http://www.cnr.it/ontology/cnr/individuo/modulo/ID5788
Studio dell'espressione e della funzione di geni e proteine coinvolte nel diabete di tipo 2 (SV.P16.001.002)
- Type
- Label
- Studio dell'espressione e della funzione di geni e proteine coinvolte nel diabete di tipo 2 (SV.P16.001.002) (literal)
- Prodotto
- Peroxisome proliferator-activated receptor-? activation enhances insulin-stimulated glucose disposal by reducing ped/pea-15 gene expression in skeletal muscle cells: evidence for involvement of activator protein-1. (Articolo in rivista) (Prodotto della ricerca)
- Bisphenol A in polycystic ovary syndrome and its association with liver-spleen axis. (Articolo in rivista) (Prodotto della ricerca)
- A functional allelic variant of the FGF23 gene is associated with renal phosphate leak in calcium nephrolithiasis. (Articolo in rivista) (Prodotto della ricerca)
- Evidence for evolutionary and nonevolutionary forces shaping the distribution of human genetic variants near transcription start sites (Articolo in rivista) (Prodotto della ricerca)
- Adenoviral Gene Transfer of PLD1-D4 Enhances Insulin Sensitivity in Mice by Disrupting Phospholipase D1 Interaction with PED/PEA-15. (Articolo in rivista) (Prodotto della ricerca)
- Identification and functional characterization of a novel mutation in the NKX2-1 gene: comparison with the data in the literature. (Articolo in rivista) (Prodotto della ricerca)
- Anandamide Drives Cell Cycle Progression through CB1 Receptors in a Rat Model of Synchronized Liver Regeneration. (Articolo in rivista) (Prodotto della ricerca)
- Genome-wide scan for signatures of human population differentiation and their relationship with natural selection, functional pathways and diseases. (Articolo in rivista) (Prodotto della ricerca)
- N6-isopentenyladenosine affects cytotoxic activity and cytokines production by IL-2 activated NK cells and exerts topical anti-inflammatory activity in mice (Articolo in rivista) (Prodotto della ricerca)
- Statins in neurological disorders: An overview and update (Articolo in rivista) (Prodotto della ricerca)
- Interaction of endocannabinoid system and steroid hormones in the control of colon cancer cell growth. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Rimonabant reduces keratinocyte viability by induction of apoptosis and exerts topical anti-inflammatory activity in mice. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- PED/PEA-15 controls fibroblast motility and wound closure by ERK1/2-dependent mechanisms. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- PED/PEA-15 inhibits hydrogen peroxide-induced apoptosis in Ins-1E pancreatic beta-cells via PLD-1 (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The plant hormone abscisic acid increases in human plasma after hyperglycemia and stimulates glucose consumption by adipocytes and myoblasts. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and of Ras farnesylation mediate antitumor effects of anandamide in human breast cancer cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Rimonabant (SR141716) induces metabolism and acquisition of fertilizing ability in human sperm. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Synergistic inhibition of human colon cancer cell growth by the cannabinoid CB1 receptor antagonist rimonabant and oxaliplatin. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Human sperm anatomy: ultrastructural localization of the cannabinoid1 receptor and a potential role of anandamide in sperm survival and acrosome reaction. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Prep1 controls insulin glucoregulatory function in liver by transcriptional targeting of SHP1 tyrosine phosphatase. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Increased levels of theAkt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Early and late events induced by polyq-expanded proteins: identification of a common pathogenic property of polyq-expanded proteins. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The repressor element 1-silencing transcription factor is a novel molecular target for the neurotoxic effect of the polychlorinated biphenyl mixture aroclor 1254 in neuroblastoma SH-SY5Y cells. (Articolo in rivista) (Prodotto della ricerca)
- The CB1 receptor antagonist rimonabant controls cell viability and ascitic tumour growth in mice. (Articolo in rivista) (Prodotto della ricerca)
- Upregulation of miR-21 by Ras in vivo and its role in tumor growth. (Articolo in rivista) (Prodotto della ricerca)
- Cytotoxicity of dental resin composites: an in vitro evaluation. (Articolo in rivista) (Prodotto della ricerca)
- Signs of selective pressure on genetic variants affecting human height. (Articolo in rivista) (Prodotto della ricerca)
- Shorter telomeres in patients with cerebral autosomal dominant arteriopathy and leukoencephalopathy (CADASIL) (Articolo in rivista) (Prodotto della ricerca)
- Age-related impairment in insulin release: the essential role of ?(2)-adrenergic receptor. (Articolo in rivista) (Prodotto della ricerca)
- PED/PEA-15 induces autophagy and mediates TGF-beta1 effect on muscle cell differentiation. (Articolo in rivista) (Prodotto della ricerca)
- Cell fate following ER stress: just a matter of \"quo ante\" recovery or death? (Articolo in rivista) (Prodotto della ricerca)
- Association between Cannabinoid type-1 receptor polymorphism and body mass index in a Southern Italian population. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Antiangiogenetic activity of the endocannabinoid anandamide.Correlation to its tumour-suppressor efficacy (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Thrombin-activated platelets induce proliferation of human skin fibroblasts by stimulating autocrine production of insulin-like growth factor-1. (Articolo in rivista) (Prodotto della ricerca)
- Beta2-adrenergic receptor and UCP3 variants modulate the relationship between age and type 2 diabetes mellitus. (Articolo in rivista) (Prodotto della ricerca)
- Understanding type 2 diabetes: from genetics to epigenetics (Articolo in rivista) (Prodotto della ricerca)
- Peptide antagonists of the PED-hPLD1 binding (Articolo in rivista) (Prodotto della ricerca)
- Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The PPAR?2 Pro12Ala variant is protective against progression of nephropathy in people with type 2 diabetes (Articolo in rivista) (Prodotto della ricerca)
- GRP78 Mediates Cell Growth and Invasiveness in Endometrial Cancer. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 1,2-Dihydro-2-oxopyridine-3-carboxamides: The C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The anandamide analogue, Met-F-AEA, controls human breast cancer cell migration via the RhoA/Rho kinase signaling pathway. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Rimonabant (SR141716) exerts anti-proliferative and immunomodulatory effects in human peripheral blood mononuclear cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Leptin induces mitogenic effect on human choriocarcinoma cell line (JAr) via MAP kinase activation in a glucose-dependent fashion. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Accurancy of clinical diagnostic criteria for Friedreichs ataxia (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Recombinant Human Erythropoietin Increases Frataxin Protein Expression Without Increasing mRNA Expression. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Pro12Ala polymorphism of the PPAR gamma 2 locus modulates the relationship between energy intake and body weight in type2 diabetic patients. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Triplet repeat instability correlates with dinucleotide instability in primary breast cancer. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- A distinct group of CpG islands shows differential DNA methylation between replicas of the same cell line in vitro. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- N6-isopentenyladenosine, an endogenous isoprenoid end product, directly affects cytotoxic and regulatory functions of human NK cells through FDPS modulation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Residues 762-801 of PLD1 mediate the interaction with PED/PEA15 (Articolo in rivista) (Prodotto della ricerca)
- Anandamide inhibits the Wnt/?-catenin signalling pathway in human breast cancer MDA MB 231 cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Cannabinoid receptor CB1 antagonists state of the art and challenges. (Articolo in rivista) (Prodotto della ricerca)
- A new role of anandamide in human sperm: focus on metabolism. (Articolo in rivista) (Prodotto della ricerca)
- lo stress del reticolo endoplasmatico (RE) indotto da glucosammina inibisce l'espressione del GLUT4 nelle cellule muscolari scheletriche mediante il fattore di attivazione della trscrizione (ATF) 6 (Altre pubblicazioni) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1717)
- Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions in the mouse colon (Articolo in rivista) (Prodotto della ricerca)
- Il fattore di trascrizione nucleare epatico HNF-4alpha è responsabile della repressione \"epigenetica\" del gene umano PED. (Altre pubblicazioni) (Prodotto della ricerca)
- Endocannabinoids as emergine suppressors of angiogenesis and tumor invasion (Articolo in rivista) (Prodotto della ricerca)
- Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma (Articolo in rivista) (Prodotto della ricerca)
- Higher farnesyl diphosphate synthase activity in human colorectal cancer inhibition of cellular apoptosis. (Articolo in rivista) (Prodotto della ricerca)
- HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway (Articolo in rivista) (Prodotto della ricerca)
- FUNCTIONAL CHARACTERIZATION OF A NEW MUTATION IN THE NKX2.1 IN PATIENTS WITH \"THYROID-LUNG-BRAIN SYNDROME. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Hyperglycaemia enhances the expression of the diabetogene ped/pea-15 through chromatin remodelling. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- PGC-1alpha down-regulation affects the antioxidant response in Friedreich's ataxia. (Articolo in rivista) (Prodotto della ricerca)
- Loss of the CBX7 protein expression correlates with a more aggressive phenotype in pancreatic cancer. (Articolo in rivista) (Prodotto della ricerca)
- Molecular cloning and characterization of the human Ped/Pea-15 gene promoter reveals antagonistic regulation by HNF-4alpha and COUP-TFII. (Articolo in rivista) (Prodotto della ricerca)
- Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells. (Articolo in rivista) (Prodotto della ricerca)
- Glucose regulates diacylglycerol intracellular levels and protein kinase C activity by modulating diacylglycerol-kinase subcellular localization. (Articolo in rivista) (Prodotto della ricerca)
- Somatic instability of the expanded GAA triplet-repeat sequence in Friedreich ataxia progresses throughout life. (Articolo in rivista) (Prodotto della ricerca)
- Effects of anandamide on polyamine levels and cell growth in human colon cancer cells. (Articolo in rivista) (Prodotto della ricerca)
- Involvement of Akt/NF-ºB pathway in N6-isopentenyladenosine-induced apoptosis in human breast cancer cells. (Articolo in rivista) (Prodotto della ricerca)
- Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines. (Articolo in rivista) (Prodotto della ricerca)
- CONDIZIONI INFIAMMATORIE ASSOCIATE AL DIABETE TIPO 2 ALTERANO LA REGOLAZIONE EPIGENETICA DEL GENE PREP1 (Contributo in atti di convegno) (Prodotto della ricerca)
- Hyperglycemia enhances the expression of the diabetogene ped/pea-15 through chromatin remodelling. (Contributo in atti di convegno) (Prodotto della ricerca)
- From anecdotal evidences of cannabinoids in multiple sclerosis to emerging new therapeutical approaches. (Articolo in rivista) (Prodotto della ricerca)
- INSULIN REGULATES TYROSINE HYDROXYLASE EXPRESSION IN NEURONAL PC12 CELLS. (Contributo in atti di convegno) (Prodotto della ricerca)
- The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes. (Articolo in rivista) (Prodotto della ricerca)
- Involvement of protein kinase B and mitogen-activated protein kinases in experimental normothermic liver ischaemia-reperfusion injury. (Articolo in rivista) (Prodotto della ricerca)
- Alterations in protein tyrosine kinase pathways in rat liver following (Articolo in rivista) (Prodotto della ricerca)
