Modellistica molecolare di proteine legate a processi patologici (PM.P01.026.002)

Type

• Modulo (Classe)

Label

• Modellistica molecolare di proteine legate a processi patologici (PM.P01.026.002) (literal)

Prodotto

• Perturbation of the alpha/beta-dystroglycan interaction: consequences for skeletal muscle stability (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Alpha-Dystroglycan is a potential target of matrix metalloproteinase MMP-2 (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• La biologia computazionale e il suo ruolo nella ricerca biomedica: dalla modellistica di proteine al disegno di nuovi farmaci. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
• Il Distroglicano, un recettore coinvolto nelle distrofie muscolari: dalla biochimica cellulare ad un modello murino. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
• Neuroglobin expression and oxidant/antioxidant balance after graded traumatic brain injury in the rat (Articolo in rivista) (Prodotto della ricerca)
• Molecular interactions of a proline-rich peptide with the SH3 domain of tyrosine-protein kinase: a computational approach (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
• MicroRNAs in human blood leukocytes and coronary angioplasy (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
• A new monoclonal antibody DAG-6F4 against human alpha-dystroglycan reveals reduced core portein in some, but not all, dystroglycanopathy patients (Articolo in rivista) (Prodotto della ricerca)
• DAG1, no gene for RNA regulation? (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Docking studies and ligand recognition for allosteric modifiers of hemoglobin (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Computational model of the anthracycline-binding site in carbonyl and aldo-keto reductases: a structural basis for designing inhibitors (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Description of a new family and review of the literature (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Analysis at the molecular level of the interaction between alfa-dystroglycan and beta-dystroglycan (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Exploring protein folding and misfolding with molecular simulations (Comunicazione a convegno) (Prodotto della ricerca)
• The determinants of peptide aggregation: a molecular dynamics view (Comunicazione a convegno) (Prodotto della ricerca)
• The human keratoepithelin FAS1-4 domain as a model for the study of protein misfolding and amyloidogenesis: recombinant expression and preliminary characterisation (Abstract/Poster in convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1304)
• Role of the dystrophin-associated glycoprotein complex in limb-girdle and congenital muscular dystrophies: from molecular pathophysiology to potential therapy (Abstract/Poster in convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1304)
• Role of Methionine 35 in the intracellular Ca homeostasis Dysregulation and Ca-dependent Apoptosis induced by amyloid beta peptide in human Neuroblastoma IMR32 cells (Abstract/Poster in convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1304)
• Studying the features of real and virtual Cod Hb mutants by structural models (Comunicazione a convegno) (Prodotto della ricerca)
• dynamics simulations of wild type and mutant p53 “extreme C-terminus (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Immunological dissection of the human dystroglycan complex (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• The transmembrane collagen gliomedin interacts with perlecan, NrCAM and neurofascin at the nodes of Ranvier (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• IFN-gamma produced by human papilloma virus-18 E6-specific CD4(+) T cells predicts the clinical outcome after surgery in patients with high-grade cervical lesions (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Cib2 binds integrin alpha 7B beta 1D and is reduced in laminin alpha 2 chain-deficient muscular dystrophy (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• A Molecular Dynamics Study of the Interaction of D-Peptide Amyloid Inhibitors with Their Target Sequence Reveals a Potential Inhibitory Pharmacophore Conformation (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Molecular simulation of multistate peptide dynamics: A comparison between microsecond timescale sampling and multiple shorter trajectories (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Carcinoembryonic Antigen-Specific but Not Antiviral CD4(+) T Cell Immunity Is Impaired in Pancreatic Carcinoma Patients (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Structural basis for the interaction of isoDGR with the RGD-binding site of alpha v beta 3 integrin (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Altered expression of alpha-dystroglycan subunit in human gliomas (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Dystroglycan: a possible mediator for reducing congenital muscular dystrophy? (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Functional characterization of the single hemoglobin of the migratory bird Ciconia ciconia (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Modeling the interactions of T-cell receptor with MHCII bound to type II collagen peptide 261-273 (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
• Substitution of methionine 35 inhibits apoptotic effects of A beta(31-35) and A beta(25-35) fragments of amyloid-beta protein in PC12 cells (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Oxygen transport in amphibian: the functional properties of hemoglobins from “Bufo bufo” and “Bufo viridis” (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• An immunological analysis of dystroglycan subunits: lessons learned from a small cohort of non-congenital dystrophic patients. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Broad-Spectrum Inhibition of HIV-1 by a Monoclonal Antibody Directed against a gp120-Induced Epitope of CD4 (Articolo in rivista) (Prodotto della ricerca)
• Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker (Articolo in rivista) (Prodotto della ricerca)
• Structural analysis of a helical peptide unfolding pathway (Articolo in rivista) (Prodotto della ricerca)
• The structural intolerance of the PrP ±-fold for palar substitution of the helix-3 methionines (Articolo in rivista) (Prodotto della ricerca)
• Investigating Dynamic and Energetic Determinants of Protein Nucleic Acid Recognition: Analysis of the Zinc Finger Zif268-DNA Complexes (Articolo in rivista) (Prodotto della ricerca)
• Molecular interactions of hemoglobin with resveratrol: potential protective antioxidant role and metabolic adaptations of the erythrocyte (Articolo in rivista) (Prodotto della ricerca)
• New C-alkylcalix[4]resorcinarenes: a Computational Study (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
• Caffeine inhibits erythrocyte membrane derangement by antioxidant activity and by blocking caspase 3 activation (Articolo in rivista) (Prodotto della ricerca)
• PHOX2B regulates its own expression by a transcriptional auto-regulatory mechanism (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Protein kinase C-mediated phosphorylation of the BGT1 epithelial gamma-aminobutyric acid transporter regulates its association with LIN7 PDZ proteins - A post-translational mechanism regulating transporter surface density (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Localization of synaptic proteins involved in neurosecretion in different membrane microdomains. (Articolo in rivista) (Prodotto della ricerca)
• From the Arctic to the fetal life: physiological importance and computational studies of an “additional” chloride binding site in hemoglobin. Modelling Structure and Reactivity (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• NMR-based modelling and binding studies of a ternary complex between chicken liver bile acid binding protein and bile acids. (Articolo in rivista) (Prodotto della ricerca)
• First genetic analysis of lattice corneal dystrophy type I in a family from Bulgaria (Articolo in rivista) (Prodotto della ricerca)
• Understanding the binding of daunorubicin and doxorubicin to NADPH-dependent cytosolic reductases by computational methods (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Three dimensional structural model for human TCR-collagenII-MHC complex: protein-protein docking and molecular dynamics study (Abstract/Poster in convegno) (Prodotto della ricerca)
• Modeling the interactions of the anticancer agents daunorubicin and doxorubicin with the nadph-dependent cytosolic reductases: a structural basis for the design of less cardiotoxic anthracyclines (Abstract/Poster in convegno) (Prodotto della ricerca)
