treatment. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Diverse roles of GSK-3: Tumor promoter-tumor suppressor, target in cancer therapy. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Molecular mechanisms of sorafenib action in liver cancer cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- GSK-3 as potential target for therapeutic irvention in cancer. (Articolo in rivista) (Prodotto della ricerca)
- Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells (Articolo in rivista) (Prodotto della ricerca)
- Management of liver failure: from transplantation to cell-based therapy. (Articolo in rivista) (Prodotto della ricerca)
- UTILIZZO DI OPENLDAP COME BACKEND PER LAUTENTICAZIONE CENTRALIZZATA DEGLI UTENTI (Rapporti tecnici, manuali, carte geologiche e tematiche e prodotti multimediali) (Prodotto della ricerca)
- OPENMEETINGS: UNA SOLUZIONE OPEN SOURCE PER VIDEOCONFERENZE (Rapporti tecnici, manuali, carte geologiche e tematiche e prodotti multimediali) (Prodotto della ricerca)
- Roles of signaling pathways in drug resistance, cancer initiating cells and cancer progression and metastasis (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Non invasive tools for the diagnosis of liver cirrhosis (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Inhibition of GSK-3 beta activity can result in drug and hormonal resistance and alter sensitivity to targeted therapy in breast cancer (Abstract in rivista) (Prodotto della ricerca)
- Multifaceted roles of GSK-3 and Wnt/beta-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- GSK-3beta is a critical mediator of tetrandrine induced cell cycle arrest and cytotoxicity. (Articolo in rivista) (Prodotto della ricerca)
- Circulating E-selectin levels in chronic hepatitis C patients with normal or elevated transaminase before and after alpha-interferon treatment. (Articolo in rivista) (Prodotto della ricerca)
- Microgravity and cellular homeostasis:effects of stimulated hypogravity on FRTL-5 thyroid cells. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Cyclooxygenase-2 expression in chronic liver disease and hepatocellular carcinoma: an immunohistochemical study. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Role of the PI3K/PTEN/AKT/mTOR pathway in breast cancer drug resistance and sensitivity to targeted therapy. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Correlation between neutrofil associated lipocalin (NGAL) and matrix metalloproteinase-9 (MMP-9) levels in hepatocellular carcinoma development. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- DHMEQ, a novel NF-kb inhibitor, anticancer activity through induction of reactive oxygen species-dependent mechanism in human hepatoma cells. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Targeting cancer stem cells - Lancing their Achilles heel. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Roles of proliferative and metastatic pathways in chemotherapeutic drug resistance and cancer stem cells-sites for therapeutic intervention (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Cyclooxygenase-2, Tumor Necrosis Factor-±, Vascular Endothelial Growth factor-A and IL-6 genes SNPS and Il-6 serum levels in liver cirrhosis and hepatocellular carcinoma. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Antitumor effects of the selective cyclooxygenase-1 inhibitor SC-560 is potentiated by inhibiton of MEK/ERK pathway in human hepatocellular carcinoma cells. (Contributo in atti di convegno) (Prodotto della ricerca)
- Nanoparticelle lipidiche solide cationiche come vettori del DNA. (Contributo in atti di convegno) (Prodotto della ricerca)
- Serum concentration of E-selectin in patients with chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Advances in targeting signal transduction pathways. (Articolo in rivista) (Prodotto della ricerca)
- Transcriptional regulation of miR-224 upregulated in human HCCs by NFkB inflammatory pathways. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Phosphorylation-dependent regulation of skeletogenesis in sea urchin micromere-derived cells and embryos. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Cloning and expression of a type IX-like collagen in tissues of the ascidian Ciona intestinalis. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- New Agents and Approaches for Targeting the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR Cell Survival Pathways (Contributo in volume (capitolo o saggio)) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1201)
- Association between single nucleotide polymorphisms in the cyclooxygenase-2, tumor necrosis factor-±, and vascular endothelial growth factor-A genes, and susceptibility to hepatocellular carcinoma. (Articolo in rivista) (Prodotto della ricerca)
- Frequent Alteration of the Yin Yang 1/Raf-1 Kinase Inhibitory Protein Ratio in Hepatocellular Carcinoma. (Articolo in rivista) (Prodotto della ricerca)