- A novel mutation in SACS gene in a family from southern Italy (Articolo in rivista) (Prodotto della ricerca)
- Replication mediated instability of the GAA triplet repeat mutation in Friedreich ataxia (Articolo in rivista) (Prodotto della ricerca)
- Ataxia with oculomotor apraxia type 1 in Southern Italy: late onset and variable phenotype. (Articolo in rivista) (Prodotto della ricerca)
- PED/PEA-15 regulates glucose-induced insulin secretion by restraining potassium channel expression in pancreatic beta-cells. (Articolo in rivista) (Prodotto della ricerca)
- Inverted duplication of 15q with terminal deletion in a multiple malformed newborn with intrauterine growth failure and lethal phenotype. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Update on the endocannabinoid system as an anticancer target. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- CpG islands undermethylation in human genomic regions under selective pressure. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Inflammatory conditions associated to type 2 diabetes cause Prep-1 gene overexpression by inducing epigenetic modifications on its promoter region (Contributo in atti di convegno) (Prodotto della ricerca)
- Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells. (Articolo in rivista) (Prodotto della ricerca)
- Reply to the letter to the editor (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Iodine deficiency and goiter prevalence in a population living at sea level in Campania (Italy). (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- CpG islands under selective pressure are enriched with H3K4me3, H3K27ac and H3K36me3 histone modifications. Akhtar MM, Scala G, Cocozza S, Miele G, Monticelli A. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Human Sperm Anatomy: Ultrastructural Localization of the Cannabinoid1 Receptor and a Potential Role of Anandamide in Sperm Survival and Acrosome Reaction. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- N6-isopentenyladenosine inhibits cell proliferation and induces apoptosis in a human colon cancer cell line DLD1. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Selective disruption of insulin-like growth factor (IGF)-1 signalling via phosphoinositide-dependent kinase-1 prevents the protective effect of IGF-1 on human cancer cell death. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Trischitta V, Frittitta L. ENPP1 Affects Insulin Action and Secretion: Evidences from In Vitro Studies. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The Energy intake modulates the association of the -55CT polymorphism of UCP3 with body weight in type 2 diabetic patients. (Articolo in rivista) (Prodotto della ricerca)
- Pharmacological Actions of Statins: A Critical Appraisal in the Management of Cancer. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Endoplasmic reticulum stress is activated in endometrial adenocarcinoma. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Tyr phosphatase-mediated P-ERK inhibition suppresses senescence in EIA + v-raf transformed cells, which, paradoxically, are apoptosis-protected in a MEK-dependent manner. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- ER stress impairs MHC Class I surface expression and increases susceptibility of thyroid cells to NK-mediated cytotoxicity. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Serum 25-Hydroxyvitamin D Levels, Phosphoprotein Enriched in Diabetes Gene Product (PED/PEA-15) and Leptin-to-Adiponectin Ratio in Women with PCOS. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Genetic and pharmacologic inactivation of cannabinoid CB1 receptor inhibits angiogenesis. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- ENPP1 affects insulin action and secretion: evidences from in vitro studies. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Selective disruption of insulin-like growth factor-1 (IGF-1) signaling via phosphoinositide-dependent kinase-1 prevents the protective effect of IGF-1 on human cancer cell death. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Preliminary data on effects of metformin on PED/PEA-15 cellular levels in obese women with polycystic ovary syndrome. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Rimonabant reduces keratinocyte viability by induction of apoptosis and exerts topical anti-inflammatory activity in mice. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- A new strategy to block tumor growth by inhibiting endocannabinoid inactivation (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- In adipocytes bisphenol-A down-regulates insulin sensitivity and up-regulates inflammatory pathways (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Parental imprinting of rat insulin-like growth factor II gene promoters is coordinately regulated. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells. (Articolo in rivista) (Prodotto della ricerca)
- Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The N-Terminal Domain of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase Harbors a GTP/ATP Binding Site. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Progressive GAA expansions in dorsal root ganglia of Friedreich's ataxia patients. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Anandamide inhibits adhesion and migration of breast cancer cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Cannabinoids and cancer: pros and cons of an antitumour strategy. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The Cannabinoid CB1 Receptor Antagonist Rimonabant (SR141716) Inhibits Human Breast Cancer Cell Proliferation through a Lipid Raft-Mediated Mechanism. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast cancer cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Increased hexosamine biosynthetic pathway flux dedifferentiates INS-1E cells and murine islets by an extracellular signal-regulated kinase (ERK)1/2-mediated signal transmission pathway. (Articolo in rivista) (Prodotto della ricerca)