• Structure, function and molecular adaptations of haemoglobins of the polar cartilaginous fish Bathyraja eatonii and Raja hyperborea (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Mutational analysis at the alpha/beta dystroglycan interface. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• PRELIMINARY RESEARCH ON ERYTHROCYTE MEMBRANE DISORDERS IN NORMAL SUBJECTS AND ƒÒ THALASSEMIA CARRIERS (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• COD Hb alleles and environmental challenges: a correlation study (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Analysis of dystroglycan in human patients affected by neuromuscular disorders.Analysis of dystroglycan in human patients affected by neuromuscular disorders (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Structural and functional aspects of dystroglycan: towards the elucidation of its pathophysiological role (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Modeling and molecular dynamics of a-dystroglycan’s C-terminus reveals the presence of an Ig-like domain encompassing its b-dystroglycan binding epitope. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Role of the dystrophin-associated glycoprotein complex in limb-girdle and congenital muscular dystrophies: from molecular pathophysiology to potential therapy. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Analysis of the enzymatic activity of MMP-9 and MMP-2 on the recombinant domains of dystroglycan (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Is dystroglycan, a membrane receptor involved in muscular dystrophies, a target of the disulphide isomerase ERp57? (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Towards a reliable modeling approach for all dystroglycan domains (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Design of New Anticancer Agents (Contributo in volume (capitolo o saggio)) (Prodotto della ricerca)
• Molecular simulations of peptides: a useful tool for the development of new drugs and for the study of molecular recognition (Contributo in volume (capitolo o saggio)) (Prodotto della ricerca)
• Modeling the interactions of T-cell receptor with MHCII bound to type II collagen peptide (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• ±- and ²-dystroglycan: evaluation of processing and targeting through multiple fluorescent tagging (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Enzymatic processing by MMP-2 and MMP-9 of wild-type and mutated mouse ss-dystroglycan (Articolo in rivista) (Prodotto della ricerca)
• Inhibition of telomerase activity in HL-60 cell line by methacrylic monomers. (Contributo in volume (capitolo o saggio)) (Prodotto della ricerca)
• Dystroglycan's core protein revival: more on domain organization and function (Comunicazione a convegno) (Prodotto della ricerca)
• In silico screenig of new potential TCR/CollagenII-MHCII inhibitors against rheumatoid arthritis (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Assessing the role of the ±/²-dystroglycan interface for the processing and maturation of the dystroglycan precursor (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• MicroRnas involved in human peripheral blood leukocytes reaction to coronary angiography and angioplasty with drug eluting stent positioning (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• S100b protects IMR-32 cells against Ab(1-42) induced neurotoxicity via modulation of apoptotic genes expression (Articolo in rivista) (Prodotto della ricerca)
• New therapeutic targets in rheumatoid arthritis: selective inhibitors of recognition of TCR/MHCII-collagen complex. Drug (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• FRAP analysis of dystroglycan, a membrane receptor involved in congenital muscular dystrophies (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Insertion of a myc-tag within alpha-dystroglycan domains improves its biochemical and microscopic detection (Articolo in rivista) (Prodotto della ricerca)
• Dystroglycan is associated to the disulfide isomerase ERp57 (Articolo in rivista) (Prodotto della ricerca)
• Inibitori dell'interazione TCR/MHCII-Collagen interaction inhibitors useful for the treatment of rheumatoid arthritis (Brevetto) (Prodotto della ricerca)
• Structure-function studies of the polar cartilaginous fish Bathyraja eatonii and Raja hyperborea haemoglobins using homology modelling and molecular docking. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Cryptic nature of a conserved, CD4-inducible V3 loop neutralization epitope in the native envelope glycoprotein oligomer of CCR5-restricted, but not CXCR4-using, primary human immunodeficiency virus type 1 strains (Articolo in rivista) (Prodotto della ricerca)
• Functional and structural characterization of the myoglobin from the polychaete Ophelia bicornis (Articolo in rivista) (Prodotto della ricerca)
• Alzheimer's amyloid beta-peptide (1-42) induces cell death in human neuroblastoma via bax/bcl-2 ration increase: An intriguing role for methionine 35 (Articolo in rivista) (Prodotto della ricerca)
• Protective effect of rhubarb derivatives on amyloid beta (1-42) peptide-induced apoptosis in IMR-32 cells: A case of nutrigenomic (Articolo in rivista) (Prodotto della ricerca)
• Concerted mutation of Phe residues belonging to the beta-dystroglycan ectodomain strongly inhibits the interaction with alpha-dystroglycan in vitro (Articolo in rivista) (Prodotto della ricerca)
• Insights from molecular dynamics simulations: Structural basis for the V567D mutation-induced instability of zebrafish alpha-dystroglycan and comparison with the murine model (Articolo in rivista) (Prodotto della ricerca)
• The dystroglycan complex: From biology to cancer (Articolo in rivista) (Prodotto della ricerca)
• Ab(31-35) and Ab(25-35) fragments of amyloid beta-protein induce cellular death through apoptotic signals: Role of the redox state of methionine-35 (Articolo in rivista) (Prodotto della ricerca)
• Mechanism of helix nucleation and propagation: Microscopic view from microsecond time scale MD simulations (Articolo in rivista) (Prodotto della ricerca)
• A dynamic perspective on the molecular recognition of chitooligosaccharide ligands by hevein domains (Articolo in rivista) (Prodotto della ricerca)
• Cancer immunotherapy based on killing of Salmonella-infected tumor cells (Articolo in rivista) (Prodotto della ricerca)
• CD4(+) T cell immunity against the human papillomavirus-18 E6 transforming protein in healthy donors: identification of promiscuous naturally processed epitopes (Articolo in rivista) (Prodotto della ricerca)
• Genetic analysis of the dystroglycan gene in bronchopulmonary dysplasia affected premature newborns (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Amyloid-beta peptide affects the oxygen dependence of erythrocyte metabolism: A role for caspase 3 (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Alkaline Bohr effect of bird hemoglobins: the case of the flamingo (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Peptide self-assembly at the nanoscale: a challenging target for computational and experimental biotechnology (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Lymphocyte subset patterns and cytokine production in Alzheimer's disease patients (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Modeling enzymatic processes: A molecular simulation analysis of the origins of regioselectivity (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Spontaneous formation of L-isoaspartate and gain of function in fibronectin (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• The determinants of stability in the human prion protein: Insights into folding and misfolding from the analysis of the change in the stabilization energy distribution in different conditions (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• A folding inhibitor of the HIV-1 protease (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Mitochondrial oxygen consumption inhibition importance for TMT-dependent cell death in undifferentiated PC12 cells (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Combining computational and biochemical studies for a rationale on the anti-aromatase activity of natural polyphenols (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Relationship between energy distribution and fold stability: Insights from molecular dynamics simulations of native and mutant proteins (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Myelin basic protein-specific T lymphocytes proliferation and programmed cell death in demyelinating diseases (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• MAGE-A3(161-175) contains an HLA-DR beta 4 restricted natural epitope poorly formed through indirect presentation by dendritic cells (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• The role of cytosolic proteins in the insertion of tail-anchored proteins into phospholipid bilayers (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Probing the stability of the \"naked\" mucin-like domain of human alpha-dystroglycan (Articolo in rivista) (Prodotto della ricerca)