- Isoforms of the class II transactivator protein. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- IP-deltaEx10-11: a novel splice variant of the apoptosis inhibitor NAIP differently expressed in drug-sensitive and multidrug-resistant HL60 leukemia cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Truncated form of beta-catenin and reduced expression of wild-type catenins feature HepG2 human liver cancer cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Targeted therapy for hepatocellular carcinoma: novel agents on the horizon. (Articolo in rivista) (Prodotto della ricerca)
- The novel NF-kB inhibitor DHMEQ synergizes with celecoxib to exert antitumor effects on human liver cancer cells by a ROS-dependent mechanism. (Articolo in rivista) (Prodotto della ricerca)
- Targeting breast cancer initiating cells: Advances in breast cancer research and therapy. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Mutation in the class II trans-activator leading to a mild immunodeficiency. (Articolo in rivista) (Prodotto della ricerca)
- Novel combination of sorafenib and celecoxib provides synergistic anti-proliferative and pro-apoptotic effects in human liver cancer cells. (Articolo in rivista) (Prodotto della ricerca)
- GRP78 POLYMORPHISM rs430397 IS ASSOCIATED WITH HEPATOCELLULAR CARCINOMA IN A SOUTHERN ITALIAN POPULATION (Abstract in rivista) (Prodotto della ricerca)
- Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. (Articolo in rivista) (Prodotto della ricerca)
- Novel combination of celecoxib and proteasome inhibitor MG132 provides synergistic antiproliferative and proapoptotic effects in human liver tumor cells. Cell Cycle. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Emerging MEK inhibitors. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- IL-6 -174G/C polymorphism and IL-6 serum levels in patients with liver cirrhosis and hepatocellular carcinoma. (Articolo in rivista) (Prodotto della ricerca)
- COX-2-Dependent and COX-2-Independent Mode of Action of Celecoxib in Human Liver Cancer Cells. (Articolo in rivista) (Prodotto della ricerca)
- Effects of human leukocyte antigen (HLA)-DR engagement on melanoma cells. (Articolo in rivista) (Prodotto della ricerca)
- Epidemiology, risk factors, and natural history of hepatocellular carcinoma (Articolo in rivista) (Prodotto della ricerca)
- MHC calls II-deficient tumor cell lines with a defective expression of the class II transactivator (Articolo in rivista) (Prodotto della ricerca)
- Drug resistance, signaling pathways: roles for in cancer stem cells? (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Association between single nucleotide polymorphisms in the COX-2, TNF-± and VEGF-A genes, and susceptibility to hepatocellular carcinoma (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- IL-6 -174G®C polymorphism and IL-6 serum levels in patients with liver cirrhosis and hepatocellular carcinoma. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Circulating IL-6 and sil-6R in patients with hepatocellular carcinoma. (Articolo in rivista) (Prodotto della ricerca)
- Frequent alteration of the Yin Yang/Raf-1 kinase inhibitory protein ratio in hepatocellular carcinoma. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Signalling of the major histocompatibility complex (MHC) class II molecules in melanoma cells. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Growth suppression and apoptosis induction in human hepatoma cells by DHMEQ, a novel NF-KB inhibitor, is mediated through a ROS-dependent mechanism. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Nanoassemblies of amphiphilic cyclodextrin and tributyltin(IV) complexes of meso-tetra (4-sulfonatophenyl)porphine: spectroscopy, release and cytotoxicity on human melanoma cells. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Constitutive expression of MHC class II genes in melanoma cell lines results from the transcription of class II transactivator abnormally initiated from its B cell-specific promoter. (Articolo in rivista) (Prodotto della ricerca)
- Altered gene expression profiles in liver cancer cells upon sorafenib treatment. (Abstract/Poster in convegno) (Prodotto della ricerca)
- Combination of DHMEQ and Celecoxib synergistically exert anti-tumoral effects in human hepatoma cells. (Abstract/Poster in convegno) (Prodotto della ricerca)
- Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130 (Articolo in rivista) (Prodotto della ricerca)
- The multikinase inhibitor Sorafenib exhibits a strong cytotoxic effect in liver cancer cells through a MEK/ERK signaling-independent mechanism (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- DHMEQ and Celecoxib synergistically exert anti-tumoral activities in human liver cancer cells. (Abstract/Poster in convegno) (Prodotto della ricerca)
- Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components. (Articolo in rivista) (Prodotto della ricerca)