- Atypical Friedreich ataxia phenotype associated with a novel missense mutation in the X25 gene. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- New clues on the origin of the Friedreich ataxia expanded alleles from the analysis of new polymorphisms closely linked to the mutation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Adipocyte-released insulin-like growth factor-1 is regulated by glucose and fatty acids and controls breast cancer cell growth in vitro. (Articolo in rivista) (Prodotto della ricerca)
- Mitochondrial DNA haplogroups influence the Fredreich ataxia phenotype (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Inhibition of autophagy enhances the effects of E1A-defective oncolytic adenovirus dl922-947 against glioma cells in vitro and in vivo. (Articolo in rivista) (Prodotto della ricerca)
- Real time PCR quantification of frataxin mRNA in the peripheral blood leucocytes of Friedreich ataxia patients and carriers. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Tyrosine phosphorylation of insulin receptor substrates during ischemia/reperfusion-induced apoptosis in rat liver. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Liver HIF-1 alpha induction precedes apoptosis following normothermic ischemia-reperfusion in rats. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- ER stress is associated with dedifferentiation and an epithelial-to-mesenchymal transition-like phenotype in PC Cl3 thyroid cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Early carotid atherosclerosis in normotensive severe obese premenopausal women with low DHEA(S). (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: an investigation of the 1,8-naphthyridin-2(1H)-one scaffold. (Articolo in rivista) (Prodotto della ricerca)
- Measurement of glucose homeostasis in vivo: glucose and insulin tolerance tests. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- New expectations from the well-known medicinal properties of Arctium lappa. (Articolo in rivista) (Prodotto della ricerca)
- Inhibitory effects of cannabinoid CB 1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis. (Articolo in rivista) (Prodotto della ricerca)
- PPAR-gamma agonist Azelaoyl PAF increases frataxin protein and mRNA expression: new implications for the Friedreich's ataxia therapy. (Articolo in rivista) (Prodotto della ricerca)
- Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-² activity and TGF-²1 expression. (Articolo in rivista) (Prodotto della ricerca)
- Hepatocyte nuclear factor (HNF)-4 alpha-driven epigenetic silencing of the human PED gene (Articolo in rivista) (Prodotto della ricerca)
- Tyrosine phosphorylation of insulin receptor substrates during ischemia/reperfusion-induced apoptosis in rat liver. (Articolo in rivista) (Prodotto della ricerca)
- Can Telomere Shortening in Human Peripheral Blood Leukocytes Serve as a Disease Biomarker of Friedreich's Ataxia? (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Somatic instability in Friedreich ataxia occurs after organogenesis, progresses throughout life, and includes large, age-dependent expansions in dorsal root ganglia (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Estrogenic regulation of cholesterol biosynthesis and cell growth in DLD-1 human colon cancer cells. (Articolo in rivista) (Prodotto della ricerca)
- Arvanil and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cells. (Articolo in rivista) (Prodotto della ricerca)
- A common response element mediates differential effects of phorbol esters and forskolin on type-1 plasminogen activator inhibitor gene expression in human breast carcinoma cells. (Articolo in rivista) (Prodotto della ricerca)
- Antiangiogenic effects of N6-isopentenyladenosine, an endogenous isoprenoid end product, mediated by AMPK activation. (Articolo in rivista) (Prodotto della ricerca)
- PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- N6-isopentenyladenosine improves nuclear shape in fibroblasts from humans with progeroid syndromes by inhibiting the farnesylation of prelamin A. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Immune-Modulation and Properties of Absorption and Blood Brain Barrier Permeability of 1,8-Naphthyridine Derivatives. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Lo stress del reticolo endoplasmatico (RE) indotto da glucosammina inibisce l'espressione del GLUT4 nelle cellule muscolari scheletriche mediante il fattore di attivazione della trascrizione (ATF) 6. (Articolo in rivista) (Prodotto della ricerca)
- Identification of molecular pathways involved in diabetes-associated cancers. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Endoplasmic reticulum stress in endometrial cancer. (Articolo in rivista) (Prodotto della ricerca)
- CpG islands under selective pressure are enriched with H3K4me3, H3K27ac and H3K36me3 histone modifications. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Iperglicemia e acidi grassi alterano la regolazione epigenetica del gene Prep1 (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Anandamide inhibits the Wnt/?-catenin signalling pathway in human breast cancer MDA MB 231 cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- POLYCYSTIC OVARY SYNDROME AND HEPATIC STEATOSIS: COULD LOW-GRADE CHRONIC INFLAMMATION BE MEDIATED BY THE SPLEEN? (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Methylglyoxal impairs endothelial insulin sensitivity both in vitro and in vivo. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Expression and purification of the D4 region of PLD1 and characterization of its interaction with PED-PEA15 (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Personalized medicine and type 2 diabetes: Lesson from epigenetics (Articolo in rivista) (Prodotto della ricerca)
- Codice
- Anno di chiusura previsto
- 2017-01-01T00:00:00+01:00 (literal)
- Istituto esecutore
- Primo anno di attività
- 2006-01-01T00:00:00+01:00 (literal)
- Abstract