• Antiepileptic carbamazepine drug treatment induces alteration of membrane in red blood cells: Possible positive effects on metabolism and oxidative stress (Articolo in rivista) (Prodotto della ricerca)
• beta-amyloid decreases detectable endothelial nitric oxide synthase in human erythrocytes: a role for membrane acetylcholinesterase (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Increased levels of expression of dystroglycan may protect the heart (Articolo in rivista) (Prodotto della ricerca)
• The Multiple Affinities of alpha-Dystroglycan (Articolo in rivista) (Prodotto della ricerca)
• The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Critical role of flanking residues in NGR- to-iso DGR trasition and CD13/integrin receptor switching (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Characterization of a Monoclonal Antibody Specific for Novel Bcr/Abl Out-of-Frame Fusion Proteins (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Functional diversity of dystroglycan. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Liposome-mediated therapy of neuroblastoma (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Distribution of the pacemaker HCN4 channel mRNA and protein in the rabbit sinoatrial node (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Oxidation of methionine 35 reduces toxicity of the amyloid beta-peptide (1-42) in neuroblastoma cells (IMR-32) via enzyme methionine sulfoxide reductase A expression and function (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Protein folding simulations: combining coarse-grained models and all-atom molecular dynamics (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Naturally glycated hemoglobin: computational molecular model and functional studies (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
• Insight into a Novel p53 Single Point Mutation (G389E) by Molecular Dynamics Simulations (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• A second Ig-like domain identified in dystroglycan by molecular modelling and dynamics (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• A Gain-of-Glycosylation Mutation Associated with Myoclonus-Dystonia Syndrome Affects Trafficking and Processing of Mouse epsilon-Sarcoglycan in the Late Secretory Pathway (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Insertion of 16 Amino Acids in the BAR Domain of the Oligophrenin 1 Protein Causes Mental Retardation and Cerebellar Hypoplasia in an Italian Family (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Selective enzymatic synthesis of sitosterol glucoside acyl derivatives and evaluation of their cytotoxicity on human cancer cell lines (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Investigating the activation mechanism of Ser/Thr protein kinase Stkp from S. pneumoniae: insights from MD simulations (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
• The determinants of peptide aggregation: a molecular dynamics view (Comunicazione a convegno) (Prodotto della ricerca)
• Analisi strutturale e funzionale dei domini del distroglicano: ruolo per la stabilità del muscolo e aspetti fisiopatologici (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
• Analysis of dystroglycan in Teleost fishes (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Identification of amino acid sites involved in type I functional divergence in duplicated haemoglobin gene in Antarctic Notothenioid fishes (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Biochemical and cellular analysis of the dystroglycan alpha/beta interface (Comunicazione a convegno) (Prodotto della ricerca)
• Identification of the MMP-9 cleavage site on the recombinant b-dystroglycan ectodomain (Abstract/Poster in convegno) (Prodotto della ricerca)
• Evaluating the role of the dystroglycan alpha/beta interface in human muscular dystrophies (Abstract/Poster in convegno) (Prodotto della ricerca)
• Non-Redundant Role for IL-12 and IL-27 in Modulating Th2 Polarization of Carcinoembryonic Antigen Specific CD4 T Cells from Pancreatic Cancer Patients (Articolo in rivista) (Prodotto della ricerca)
• Amyloid-beta peptide(1-42) affects ATP release from human erythrocytes (Abstract/Poster in convegno) (Prodotto della ricerca)
• Modeling and molecular dynamics of alpha-dystroglycan's C-terminus reveals the presence of an Ig-like domain encompassing its beta-dystroglycan binding epitope (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
• Enzymatic Processing of beta-Dystroglycan Recombinant Ectodomain By MMP-9: Idendification of the Main Cleavage Site (Articolo in rivista) (Prodotto della ricerca)
• Ligands modulate the functional motion of Hsp90 by driving hte residue-residue interdomain communication: a molecular dynamics study (Abstract/Poster in convegno) (Prodotto della ricerca)
• Modeling the Ternary Complex TCR-Vbeta/Collagenll (261-273)/ HLA-DR4 Associated with Rheumatoid Arthritis (Articolo in rivista) (Prodotto della ricerca)
• A new beta-chain haemoglobin variant with increased oxygen affinity: Hb Roma [beta115(g17)Ala->Val] (Articolo in rivista) (Prodotto della ricerca)
• Changes in erythrocyte deformability in Alzheimer's disease: a role for nitric oxide synthase (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Analysis at the molecular level of the interaction between ±-dystroglycan and ²-dystroglycan and assessment of its implication for skeletal muscle physiopathology (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Identification of keratoepithelin in human skeletal muscle (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Oxygen binding in hemoglobins from Arctic and Antarctic species: structural basis of the low enthalpy change (Contributo in atti di convegno) (Prodotto della ricerca)
• Role of vasostatin-1 C-terminal region in fibroblast cell adhesion (Articolo in rivista) (Prodotto della ricerca)
• The ectodomain of beta-dystroglycan, a biomarker of cancer progression? (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• The P2Y-like receptor GPR17 as sensor of damage and a new potential target in spinal cord injury (Articolo in rivista) (Prodotto della ricerca)
• The cystatin structure: a case of non hierarchical protein folding (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Mutagenesis of the ±- and ²- dystroglycan interface (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Derangement of erythrocytic AE1 in beta-thalassemia by caspase 3: pathogenic mechanisms and implications in red blood cell senescence. (Articolo in rivista) (Prodotto della ricerca)
• Identification and characterization of folding inhibitors of hen egg lysozyme: An example of a new paradigm of drug design (Articolo in rivista) (Prodotto della ricerca)
• The Low-Affinity Receptor for Neurotrophins p75(NTR) Plays a Key Role for Satellite Cell Function in Muscle Repair Acting via RhoA (Articolo in rivista) (Prodotto della ricerca)
• Kinetics of Contact Formation and End-to-End Distance Distributions of Swollen Disordered Peptides (Articolo in rivista) (Prodotto della ricerca)
• Identification of an Agrin Mutation that Causes Congenital Myasthenia and Affects Synapse Function (Articolo in rivista) (Prodotto della ricerca)
• Mutagenesis at the alpha-beta interface impairs the cleavage of the dystroglycan precursor (Articolo in rivista) (Prodotto della ricerca)
• Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• HEMA intracellular concentrations and in vtiro cytotoxicity (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Modelling Signal Propagation Mechanisms and Ligand-Based Conformational Dynamics of the Hsp90 Molecular Chaperone Full Length Dimer (Comunicazione a convegno) (Prodotto della ricerca)
• Investigating and inhibiting peptide aggregation: what can simulations tell us? (Comunicazione a convegno) (Prodotto della ricerca)
• alpha-Dystroglycan, the usual suspect? (Articolo in rivista) (Prodotto della ricerca)
• Corneal deposit of ciprofloxacin after Laser Sub-Epithelial Keratomileusis (LASEK) procedure. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• O mannosylation of alpha-dystroglycan is essential for lymphocytic choriomeningitis virus receptor function (Articolo in rivista) (Prodotto della ricerca)
• Modeling TCR-p/MHC interactions associated with rheumatoid arthritis (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