- The novel NF-kB inhibitor DHMEQ suppresses the growth of human hepatic cancer cells through redox-dependent signaling. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Activation of the protein tyrosine kinase tyk2 by interferon alpha/beta. (Articolo in rivista) (Prodotto della ricerca)
- Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon a/b and for signal trasduction. (Articolo in rivista) (Prodotto della ricerca)
- Effects of Liraglutide on Carotid Intima-Media Thickness in Patients with Type-2 Diabetes and Non-Alcoholic Fatty Liver Disease: An 8-Month Prospective Pilot Study (Abstract in rivista) (Prodotto della ricerca)
- Suppressing prostate cancer by targeting NGAL (Abstract in rivista) (Prodotto della ricerca)
- Poly (ADP-ribose) polymerase inhibition synergizes with the NF-kB inhibitor DHMEQ to kill hepatocellular carcinoma cells (Articolo in rivista) (Prodotto della ricerca)
- Corrigendum to \"Poly (ADP-ribose) polymerase inhibition synergizes with the NF-?B inhibitor DHMEQ to kill hepatocellular carcinoma cells\" [Biochim. Biophys. Acta 1843 (2014) 2662-2673] (Articolo in rivista) (Prodotto della ricerca)
- Targeting signaling pathways in prostate cancer (Abstract/Comunicazione in rivista) (Prodotto della ricerca)
- Targeting the cancer initiating cell: the ultimate target for cancer therapy. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Nanotechnology applications for the therapy of liver fibrosis (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- REALIZZAZIONE DI UNINFRASTRUTTURA PER LACCESSO ALLA RETE WIRELESS EDUROAM (Rapporti tecnici, manuali, carte geologiche e tematiche e prodotti multimediali) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1715)
- Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The tumor microenvironment in hepatocellular carcinoma (Articolo in rivista) (Prodotto della ricerca)
- Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance. (Articolo in rivista) (Prodotto della ricerca)
- Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity. (Articolo in rivista) (Prodotto della ricerca)
- Three novel mutations of the CIITA gene in MHC class II-deficient patients with a severe immunodeficiency. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Transcriptional regulation of signature miRNAs (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Cationic Solid-lipid nanoparticles as DNA carriers. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Influence of MEK/ERK signaling on apoptosis induced by selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatocellular carcinoma cells. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Combination of the selective COX-2 inhibitor Celecoxib and the proteasome inibitor MG132 synergistically induces anti-proliferative and pro-apoptotic activity in liver cancer cells: possible involvement of endoplasmic reticulum stress response. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Hepatic expression of cycloxygenase-2 in non-alcoholic fatty liver disease. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Potentiation of antitumor effects of NSAIDs by inhibition of MEK/ERK activity in human hepatocellular carcinoma cells. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Emerging Raf inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- The selective COX-1 inhibitor SC-560 suppresses cell growth and induces apoptosis in human hepatocellular carcinoma cells. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Significance of autologous Interleukin 6 production in the HA22T/VGH cell model of hepatocellular carcinoma. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Inhibition of MEK/ERK pathway enhances apoptosis induced by selective COX-1 and COX-2 inhibitors in human hepatocellular carcinoma cells. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Apoptosis and cell growth arrest in A375 human melanoma cells by diorganotin(IV) and triorganotin(IV) complexes of [meso-Tetra(4-sulfonatophenyl)porhine] manganese(III)chloride (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The amino-terminal region of Tyk2 sustains the level of interferon a receptor 1, a component of the interferon a/b receptor. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Sex hormones and risk of liver tumors (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Solid-lipid nanoparticles for gene delivery to cells. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Combination treatment with celecoxib and DHMEQ or curcumin results in synergistic cell growth inhibition in hepatic cancer cells. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Prostaglandin E2 receptors and COX enzymes in human hepatocellular carcinoma: role in the regulation of cell growth. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- The selective COX-1 inhibitor SC-560 inhibits cell growth and induces apoptosis in human hepatocellular carcinoma cells. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Antitumor effects of curcumin and its combination with cisplatin or doxorubicin on hepatic cancer cells: possible relationship to NF-kB activation and IAP gne expression. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Antitumor effects of the NF-kB inhibitors curcumin and DHMEQ, alone or combine with cisplatin, on hepatic cancer cells. Analysis of their relationship to IL-6 production. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Aromatase and amphiregulin are correspondingly espressed in human liver cancer cells. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Transcriptional regulation of micro-RNAs highly expressed in human HCCS (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Micro-RNA signature of human hepatocellular carcinoma (HCC). (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Circulating intercellular adhesion molecule-1 in patients with hepatocellular carcinoma. (Articolo in rivista) (Prodotto della ricerca)
- Spontaneous cytotoxic activity of eosinophilic granule cells separated from the normal peritoneal cavity of Dicentrarchus labrax. (Articolo in rivista) (Prodotto della ricerca)
- Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Phosphorylation-dependent regulation of axon fasciculation. (Articolo in rivista) (Prodotto della ricerca)
- Codice
- Anno di chiusura previsto
- 2017-01-01T00:00:00+01:00 (literal)
- Istituto esecutore
- Primo anno di attività
- 2009-01-01T00:00:00+01:00 (literal)
- Abstract
- CONTINUAZIONE COMMESSA SV.P15.005.001
Il trattamento del carcinoma epatocellulare (HCC) e del melanoma con le terapie esistenti non si è rivelato ad oggi del tutto soddisfacente, ciò enfatizza la necessità di sviluppare nuove strategie terapeutiche per il loro trattamento. In questo studio utilizzeremo farmaci che agiscono inibendo pathway cellulari importanti per la sopravvivenza e la proliferazione della cellula tumorale, allo scopo di valutare se determinate combinazioni possono essere proposte per il trattamento dell'HCC. Sarà inoltre valutata la possibilità di superare la resistenza dell'HCC ai chemioterapici convenzionali. Le cellule di melanoma acquisiscono spesso la capacità di sfuggire al controllo del sistema immunitario probabilmente tramite uno scambio di segnali tra le cellule tumorali e quelle del sistema immunitario. Il melanoma è inoltre resistente all'azione della chemioterapia, di conseguenza studieremo i segnali attivati nelle cellule di melanoma per deviare la risposta immune verso la progressione tumorale e i segnali mediati da alcuni derivati della porfirina per inibire la crescita delle cellule di melanoma allo scopo di sviluppare una terapia più efficace. (literal)
- Nome
- Segnali cellulari critici nella biologia della cellula neoplastica (literal)
- Descrizione
- Modulo di
- Gestore
Incoming links:
- Prodotto di
- The selective COX-1 inhibitor SC-560 inhibits cell growth and induces apoptosis in human hepatocellular carcinoma cells. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Antitumor effects of curcumin and its combination with cisplatin or doxorubicin on hepatic cancer cells: possible relationship to NF-kB activation and IAP gne expression. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Antitumor effects of the NF-kB inhibitors curcumin and DHMEQ, alone or combine with cisplatin, on hepatic cancer cells. Analysis of their relationship to IL-6 production. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Sex hormones and risk of liver tumors (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Solid-lipid nanoparticles for gene delivery to cells. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Combination treatment with celecoxib and DHMEQ or curcumin results in synergistic cell growth inhibition in hepatic cancer cells. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Prostaglandin E2 receptors and COX enzymes in human hepatocellular carcinoma: role in the regulation of cell growth. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Aromatase and amphiregulin are correspondingly espressed in human liver cancer cells. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Transcriptional regulation of micro-RNAs highly expressed in human HCCS (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Micro-RNA signature of human hepatocellular carcinoma (HCC). (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Antitumor effects of the selective cyclooxygenase-1 inhibitor SC-560 is potentiated by inhibiton of MEK/ERK pathway in human hepatocellular carcinoma cells. (Contributo in atti di convegno) (Prodotto della ricerca)
- Nanoparticelle lipidiche solide cationiche come vettori del DNA. (Contributo in atti di convegno) (Prodotto della ricerca)