- Il diabete tipo 2 (DM2) è determinato da alterazioni della secrezione e dell'azione insulinica. Tuttavia, sia l'origine del difetto beta-cellulare che i geni responsabili dell'insulino-resistenza rimangono sconosciuti nella maggioranza dei pazienti. L'identificazione di meccanismi potenzialmente coinvolti nell'insorgenza dell'insulino-resistenza e nell'alterazione della secrezione insulinica è perciò di enorme importanza per la comprensione della storia naturale del DM2 e per l'individuazione di nuove opportunità per il trattamento di questa malattia. L'obiettivo del modulo è quindi l'identificazione di nuovi geni potenzialmente coinvolti nella patogenesi del DM2 e delle complicanze ad esso associate e la generazione di modelli animali e linee cellulari opportuni per lo studio della funzione e della regolazione dell'espressione di questi geni e delle proteine da essi codificate. Le informazioni che deriveranno da questi studi serviranno per produrre e caratterizzare molecole in grado di regolare l'attività e/o l'espressione dei geni d'interesse, come potenziale approccio terapeutico innovativo per la cura del DM2 (literal)
- Nome
- Studio dell'espressione e della funzione di geni e proteine coinvolte nel diabete di tipo 2 (literal)
- Descrizione
- Modulo di
- Gestore
Incoming links:
- Prodotto di
- A distinct group of CpG islands shows differential DNA methylation between replicas of the same cell line in vitro. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Anandamide inhibits adhesion and migration of breast cancer cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Cannabinoids and cancer: pros and cons of an antitumour strategy. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The Cannabinoid CB1 Receptor Antagonist Rimonabant (SR141716) Inhibits Human Breast Cancer Cell Proliferation through a Lipid Raft-Mediated Mechanism. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast cancer cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Atypical Friedreich ataxia phenotype associated with a novel missense mutation in the X25 gene. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- New clues on the origin of the Friedreich ataxia expanded alleles from the analysis of new polymorphisms closely linked to the mutation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Mitochondrial DNA haplogroups influence the Fredreich ataxia phenotype (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Real time PCR quantification of frataxin mRNA in the peripheral blood leucocytes of Friedreich ataxia patients and carriers. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Tyrosine phosphorylation of insulin receptor substrates during ischemia/reperfusion-induced apoptosis in rat liver. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Liver HIF-1 alpha induction precedes apoptosis following normothermic ischemia-reperfusion in rats. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- ER stress is associated with dedifferentiation and an epithelial-to-mesenchymal transition-like phenotype in PC Cl3 thyroid cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The N-Terminal Domain of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase Harbors a GTP/ATP Binding Site. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Progressive GAA expansions in dorsal root ganglia of Friedreich's ataxia patients. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Inhibitory effects of cannabinoid CB 1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis. (Articolo in rivista) (Prodotto della ricerca)
- Early carotid atherosclerosis in normotensive severe obese premenopausal women with low DHEA(S). (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- PPAR-gamma agonist Azelaoyl PAF increases frataxin protein and mRNA expression: new implications for the Friedreich's ataxia therapy. (Articolo in rivista) (Prodotto della ricerca)
- Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-² activity and TGF-²1 expression. (Articolo in rivista) (Prodotto della ricerca)
- Hepatocyte nuclear factor (HNF)-4 alpha-driven epigenetic silencing of the human PED gene (Articolo in rivista) (Prodotto della ricerca)
- Tyrosine phosphorylation of insulin receptor substrates during ischemia/reperfusion-induced apoptosis in rat liver. (Articolo in rivista) (Prodotto della ricerca)
- Estrogenic regulation of cholesterol biosynthesis and cell growth in DLD-1 human colon cancer cells. (Articolo in rivista) (Prodotto della ricerca)
- Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells. (Articolo in rivista) (Prodotto della ricerca)
- Update on the endocannabinoid system as an anticancer target. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- CpG islands undermethylation in human genomic regions under selective pressure. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Pharmacological Actions of Statins: A Critical Appraisal in the Management of Cancer. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Endoplasmic reticulum stress is activated in endometrial adenocarcinoma. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Serum 25-Hydroxyvitamin D Levels, Phosphoprotein Enriched in Diabetes Gene Product (PED/PEA-15) and Leptin-to-Adiponectin Ratio in Women with PCOS. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Thrombin-activated platelets induce proliferation of human skin fibroblasts by stimulating autocrine production of insulin-like growth factor-1. (Articolo in rivista) (Prodotto della ricerca)
- Beta2-adrenergic receptor and UCP3 variants modulate the relationship between age and type 2 diabetes mellitus. (Articolo in rivista) (Prodotto della ricerca)
- Accurancy of clinical diagnostic criteria for Friedreichs ataxia (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Recombinant Human Erythropoietin Increases Frataxin Protein Expression Without Increasing mRNA Expression. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Pro12Ala polymorphism of the PPAR gamma 2 locus modulates the relationship between energy intake and body weight in type2 diabetic patients. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Triplet repeat instability correlates with dinucleotide instability in primary breast cancer. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The anandamide analogue, Met-F-AEA, controls human breast cancer cell migration via the RhoA/Rho kinase signaling pathway. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Rimonabant (SR141716) exerts anti-proliferative and immunomodulatory effects in human peripheral blood mononuclear cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Leptin induces mitogenic effect on human choriocarcinoma cell line (JAr) via MAP kinase activation in a glucose-dependent fashion. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Higher farnesyl diphosphate synthase activity in human colorectal cancer inhibition of cellular apoptosis. (Articolo in rivista) (Prodotto della ricerca)