• Combined in silico and experimental approach for drug design: the binding mode of peptidic and non-peptidic inhibitors to hsp90 N-terminal domain. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• MicroRNA from human peripheral blood leukocytes and cardiovascular diseases (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
• alpha-Dystroglycan does not play a major pathogenic role in autosomal recessive hereditary inclusion-body myopathy (Articolo in rivista) (Prodotto della ricerca)
• Assessing the influence of electrostatic schemes on molecular dynamics simulations of secondary structure forming peptides (Articolo in rivista) (Prodotto della ricerca)
• Activation of muscle-specific receptor tyrosine kinase and binding to dystroglycan are regulated by alternative mRNA splicing of agrin (Articolo in rivista) (Prodotto della ricerca)
• Antileukemic activity of shepherdin and molecular diversity of Hsp90 inhibitors (Articolo in rivista) (Prodotto della ricerca)
• Long-lasting CCR5 internalization by antibodies in a subset of long-term nonprogressors: a possible protective effect against disease progression (Articolo in rivista) (Prodotto della ricerca)
• Identification of novel subdominant epitopes on the carcinoembryonic antigen recognized by CD4(+) T cells of lung cancer patients (Articolo in rivista) (Prodotto della ricerca)
• Amyloid-beta peptide induces Caspase 3 Activation and Metabolic Alterations in human Erythrocytes (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
• Targeting liposomal chemotherapy via both tumor cell-specific and tumor vasculature-specific ligands potentiates therapeutic efficacy (Articolo in rivista) (Prodotto della ricerca)
• Protective effects of stilbenes molecules against Beta-Amyloid-induced mitochondria dysfunctions in IMR-32 cells (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
• Critical role of the N-loop and beta 1-strand hydrophobic clusters of RANTES-derived peptides in anti-HIV activity (Articolo in rivista) (Prodotto della ricerca)
• Modelling Signal Propagation Mechanisms and Ligand-Based Conformational Dynamics of the Hsp90 Molecular Chaperone Full Length Dimer (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
• A beta(31-35) peptide induce apoptosis in PC 12 cells: Contrast with A beta(25-35) peptide and examination of underlying mechanisms (Articolo in rivista) (Prodotto della ricerca)
• Sequence dependence of amyloid fibril formation: Insights from molecular dynamics simulations (Articolo in rivista) (Prodotto della ricerca)
• Hepatitis C virus-specific reactivity of CD4+-lymphocytes in children born from HCV-infected women (Articolo in rivista) (Prodotto della ricerca)
• Membrane assisted coupled enzyme system for phospholipid modification (Articolo in rivista) (Prodotto della ricerca)
• Decrease and dysfunction of dendritic cells correlate with impaired hepatitis C virus-specific CD4(+) T-cell proliferation in patients with hepatitis C virus infection (Articolo in rivista) (Prodotto della ricerca)
• Transcription factor PHOX2A regulates the human alpha 3 nicotinic receptor subunit gene promoter (Articolo in rivista) (Prodotto della ricerca)
• Hb Santa Clara (beta 97His -> Asn), a human haemoglobin variant: Functional characterization and structure modelling (Articolo in rivista) (Prodotto della ricerca)
• Similar folds with different stabilization mechanisms: the cases of prion and doppel proteins (Articolo in rivista) (Prodotto della ricerca)
• Marimpietri D, Pagnan G, Cilli M, Lepekhin EA, Garde SV, Longhi R, Corti A, Allen TM, Wu JJ, Ponzoni M Enhanced Antitumor Efficacy of Clinical-Grade Vasculature-Targeted Liposomal Doxorubicin (Articolo in rivista) (Prodotto della ricerca)
• CD4+CD25+FoxP3+PD1 - regulatory T cells in acute and stable relapsing-remitting multiple sclerosis and their modulation by therapy (Articolo in rivista) (Prodotto della ricerca)
• Isoaspartate-glycine-arginine: A new tumor vasculature-targeting motif (Articolo in rivista) (Prodotto della ricerca)
• Endosomal proteases influence the repertoire of MAGE-A3 epitopes recognized in vivo by CD4(+) T cells (Articolo in rivista) (Prodotto della ricerca)
• Pixantrone (BBR2778) reduces the severity of experimental autoimmune myasthenia gravis in lewis rats (Articolo in rivista) (Prodotto della ricerca)
• Fibroblast apoptosis in a patient affected by lamellar ichthyosis (Articolo in rivista) (Prodotto della ricerca)
• MAGE-A3(161-175) contains an HLA-DR beta 4 restricted natural epitope poorly formed through indirect presentation by dendritic cells (Articolo in rivista) (Prodotto della ricerca)
• Duplication of the dystroglycan gene in most branches of teleost fish (Articolo in rivista) (Prodotto della ricerca)
• Evaluating the role of the dystroglycan alpha/beta interface in human muscular dystrophies (Articolo in rivista) (Prodotto della ricerca)
• Expression of multiple AQP4 pools in the plasma membrane and their association with the dystrophin complex (Articolo in rivista) (Prodotto della ricerca)
• Mutazione di splicing nel gene OPHN1 determina la produzione di tre trascritti alternativi ed altrettante isoforme proteiche non funzionanti (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• First molecular characterization and immunolocalization of keratoepithelin in adult human skeletal muscle (Articolo in rivista) (Prodotto della ricerca)
• Alpha Dystroglycan monoclonal antibodies (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
• Immunostaining of the sarcolemma with a new monoclonal antibody against alpha-dystroglycan core and its relevance to diagnosis (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
• Folding and mis-folding of peptides and proteins: Insights from molecular simulations (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Caffeine inhibits erythrocyte membrane derangement by antioxidant activity and blocking caspase 3 activation (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Investigation and inhibiting peptide aggregation: what can simulations tell us? (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
• Fragment 31-35 of beta-amyloid peptide induces neurodegeneration in rat cerebellar granule cells via bax gene expression and caspase-3 activation - A crucial role for the redox state of methionine-35 residue (Articolo in rivista) (Prodotto della ricerca)
• Immunogenic and structural properties of the Asn-Gly-Arg (NGR) tumor neovasculature-homing motif (Articolo in rivista) (Prodotto della ricerca)
• Small-molecule targeting of heat shock protein 90 chaperone function: Rational identification of a new anticancer lead (Articolo in rivista) (Prodotto della ricerca)
• Programmed cell death and expression of apoptotic genes in PBMC from multiple sclerosis patients (Articolo in rivista) (Prodotto della ricerca)
• The hemocyanin of the shamefaced crab Calappa granulata: Structural-functional characterization (Articolo in rivista) (Prodotto della ricerca)
• Effect of hexafluoroisopropanol alcohol on the structure of melittin: A molecular dynamics simulation study (Articolo in rivista) (Prodotto della ricerca)
• Structure elucidation and 3D solution conformation of the antibiotic enduracidin determined by NMR spectroscopy and molecular dynamics (Articolo in rivista) (Prodotto della ricerca)
• Molecular dynamics simulation of the aggregation of the core-recognition motif of the islet amylolid polypeptide in explicit water (Articolo in rivista) (Prodotto della ricerca)
• Study of the villin headpiece folding dynamics by combining coarse-grained Monte Carlo evolution and all-atom molecular dynamics (Articolo in rivista) (Prodotto della ricerca)
• Induction of murine mucosal CCR5-reactive antibodies as an anti-human immunodeficiency virus strategy (Articolo in rivista) (Prodotto della ricerca)
• Decrease in pathology and progression of scrapie after immunisation with synthetic prion protein peptides in hamsters (Articolo in rivista) (Prodotto della ricerca)
• N-myristoylation determines dual targeting of mammalian NADH-cytochrome b(5) reductase to ER and mitochondrial outer membranes by a mechanism of kinetic partitioning (Articolo in rivista) (Prodotto della ricerca)
• Enzyme Reactivity Studied by Computer Simulations (Contributo in volume (capitolo o saggio)) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1201)
• Immunodetection of partially glycosylated isoforms of alpha-dystroglycan by a new monoclonal antibody against its beta-dystroglycan-binding epitope (Articolo in rivista) (Prodotto della ricerca)
• Nuovi target terapeutici per le malattie autoimmuni: ricerca di inibitori selettivi del complesso TCR/MHCII-peptidev (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
• Structural and functional characteristics of a basic salivary proline-rich peptide (Abstract/Poster in atti di convegno) (Prodotto della ricerca)