- Microgravity and cellular homeostasis:effects of stimulated hypogravity on FRTL-5 thyroid cells. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Cyclooxygenase-2 expression in chronic liver disease and hepatocellular carcinoma: an immunohistochemical study. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Role of the PI3K/PTEN/AKT/mTOR pathway in breast cancer drug resistance and sensitivity to targeted therapy. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- DHMEQ, a novel NF-kb inhibitor, anticancer activity through induction of reactive oxygen species-dependent mechanism in human hepatoma cells. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Cloning and expression of a type IX-like collagen in tissues of the ascidian Ciona intestinalis. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Isoforms of the class II transactivator protein. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Novel combination of celecoxib and proteasome inhibitor MG132 provides synergistic antiproliferative and proapoptotic effects in human liver tumor cells. Cell Cycle. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Emerging MEK inhibitors. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- IL-6 -174G/C polymorphism and IL-6 serum levels in patients with liver cirrhosis and hepatocellular carcinoma. (Articolo in rivista) (Prodotto della ricerca)
- COX-2-Dependent and COX-2-Independent Mode of Action of Celecoxib in Human Liver Cancer Cells. (Articolo in rivista) (Prodotto della ricerca)
- Effects of human leukocyte antigen (HLA)-DR engagement on melanoma cells. (Articolo in rivista) (Prodotto della ricerca)
- Resistance to diverse apoptotic triggers in multidrug resistant HL60 cells and its possible relationship to the expression of P-glycoprotein, Fas and of the novel anti-apoptosis factors IAP (inhibitory of apoptosis proteins) (Articolo in rivista) (Prodotto della ricerca)
- Splicing defect in RFXANK results in a moderate combined immunodeficiency and long-duration clinical course. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- GSK-3beta is a critical mediator of tetrandrine induced cell cycle arrest and cytotoxicity. (Articolo in rivista) (Prodotto della ricerca)
- Circulating E-selectin levels in chronic hepatitis C patients with normal or elevated transaminase before and after alpha-interferon treatment. (Articolo in rivista) (Prodotto della ricerca)
- Association between single nucleotide polymorphisms in the cyclooxygenase-2, tumor necrosis factor-±, and vascular endothelial growth factor-A genes, and susceptibility to hepatocellular carcinoma. (Articolo in rivista) (Prodotto della ricerca)
- Frequent Alteration of the Yin Yang 1/Raf-1 Kinase Inhibitory Protein Ratio in Hepatocellular Carcinoma. (Articolo in rivista) (Prodotto della ricerca)
- Circulating IL-6 and sil-6R in patients with hepatocellular carcinoma. (Articolo in rivista) (Prodotto della ricerca)
- Epidemiology, risk factors, and natural history of hepatocellular carcinoma (Articolo in rivista) (Prodotto della ricerca)
- MHC calls II-deficient tumor cell lines with a defective expression of the class II transactivator (Articolo in rivista) (Prodotto della ricerca)
- Constitutive expression of MHC class II genes in melanoma cell lines results from the transcription of class II transactivator abnormally initiated from its B cell-specific promoter. (Articolo in rivista) (Prodotto della ricerca)
- Three novel mutations of the CIITA gene in MHC class II-deficient patients with a severe immunodeficiency. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Emerging Raf inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Apoptosis and cell growth arrest in A375 human melanoma cells by diorganotin(IV) and triorganotin(IV) complexes of [meso-Tetra(4-sulfonatophenyl)porhine] manganese(III)chloride (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Management of liver failure: from transplantation to cell-based therapy. (Articolo in rivista) (Prodotto della ricerca)
- Potentiation of antitumor effects of NSAIDs by inhibition of MEK/ERK activity in human hepatocellular carcinoma cells. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- The selective COX-1 inhibitor SC-560 suppresses cell growth and induces apoptosis in human hepatocellular carcinoma cells. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Significance of autologous Interleukin 6 production in the HA22T/VGH cell model of hepatocellular carcinoma. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Inhibition of MEK/ERK pathway enhances apoptosis induced by selective COX-1 and COX-2 inhibitors in human hepatocellular carcinoma cells. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Cationic Solid-lipid nanoparticles as DNA carriers. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Influence of MEK/ERK signaling on apoptosis induced by selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatocellular carcinoma cells. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Combination of the selective COX-2 inhibitor Celecoxib and the proteasome inibitor MG132 synergistically induces anti-proliferative and pro-apoptotic activity in liver cancer cells: possible involvement of endoplasmic reticulum stress response. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Hepatic expression of cycloxygenase-2 in non-alcoholic fatty liver disease. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Transcriptional regulation of signature miRNAs (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Nanoassemblies of amphiphilic cyclodextrin and tributyltin(IV) complexes of meso-tetra (4-sulfonatophenyl)porphine: spectroscopy, release and cytotoxicity on human melanoma cells. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Signalling of the major histocompatibility complex (MHC) class II molecules in melanoma cells. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Growth suppression and apoptosis induction in human hepatoma cells by DHMEQ, a novel NF-KB inhibitor, is mediated through a ROS-dependent mechanism. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Drug resistance, signaling pathways: roles for in cancer stem cells? (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Association between single nucleotide polymorphisms in the COX-2, TNF-± and VEGF-A genes, and susceptibility to hepatocellular carcinoma (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- IL-6 -174G®C polymorphism and IL-6 serum levels in patients with liver cirrhosis and hepatocellular carcinoma. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Frequent alteration of the Yin Yang/Raf-1 kinase inhibitory protein ratio in hepatocellular carcinoma. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- The novel NF-kB inhibitor DHMEQ suppresses the growth of human hepatic cancer cells through redox-dependent signaling. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- DHMEQ and Celecoxib synergistically exert anti-tumoral activities in human liver cancer cells. (Abstract/Poster in convegno) (Prodotto della ricerca)
- Altered gene expression profiles in liver cancer cells upon sorafenib treatment. (Abstract/Poster in convegno) (Prodotto della ricerca)
- Combination of DHMEQ and Celecoxib synergistically exert anti-tumoral effects in human hepatoma cells. (Abstract/Poster in convegno) (Prodotto della ricerca)
- The multikinase inhibitor Sorafenib exhibits a strong cytotoxic effect in liver cancer cells through a MEK/ERK signaling-independent mechanism (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Correlation between neutrofil associated lipocalin (NGAL) and matrix metalloproteinase-9 (MMP-9) levels in hepatocellular carcinoma development. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Targeting cancer stem cells - Lancing their Achilles heel. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Roles of proliferative and metastatic pathways in chemotherapeutic drug resistance and cancer stem cells-sites for therapeutic intervention (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Cyclooxygenase-2, Tumor Necrosis Factor-±, Vascular Endothelial Growth factor-A and IL-6 genes SNPS and Il-6 serum levels in liver cirrhosis and hepatocellular carcinoma. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Gene expression profiling of human liver cancer cells following celecoxib treatment. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Altered gene expression profiles in liver cancer cells upon sorafenib treatment. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- UTILIZZO DI OPENLDAP COME BACKEND PER LAUTENTICAZIONE CENTRALIZZATA DEGLI UTENTI (Rapporti tecnici, manuali, carte geologiche e tematiche e prodotti multimediali) (Prodotto della ricerca)
- OPENMEETINGS: UNA SOLUZIONE OPEN SOURCE PER VIDEOCONFERENZE (Rapporti tecnici, manuali, carte geologiche e tematiche e prodotti multimediali) (Prodotto della ricerca)
- REALIZZAZIONE DI UNINFRASTRUTTURA PER LACCESSO ALLA RETE WIRELESS EDUROAM (Rapporti tecnici, manuali, carte geologiche e tematiche e prodotti multimediali) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1715)
- Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Targeting the cancer initiating cell: the ultimate target for cancer therapy. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The tumor microenvironment in hepatocellular carcinoma (Articolo in rivista) (Prodotto della ricerca)
- Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance. (Articolo in rivista) (Prodotto della ricerca)
- Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity. (Articolo in rivista) (Prodotto della ricerca)
- Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Molecular mechanisms of sorafenib action in liver cancer cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Transcriptional regulation of miR-224 upregulated in human HCCs by NFkB inflammatory pathways. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The novel NF-kB inhibitor DHMEQ synergizes with celecoxib to exert antitumor effects on human liver cancer cells by a ROS-dependent mechanism. (Articolo in rivista) (Prodotto della ricerca)