- Cannabinoid receptor CB1 antagonists state of the art and challenges. (Articolo in rivista) (Prodotto della ricerca)
- A new role of anandamide in human sperm: focus on metabolism. (Articolo in rivista) (Prodotto della ricerca)
- Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions in the mouse colon (Articolo in rivista) (Prodotto della ricerca)
- PGC-1alpha down-regulation affects the antioxidant response in Friedreich's ataxia. (Articolo in rivista) (Prodotto della ricerca)
- Loss of the CBX7 protein expression correlates with a more aggressive phenotype in pancreatic cancer. (Articolo in rivista) (Prodotto della ricerca)
- Effects of anandamide on polyamine levels and cell growth in human colon cancer cells. (Articolo in rivista) (Prodotto della ricerca)
- Involvement of Akt/NF-ºB pathway in N6-isopentenyladenosine-induced apoptosis in human breast cancer cells. (Articolo in rivista) (Prodotto della ricerca)
- Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and of Ras farnesylation mediate antitumor effects of anandamide in human breast cancer cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Rimonabant (SR141716) induces metabolism and acquisition of fertilizing ability in human sperm. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Synergistic inhibition of human colon cancer cell growth by the cannabinoid CB1 receptor antagonist rimonabant and oxaliplatin. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Human sperm anatomy: ultrastructural localization of the cannabinoid1 receptor and a potential role of anandamide in sperm survival and acrosome reaction. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Prep1 controls insulin glucoregulatory function in liver by transcriptional targeting of SHP1 tyrosine phosphatase. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Increased levels of theAkt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Early and late events induced by polyq-expanded proteins: identification of a common pathogenic property of polyq-expanded proteins. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Interaction of endocannabinoid system and steroid hormones in the control of colon cancer cell growth. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Rimonabant reduces keratinocyte viability by induction of apoptosis and exerts topical anti-inflammatory activity in mice. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- PED/PEA-15 controls fibroblast motility and wound closure by ERK1/2-dependent mechanisms. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The plant hormone abscisic acid increases in human plasma after hyperglycemia and stimulates glucose consumption by adipocytes and myoblasts. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma (Articolo in rivista) (Prodotto della ricerca)
- HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway (Articolo in rivista) (Prodotto della ricerca)
- The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes. (Articolo in rivista) (Prodotto della ricerca)
- Involvement of protein kinase B and mitogen-activated protein kinases in experimental normothermic liver ischaemia-reperfusion injury. (Articolo in rivista) (Prodotto della ricerca)
- Alterations in protein tyrosine kinase pathways in rat liver following (Articolo in rivista) (Prodotto della ricerca)
- A novel mutation in SACS gene in a family from southern Italy (Articolo in rivista) (Prodotto della ricerca)
- Replication mediated instability of the GAA triplet repeat mutation in Friedreich ataxia (Articolo in rivista) (Prodotto della ricerca)
- Ataxia with oculomotor apraxia type 1 in Southern Italy: late onset and variable phenotype. (Articolo in rivista) (Prodotto della ricerca)
- PED/PEA-15 regulates glucose-induced insulin secretion by restraining potassium channel expression in pancreatic beta-cells. (Articolo in rivista) (Prodotto della ricerca)
- Molecular cloning and characterization of the human Ped/Pea-15 gene promoter reveals antagonistic regulation by HNF-4alpha and COUP-TFII. (Articolo in rivista) (Prodotto della ricerca)
- Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells. (Articolo in rivista) (Prodotto della ricerca)
- Glucose regulates diacylglycerol intracellular levels and protein kinase C activity by modulating diacylglycerol-kinase subcellular localization. (Articolo in rivista) (Prodotto della ricerca)
- Somatic instability of the expanded GAA triplet-repeat sequence in Friedreich ataxia progresses throughout life. (Articolo in rivista) (Prodotto della ricerca)
- Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines. (Articolo in rivista) (Prodotto della ricerca)
- Reply to the letter to the editor (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Iodine deficiency and goiter prevalence in a population living at sea level in Campania (Italy). (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Human Sperm Anatomy: Ultrastructural Localization of the Cannabinoid1 Receptor and a Potential Role of Anandamide in Sperm Survival and Acrosome Reaction. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- N6-isopentenyladenosine inhibits cell proliferation and induces apoptosis in a human colon cancer cell line DLD1. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Selective disruption of insulin-like growth factor (IGF)-1 signalling via phosphoinositide-dependent kinase-1 prevents the protective effect of IGF-1 on human cancer cell death. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Inverted duplication of 15q with terminal deletion in a multiple malformed newborn with intrauterine growth failure and lethal phenotype. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Selective disruption of insulin-like growth factor-1 (IGF-1) signaling via phosphoinositide-dependent kinase-1 prevents the protective effect of IGF-1 on human cancer cell death. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Preliminary data on effects of metformin on PED/PEA-15 cellular levels in obese women with polycystic ovary syndrome. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Rimonabant reduces keratinocyte viability by induction of apoptosis and exerts topical anti-inflammatory activity in mice. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Trischitta V, Frittitta L. ENPP1 Affects Insulin Action and Secretion: Evidences from In Vitro Studies. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Tyr phosphatase-mediated P-ERK inhibition suppresses senescence in EIA + v-raf transformed cells, which, paradoxically, are apoptosis-protected in a MEK-dependent manner. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- ER stress impairs MHC Class I surface expression and increases susceptibility of thyroid cells to NK-mediated cytotoxicity. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Genetic and pharmacologic inactivation of cannabinoid CB1 receptor inhibits angiogenesis. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- ENPP1 affects insulin action and secretion: evidences from in vitro studies. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The repressor element 1-silencing transcription factor is a novel molecular target for the neurotoxic effect of the polychlorinated biphenyl mixture aroclor 1254 in neuroblastoma SH-SY5Y cells. (Articolo in rivista) (Prodotto della ricerca)
- The CB1 receptor antagonist rimonabant controls cell viability and ascitic tumour growth in mice. (Articolo in rivista) (Prodotto della ricerca)
- Upregulation of miR-21 by Ras in vivo and its role in tumor growth. (Articolo in rivista) (Prodotto della ricerca)
- Cytotoxicity of dental resin composites: an in vitro evaluation. (Articolo in rivista) (Prodotto della ricerca)
- Signs of selective pressure on genetic variants affecting human height. (Articolo in rivista) (Prodotto della ricerca)
- Somatic instability in Friedreich ataxia occurs after organogenesis, progresses throughout life, and includes large, age-dependent expansions in dorsal root ganglia (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Peptide antagonists of the PED-hPLD1 binding (Articolo in rivista) (Prodotto della ricerca)
- Endocannabinoids as emergine suppressors of angiogenesis and tumor invasion (Articolo in rivista) (Prodotto della ricerca)
- Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Arvanil and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cells. (Articolo in rivista) (Prodotto della ricerca)
- Expression and purification of the D4 region of PLD1 and characterization of its interaction with PED-PEA15 (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Genome-wide scan for signatures of human population differentiation and their relationship with natural selection, functional pathways and diseases. (Articolo in rivista) (Prodotto della ricerca)
- A new strategy to block tumor growth by inhibiting endocannabinoid inactivation (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Association between Cannabinoid type-1 receptor polymorphism and body mass index in a Southern Italian population. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Antiangiogenetic activity of the endocannabinoid anandamide.Correlation to its tumour-suppressor efficacy (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Age-related impairment in insulin release: the essential role of ?(2)-adrenergic receptor. (Articolo in rivista) (Prodotto della ricerca)
- PED/PEA-15 induces autophagy and mediates TGF-beta1 effect on muscle cell differentiation. (Articolo in rivista) (Prodotto della ricerca)
- Cell fate following ER stress: just a matter of \"quo ante\" recovery or death? (Articolo in rivista) (Prodotto della ricerca)
- Adenoviral Gene Transfer of PLD1-D4 Enhances Insulin Sensitivity in Mice by Disrupting Phospholipase D1 Interaction with PED/PEA-15. (Articolo in rivista) (Prodotto della ricerca)
- Identification and functional characterization of a novel mutation in the NKX2-1 gene: comparison with the data in the literature. (Articolo in rivista) (Prodotto della ricerca)
- From anecdotal evidences of cannabinoids in multiple sclerosis to emerging new therapeutical approaches. (Articolo in rivista) (Prodotto della ricerca)
- Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells. (Articolo in rivista) (Prodotto della ricerca)
- Residues 762-801 of PLD1 mediate the interaction with PED/PEA15 (Articolo in rivista) (Prodotto della ricerca)
- Increased hexosamine biosynthetic pathway flux dedifferentiates INS-1E cells and murine islets by an extracellular signal-regulated kinase (ERK)1/2-mediated signal transmission pathway. (Articolo in rivista) (Prodotto della ricerca)
- Adipocyte-released insulin-like growth factor-1 is regulated by glucose and fatty acids and controls breast cancer cell growth in vitro. (Articolo in rivista) (Prodotto della ricerca)
- Inhibition of autophagy enhances the effects of E1A-defective oncolytic adenovirus dl922-947 against glioma cells in vitro and in vivo. (Articolo in rivista) (Prodotto della ricerca)
- Peroxisome proliferator-activated receptor-? activation enhances insulin-stimulated glucose disposal by reducing ped/pea-15 gene expression in skeletal muscle cells: evidence for involvement of activator protein-1. (Articolo in rivista) (Prodotto della ricerca)
- Bisphenol A in polycystic ovary syndrome and its association with liver-spleen axis. (Articolo in rivista) (Prodotto della ricerca)
- A functional allelic variant of the FGF23 gene is associated with renal phosphate leak in calcium nephrolithiasis. (Articolo in rivista) (Prodotto della ricerca)
- Anandamide inhibits the Wnt/?-catenin signalling pathway in human breast cancer MDA MB 231 cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Can Telomere Shortening in Human Peripheral Blood Leukocytes Serve as a Disease Biomarker of Friedreich's Ataxia? (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Measurement of glucose homeostasis in vivo: glucose and insulin tolerance tests. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- New expectations from the well-known medicinal properties of Arctium lappa. (Articolo in rivista) (Prodotto della ricerca)
- Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: an investigation of the 1,8-naphthyridin-2(1H)-one scaffold. (Articolo in rivista) (Prodotto della ricerca)
- Parental imprinting of rat insulin-like growth factor II gene promoters is coordinately regulated. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Inflammatory conditions associated to type 2 diabetes cause Prep-1 gene overexpression by inducing epigenetic modifications on its promoter region (Contributo in atti di convegno) (Prodotto della ricerca)
- CONDIZIONI INFIAMMATORIE ASSOCIATE AL DIABETE TIPO 2 ALTERANO LA REGOLAZIONE EPIGENETICA DEL GENE PREP1 (Contributo in atti di convegno) (Prodotto della ricerca)
- Hyperglycemia enhances the expression of the diabetogene ped/pea-15 through chromatin remodelling. (Contributo in atti di convegno) (Prodotto della ricerca)
- INSULIN REGULATES TYROSINE HYDROXYLASE EXPRESSION IN NEURONAL PC12 CELLS. (Contributo in atti di convegno) (Prodotto della ricerca)
- In adipocytes bisphenol-A down-regulates insulin sensitivity and up-regulates inflammatory pathways (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The Energy intake modulates the association of the -55CT polymorphism of UCP3 with body weight in type 2 diabetic patients. (Articolo in rivista) (Prodotto della ricerca)
- Lo stress del reticolo endoplasmatico (RE) indotto da glucosammina inibisce l'espressione del GLUT4 nelle cellule muscolari scheletriche mediante il fattore di attivazione della trascrizione (ATF) 6. (Articolo in rivista) (Prodotto della ricerca)
- Il fattore di trascrizione nucleare epatico HNF-4alpha è responsabile della repressione \"epigenetica\" del gene umano PED. (Altre pubblicazioni) (Prodotto della ricerca)
- Iperglicemia e acidi grassi alterano la regolazione epigenetica del gene Prep1 (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Identification of molecular pathways involved in diabetes-associated cancers. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- POLYCYSTIC OVARY SYNDROME AND HEPATIC STEATOSIS: COULD LOW-GRADE CHRONIC INFLAMMATION BE MEDIATED BY THE SPLEEN? (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- N6-isopentenyladenosine, an endogenous isoprenoid end product, directly affects cytotoxic and regulatory functions of human NK cells through FDPS modulation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Anandamide inhibits the Wnt/?-catenin signalling pathway in human breast cancer MDA MB 231 cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- GRP78 Mediates Cell Growth and Invasiveness in Endometrial Cancer. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 1,2-Dihydro-2-oxopyridine-3-carboxamides: The C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- A common response element mediates differential effects of phorbol esters and forskolin on type-1 plasminogen activator inhibitor gene expression in human breast carcinoma cells. (Articolo in rivista) (Prodotto della ricerca)
- lo stress del reticolo endoplasmatico (RE) indotto da glucosammina inibisce l'espressione del GLUT4 nelle cellule muscolari scheletriche mediante il fattore di attivazione della trscrizione (ATF) 6 (Altre pubblicazioni) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1717)
- FUNCTIONAL CHARACTERIZATION OF A NEW MUTATION IN THE NKX2.1 IN PATIENTS WITH \"THYROID-LUNG-BRAIN SYNDROME. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Hyperglycaemia enhances the expression of the diabetogene ped/pea-15 through chromatin remodelling. (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Shorter telomeres in patients with cerebral autosomal dominant arteriopathy and leukoencephalopathy (CADASIL) (Articolo in rivista) (Prodotto della ricerca)
- CpG islands under selective pressure are enriched with H3K4me3, H3K27ac and H3K36me3 histone modifications. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- N6-isopentenyladenosine improves nuclear shape in fibroblasts from humans with progeroid syndromes by inhibiting the farnesylation of prelamin A. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- CpG islands under selective pressure are enriched with H3K4me3, H3K27ac and H3K36me3 histone modifications. Akhtar MM, Scala G, Cocozza S, Miele G, Monticelli A. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Personalized medicine and type 2 diabetes: Lesson from epigenetics (Articolo in rivista) (Prodotto della ricerca)
- Antiangiogenic effects of N6-isopentenyladenosine, an endogenous isoprenoid end product, mediated by AMPK activation. (Articolo in rivista) (Prodotto della ricerca)
- Immune-Modulation and Properties of Absorption and Blood Brain Barrier Permeability of 1,8-Naphthyridine Derivatives. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- N6-isopentenyladenosine affects cytotoxic activity and cytokines production by IL-2 activated NK cells and exerts topical anti-inflammatory activity in mice (Articolo in rivista) (Prodotto della ricerca)
- Statins in neurological disorders: An overview and update (Articolo in rivista) (Prodotto della ricerca)
- Methylglyoxal impairs endothelial insulin sensitivity both in vitro and in vivo. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Evidence for evolutionary and nonevolutionary forces shaping the distribution of human genetic variants near transcription start sites (Articolo in rivista) (Prodotto della ricerca)
- PED/PEA-15 inhibits hydrogen peroxide-induced apoptosis in Ins-1E pancreatic beta-cells via PLD-1 (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Endoplasmic reticulum stress in endometrial cancer. (Articolo in rivista) (Prodotto della ricerca)
- The PPAR?2 Pro12Ala variant is protective against progression of nephropathy in people with type 2 diabetes (Articolo in rivista) (Prodotto della ricerca)
- Anandamide Drives Cell Cycle Progression through CB1 Receptors in a Rat Model of Synchronized Liver Regeneration. (Articolo in rivista) (Prodotto della ricerca)
- Understanding type 2 diabetes: from genetics to epigenetics (Articolo in rivista) (Prodotto della ricerca)
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