Codice

• PM.P01.026.002 (literal)

Anno di chiusura previsto

• 2015-01-01T00:00:00+01:00 (literal)

Istituto esecutore

• Istituto di chimica del riconoscimento molecolare (ICRM) (Istituto)

Primo anno di attività

• 2005-01-01T00:00:00+01:00 (literal)

Abstract

• Lo studio delle cause molecolari di importanti patologie cronico-degenerative, neurodegenerative, cardiovascolari, metaboliche e tumorali rappresenta uno degli aspetti fondamentali della medicina nell'era post-genomica. Nella maggior parte dei casi, nella genesi di queste patologie sono coinvolte proteine mutate o ripiegate in una struttura 3D non corretta (non-nativa). Lo studio delle correlazioni sequenza-struttura-dimamica-funzione delle proteine coinvolte può fornire informazioni fondamentali per per identificare nuovi approcci terapeutici per il trattamento delle patologie. In questo contesto, i nostri studi si propongono di utilizzare un approccio interdisciplinare per la definizione dei determinanti molecolari sopra descritti utilizzando studi funzionali, strutturali e computazionali di biomolecole, per ottenere una visione a risoluzione atomica dei processi coinvolti e progettare razionalmente a livello molecolare nuovi approcci terapeutici. I risultati ottenuti fino a questo momento hanno provato la validità dell'approccio. (literal)

Nome

• Modellistica molecolare di proteine legate a processi patologici (literal)

Descrizione

• Descrizione del modulo "Modellistica molecolare di proteine legate a processi patologici (PM.P01.026.002)" (Descrizione modulo)
• Descrizione collaborazioni del modulo "Modellistica molecolare di proteine legate a processi patologici (PM.P01.026.002)" (Descrizione collaborazioni)
• Descrizione dello stato di avanzamento delle attività del modulo "Modellistica molecolare di proteine legate a processi patologici (PM.P01.026.002)" (Descrizione stato avanzamento attività)

Modulo di

• Strutturistica NMR e modellistica molecolare di proteine legate a processi patologici (PM.P01.026) (Commessa)

Gestore

• MARIA CRISTINA DE ROSA (Persona)

Incoming links:

Prodotto di

• Amyloid-beta peptide induces Caspase 3 Activation and Metabolic Alterations in human Erythrocytes (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
• Protective effects of stilbenes molecules against Beta-Amyloid-induced mitochondria dysfunctions in IMR-32 cells (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
• Modelling Signal Propagation Mechanisms and Ligand-Based Conformational Dynamics of the Hsp90 Molecular Chaperone Full Length Dimer (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
• Investigation and inhibiting peptide aggregation: what can simulations tell us? (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
• The dystroglycan complex: From biology to cancer (Articolo in rivista) (Prodotto della ricerca)
• Ab(31-35) and Ab(25-35) fragments of amyloid beta-protein induce cellular death through apoptotic signals: Role of the redox state of methionine-35 (Articolo in rivista) (Prodotto della ricerca)
• Mechanism of helix nucleation and propagation: Microscopic view from microsecond time scale MD simulations (Articolo in rivista) (Prodotto della ricerca)
• A dynamic perspective on the molecular recognition of chitooligosaccharide ligands by hevein domains (Articolo in rivista) (Prodotto della ricerca)
• Cancer immunotherapy based on killing of Salmonella-infected tumor cells (Articolo in rivista) (Prodotto della ricerca)
• CD4(+) T cell immunity against the human papillomavirus-18 E6 transforming protein in healthy donors: identification of promiscuous naturally processed epitopes (Articolo in rivista) (Prodotto della ricerca)
• Cryptic nature of a conserved, CD4-inducible V3 loop neutralization epitope in the native envelope glycoprotein oligomer of CCR5-restricted, but not CXCR4-using, primary human immunodeficiency virus type 1 strains (Articolo in rivista) (Prodotto della ricerca)
• Functional and structural characterization of the myoglobin from the polychaete Ophelia bicornis (Articolo in rivista) (Prodotto della ricerca)
• Alzheimer's amyloid beta-peptide (1-42) induces cell death in human neuroblastoma via bax/bcl-2 ration increase: An intriguing role for methionine 35 (Articolo in rivista) (Prodotto della ricerca)
• Protective effect of rhubarb derivatives on amyloid beta (1-42) peptide-induced apoptosis in IMR-32 cells: A case of nutrigenomic (Articolo in rivista) (Prodotto della ricerca)
• Concerted mutation of Phe residues belonging to the beta-dystroglycan ectodomain strongly inhibits the interaction with alpha-dystroglycan in vitro (Articolo in rivista) (Prodotto della ricerca)
• Modeling enzymatic processes: A molecular simulation analysis of the origins of regioselectivity (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Spontaneous formation of L-isoaspartate and gain of function in fibronectin (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• The determinants of stability in the human prion protein: Insights into folding and misfolding from the analysis of the change in the stabilization energy distribution in different conditions (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• A folding inhibitor of the HIV-1 protease (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Genetic analysis of the dystroglycan gene in bronchopulmonary dysplasia affected premature newborns (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Amyloid-beta peptide affects the oxygen dependence of erythrocyte metabolism: A role for caspase 3 (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Alkaline Bohr effect of bird hemoglobins: the case of the flamingo (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Peptide self-assembly at the nanoscale: a challenging target for computational and experimental biotechnology (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Lymphocyte subset patterns and cytokine production in Alzheimer's disease patients (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Combining computational and biochemical studies for a rationale on the anti-aromatase activity of natural polyphenols (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Relationship between energy distribution and fold stability: Insights from molecular dynamics simulations of native and mutant proteins (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Myelin basic protein-specific T lymphocytes proliferation and programmed cell death in demyelinating diseases (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• MAGE-A3(161-175) contains an HLA-DR beta 4 restricted natural epitope poorly formed through indirect presentation by dendritic cells (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Mitochondrial oxygen consumption inhibition importance for TMT-dependent cell death in undifferentiated PC12 cells (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Derangement of erythrocytic AE1 in beta-thalassemia by caspase 3: pathogenic mechanisms and implications in red blood cell senescence. (Articolo in rivista) (Prodotto della ricerca)
• Identification and characterization of folding inhibitors of hen egg lysozyme: An example of a new paradigm of drug design (Articolo in rivista) (Prodotto della ricerca)
• The Low-Affinity Receptor for Neurotrophins p75(NTR) Plays a Key Role for Satellite Cell Function in Muscle Repair Acting via RhoA (Articolo in rivista) (Prodotto della ricerca)
• Kinetics of Contact Formation and End-to-End Distance Distributions of Swollen Disordered Peptides (Articolo in rivista) (Prodotto della ricerca)
• Identification of an Agrin Mutation that Causes Congenital Myasthenia and Affects Synapse Function (Articolo in rivista) (Prodotto della ricerca)
• Mutagenesis at the alpha-beta interface impairs the cleavage of the dystroglycan precursor (Articolo in rivista) (Prodotto della ricerca)
• Non-Redundant Role for IL-12 and IL-27 in Modulating Th2 Polarization of Carcinoembryonic Antigen Specific CD4 T Cells from Pancreatic Cancer Patients (Articolo in rivista) (Prodotto della ricerca)
• Enzymatic Processing of beta-Dystroglycan Recombinant Ectodomain By MMP-9: Idendification of the Main Cleavage Site (Articolo in rivista) (Prodotto della ricerca)
• Modeling the Ternary Complex TCR-Vbeta/Collagenll (261-273)/ HLA-DR4 Associated with Rheumatoid Arthritis (Articolo in rivista) (Prodotto della ricerca)
• A new beta-chain haemoglobin variant with increased oxygen affinity: Hb Roma [beta115(g17)Ala->Val] (Articolo in rivista) (Prodotto della ricerca)
• Role of vasostatin-1 C-terminal region in fibroblast cell adhesion (Articolo in rivista) (Prodotto della ricerca)
• The P2Y-like receptor GPR17 as sensor of damage and a new potential target in spinal cord injury (Articolo in rivista) (Prodotto della ricerca)
• alpha-Dystroglycan, the usual suspect? (Articolo in rivista) (Prodotto della ricerca)
• O mannosylation of alpha-dystroglycan is essential for lymphocytic choriomeningitis virus receptor function (Articolo in rivista) (Prodotto della ricerca)
• A beta(31-35) peptide induce apoptosis in PC 12 cells: Contrast with A beta(25-35) peptide and examination of underlying mechanisms (Articolo in rivista) (Prodotto della ricerca)
• Sequence dependence of amyloid fibril formation: Insights from molecular dynamics simulations (Articolo in rivista) (Prodotto della ricerca)