- Targeted therapy for hepatocellular carcinoma: novel agents on the horizon. (Articolo in rivista) (Prodotto della ricerca)
- Advances in targeting signal transduction pathways. (Articolo in rivista) (Prodotto della ricerca)
- New Agents and Approaches for Targeting the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR Cell Survival Pathways (Contributo in volume (capitolo o saggio)) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1201)
- Spontaneous cytotoxic activity of eosinophilic granule cells separated from the normal peritoneal cavity of Dicentrarchus labrax. (Articolo in rivista) (Prodotto della ricerca)
- Circulating intercellular adhesion molecule-1 in patients with hepatocellular carcinoma. (Articolo in rivista) (Prodotto della ricerca)
- Phosphorylation-dependent regulation of axon fasciculation. (Articolo in rivista) (Prodotto della ricerca)
- The amino-terminal region of Tyk2 sustains the level of interferon a receptor 1, a component of the interferon a/b receptor. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The protein tyrosine kinase JAK1 complements defects in interferon-a/b and -g signal transduction. (Articolo in rivista) (Prodotto della ricerca)
- IP-deltaEx10-11: a novel splice variant of the apoptosis inhibitor NAIP differently expressed in drug-sensitive and multidrug-resistant HL60 leukemia cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Truncated form of beta-catenin and reduced expression of wild-type catenins feature HepG2 human liver cancer cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Novel combination of sorafenib and celecoxib provides synergistic anti-proliferative and pro-apoptotic effects in human liver cancer cells. (Articolo in rivista) (Prodotto della ricerca)
- Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon a/b and for signal trasduction. (Articolo in rivista) (Prodotto della ricerca)
- Activation of the protein tyrosine kinase tyk2 by interferon alpha/beta. (Articolo in rivista) (Prodotto della ricerca)
- Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components. (Articolo in rivista) (Prodotto della ricerca)
- Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130 (Articolo in rivista) (Prodotto della ricerca)
- Mutation in the class II trans-activator leading to a mild immunodeficiency. (Articolo in rivista) (Prodotto della ricerca)
- Serum concentration of E-selectin in patients with chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Phosphorylation-dependent regulation of skeletogenesis in sea urchin micromere-derived cells and embryos. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Diverse roles of GSK-3: Tumor promoter-tumor suppressor, target in cancer therapy. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Nanotechnology applications for the therapy of liver fibrosis (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Multifaceted roles of GSK-3 and Wnt/beta-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- GSK-3 as potential target for therapeutic irvention in cancer. (Articolo in rivista) (Prodotto della ricerca)
- Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells (Articolo in rivista) (Prodotto della ricerca)
- Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. (Articolo in rivista) (Prodotto della ricerca)
- Poly (ADP-ribose) polymerase inhibition synergizes with the NF-kB inhibitor DHMEQ to kill hepatocellular carcinoma cells (Articolo in rivista) (Prodotto della ricerca)
- Corrigendum to \"Poly (ADP-ribose) polymerase inhibition synergizes with the NF-?B inhibitor DHMEQ to kill hepatocellular carcinoma cells\" [Biochim. Biophys. Acta 1843 (2014) 2662-2673] (Articolo in rivista) (Prodotto della ricerca)
- Non invasive tools for the diagnosis of liver cirrhosis (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Roles of signaling pathways in drug resistance, cancer initiating cells and cancer progression and metastasis (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Inhibition of GSK-3 beta activity can result in drug and hormonal resistance and alter sensitivity to targeted therapy in breast cancer (Abstract in rivista) (Prodotto della ricerca)
- Targeting breast cancer initiating cells: Advances in breast cancer research and therapy. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Effects of Liraglutide on Carotid Intima-Media Thickness in Patients with Type-2 Diabetes and Non-Alcoholic Fatty Liver Disease: An 8-Month Prospective Pilot Study (Abstract in rivista) (Prodotto della ricerca)
- Suppressing prostate cancer by targeting NGAL (Abstract in rivista) (Prodotto della ricerca)
- Targeting signaling pathways in prostate cancer (Abstract/Comunicazione in rivista) (Prodotto della ricerca)
- GRP78 POLYMORPHISM rs430397 IS ASSOCIATED WITH HEPATOCELLULAR CARCINOMA IN A SOUTHERN ITALIAN POPULATION (Abstract in rivista) (Prodotto della ricerca)
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