• Hepatitis C virus-specific reactivity of CD4+-lymphocytes in children born from HCV-infected women (Articolo in rivista) (Prodotto della ricerca)
• Membrane assisted coupled enzyme system for phospholipid modification (Articolo in rivista) (Prodotto della ricerca)
• alpha-Dystroglycan does not play a major pathogenic role in autosomal recessive hereditary inclusion-body myopathy (Articolo in rivista) (Prodotto della ricerca)
• Assessing the influence of electrostatic schemes on molecular dynamics simulations of secondary structure forming peptides (Articolo in rivista) (Prodotto della ricerca)
• Activation of muscle-specific receptor tyrosine kinase and binding to dystroglycan are regulated by alternative mRNA splicing of agrin (Articolo in rivista) (Prodotto della ricerca)
• Antileukemic activity of shepherdin and molecular diversity of Hsp90 inhibitors (Articolo in rivista) (Prodotto della ricerca)
• Long-lasting CCR5 internalization by antibodies in a subset of long-term nonprogressors: a possible protective effect against disease progression (Articolo in rivista) (Prodotto della ricerca)
• Identification of novel subdominant epitopes on the carcinoembryonic antigen recognized by CD4(+) T cells of lung cancer patients (Articolo in rivista) (Prodotto della ricerca)
• Targeting liposomal chemotherapy via both tumor cell-specific and tumor vasculature-specific ligands potentiates therapeutic efficacy (Articolo in rivista) (Prodotto della ricerca)
• Critical role of the N-loop and beta 1-strand hydrophobic clusters of RANTES-derived peptides in anti-HIV activity (Articolo in rivista) (Prodotto della ricerca)
• Similar folds with different stabilization mechanisms: the cases of prion and doppel proteins (Articolo in rivista) (Prodotto della ricerca)
• Decrease and dysfunction of dendritic cells correlate with impaired hepatitis C virus-specific CD4(+) T-cell proliferation in patients with hepatitis C virus infection (Articolo in rivista) (Prodotto della ricerca)
• Transcription factor PHOX2A regulates the human alpha 3 nicotinic receptor subunit gene promoter (Articolo in rivista) (Prodotto della ricerca)
• Hb Santa Clara (beta 97His -> Asn), a human haemoglobin variant: Functional characterization and structure modelling (Articolo in rivista) (Prodotto della ricerca)
• MAGE-A3(161-175) contains an HLA-DR beta 4 restricted natural epitope poorly formed through indirect presentation by dendritic cells (Articolo in rivista) (Prodotto della ricerca)
• Duplication of the dystroglycan gene in most branches of teleost fish (Articolo in rivista) (Prodotto della ricerca)
• Evaluating the role of the dystroglycan alpha/beta interface in human muscular dystrophies (Articolo in rivista) (Prodotto della ricerca)
• Expression of multiple AQP4 pools in the plasma membrane and their association with the dystrophin complex (Articolo in rivista) (Prodotto della ricerca)
• First molecular characterization and immunolocalization of keratoepithelin in adult human skeletal muscle (Articolo in rivista) (Prodotto della ricerca)
• Marimpietri D, Pagnan G, Cilli M, Lepekhin EA, Garde SV, Longhi R, Corti A, Allen TM, Wu JJ, Ponzoni M Enhanced Antitumor Efficacy of Clinical-Grade Vasculature-Targeted Liposomal Doxorubicin (Articolo in rivista) (Prodotto della ricerca)
• CD4+CD25+FoxP3+PD1 - regulatory T cells in acute and stable relapsing-remitting multiple sclerosis and their modulation by therapy (Articolo in rivista) (Prodotto della ricerca)
• Isoaspartate-glycine-arginine: A new tumor vasculature-targeting motif (Articolo in rivista) (Prodotto della ricerca)
• Endosomal proteases influence the repertoire of MAGE-A3 epitopes recognized in vivo by CD4(+) T cells (Articolo in rivista) (Prodotto della ricerca)
• Pixantrone (BBR2778) reduces the severity of experimental autoimmune myasthenia gravis in lewis rats (Articolo in rivista) (Prodotto della ricerca)
• Fibroblast apoptosis in a patient affected by lamellar ichthyosis (Articolo in rivista) (Prodotto della ricerca)
• Functional diversity of dystroglycan. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Liposome-mediated therapy of neuroblastoma (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Distribution of the pacemaker HCN4 channel mRNA and protein in the rabbit sinoatrial node (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Oxidation of methionine 35 reduces toxicity of the amyloid beta-peptide (1-42) in neuroblastoma cells (IMR-32) via enzyme methionine sulfoxide reductase A expression and function (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Critical role of flanking residues in NGR- to-iso DGR trasition and CD13/integrin receptor switching (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Characterization of a Monoclonal Antibody Specific for Novel Bcr/Abl Out-of-Frame Fusion Proteins (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Insight into a Novel p53 Single Point Mutation (G389E) by Molecular Dynamics Simulations (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• A second Ig-like domain identified in dystroglycan by molecular modelling and dynamics (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• A Gain-of-Glycosylation Mutation Associated with Myoclonus-Dystonia Syndrome Affects Trafficking and Processing of Mouse epsilon-Sarcoglycan in the Late Secretory Pathway (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Insertion of 16 Amino Acids in the BAR Domain of the Oligophrenin 1 Protein Causes Mental Retardation and Cerebellar Hypoplasia in an Italian Family (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Effect of hexafluoroisopropanol alcohol on the structure of melittin: A molecular dynamics simulation study (Articolo in rivista) (Prodotto della ricerca)
• Structure elucidation and 3D solution conformation of the antibiotic enduracidin determined by NMR spectroscopy and molecular dynamics (Articolo in rivista) (Prodotto della ricerca)
• Molecular dynamics simulation of the aggregation of the core-recognition motif of the islet amylolid polypeptide in explicit water (Articolo in rivista) (Prodotto della ricerca)
• Study of the villin headpiece folding dynamics by combining coarse-grained Monte Carlo evolution and all-atom molecular dynamics (Articolo in rivista) (Prodotto della ricerca)
• Induction of murine mucosal CCR5-reactive antibodies as an anti-human immunodeficiency virus strategy (Articolo in rivista) (Prodotto della ricerca)
• Decrease in pathology and progression of scrapie after immunisation with synthetic prion protein peptides in hamsters (Articolo in rivista) (Prodotto della ricerca)
• N-myristoylation determines dual targeting of mammalian NADH-cytochrome b(5) reductase to ER and mitochondrial outer membranes by a mechanism of kinetic partitioning (Articolo in rivista) (Prodotto della ricerca)
• Immunodetection of partially glycosylated isoforms of alpha-dystroglycan by a new monoclonal antibody against its beta-dystroglycan-binding epitope (Articolo in rivista) (Prodotto della ricerca)
• Fragment 31-35 of beta-amyloid peptide induces neurodegeneration in rat cerebellar granule cells via bax gene expression and caspase-3 activation - A crucial role for the redox state of methionine-35 residue (Articolo in rivista) (Prodotto della ricerca)
• Immunogenic and structural properties of the Asn-Gly-Arg (NGR) tumor neovasculature-homing motif (Articolo in rivista) (Prodotto della ricerca)
• Small-molecule targeting of heat shock protein 90 chaperone function: Rational identification of a new anticancer lead (Articolo in rivista) (Prodotto della ricerca)
• Programmed cell death and expression of apoptotic genes in PBMC from multiple sclerosis patients (Articolo in rivista) (Prodotto della ricerca)
• The hemocyanin of the shamefaced crab Calappa granulata: Structural-functional characterization (Articolo in rivista) (Prodotto della ricerca)
• Altered expression of alpha-dystroglycan subunit in human gliomas (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Dystroglycan: a possible mediator for reducing congenital muscular dystrophy? (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Functional characterization of the single hemoglobin of the migratory bird Ciconia ciconia (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• IFN-gamma produced by human papilloma virus-18 E6-specific CD4(+) T cells predicts the clinical outcome after surgery in patients with high-grade cervical lesions (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Cib2 binds integrin alpha 7B beta 1D and is reduced in laminin alpha 2 chain-deficient muscular dystrophy (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• A Molecular Dynamics Study of the Interaction of D-Peptide Amyloid Inhibitors with Their Target Sequence Reveals a Potential Inhibitory Pharmacophore Conformation (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Molecular simulation of multistate peptide dynamics: A comparison between microsecond timescale sampling and multiple shorter trajectories (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Carcinoembryonic Antigen-Specific but Not Antiviral CD4(+) T Cell Immunity Is Impaired in Pancreatic Carcinoma Patients (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Structural basis for the interaction of isoDGR with the RGD-binding site of alpha v beta 3 integrin (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker (Articolo in rivista) (Prodotto della ricerca)
• Structural analysis of a helical peptide unfolding pathway (Articolo in rivista) (Prodotto della ricerca)
• The structural intolerance of the PrP ±-fold for palar substitution of the helix-3 methionines (Articolo in rivista) (Prodotto della ricerca)
• Investigating Dynamic and Energetic Determinants of Protein Nucleic Acid Recognition: Analysis of the Zinc Finger Zif268-DNA Complexes (Articolo in rivista) (Prodotto della ricerca)
• Broad-Spectrum Inhibition of HIV-1 by a Monoclonal Antibody Directed against a gp120-Induced Epitope of CD4 (Articolo in rivista) (Prodotto della ricerca)
• Caffeine inhibits erythrocyte membrane derangement by antioxidant activity and by blocking caspase 3 activation (Articolo in rivista) (Prodotto della ricerca)
• First genetic analysis of lattice corneal dystrophy type I in a family from Bulgaria (Articolo in rivista) (Prodotto della ricerca)
• Substitution of methionine 35 inhibits apoptotic effects of A beta(31-35) and A beta(25-35) fragments of amyloid-beta protein in PC12 cells (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Oxygen transport in amphibian: the functional properties of hemoglobins from “Bufo bufo” and “Bufo viridis” (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• An immunological analysis of dystroglycan subunits: lessons learned from a small cohort of non-congenital dystrophic patients. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Folding and mis-folding of peptides and proteins: Insights from molecular simulations (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Description of a new family and review of the literature (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Analysis at the molecular level of the interaction between alfa-dystroglycan and beta-dystroglycan (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Exploring protein folding and misfolding with molecular simulations (Comunicazione a convegno) (Prodotto della ricerca)
• The determinants of peptide aggregation: a molecular dynamics view (Comunicazione a convegno) (Prodotto della ricerca)
• Docking studies and ligand recognition for allosteric modifiers of hemoglobin (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Computational model of the anthracycline-binding site in carbonyl and aldo-keto reductases: a structural basis for designing inhibitors (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Studying the features of real and virtual Cod Hb mutants by structural models (Comunicazione a convegno) (Prodotto della ricerca)
• dynamics simulations of wild type and mutant p53 “extreme C-terminus (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Immunological dissection of the human dystroglycan complex (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• The transmembrane collagen gliomedin interacts with perlecan, NrCAM and neurofascin at the nodes of Ranvier (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• The human keratoepithelin FAS1-4 domain as a model for the study of protein misfolding and amyloidogenesis: recombinant expression and preliminary characterisation (Abstract/Poster in convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1304)
• Role of the dystrophin-associated glycoprotein complex in limb-girdle and congenital muscular dystrophies: from molecular pathophysiology to potential therapy (Abstract/Poster in convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1304)
• Role of Methionine 35 in the intracellular Ca homeostasis Dysregulation and Ca-dependent Apoptosis induced by amyloid beta peptide in human Neuroblastoma IMR32 cells (Abstract/Poster in convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1304)
• Modeling the interactions of T-cell receptor with MHCII bound to type II collagen peptide (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• ±- and ²-dystroglycan: evaluation of processing and targeting through multiple fluorescent tagging (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Structural and functional aspects of dystroglycan: towards the elucidation of its pathophysiological role (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Modeling and molecular dynamics of a-dystroglycan’s C-terminus reveals the presence of an Ig-like domain encompassing its b-dystroglycan binding epitope. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Role of the dystrophin-associated glycoprotein complex in limb-girdle and congenital muscular dystrophies: from molecular pathophysiology to potential therapy. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Is dystroglycan, a membrane receptor involved in muscular dystrophies, a target of the disulphide isomerase ERp57? (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Dystroglycan's core protein revival: more on domain organization and function (Comunicazione a convegno) (Prodotto della ricerca)
• In silico screenig of new potential TCR/CollagenII-MHCII inhibitors against rheumatoid arthritis (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Assessing the role of the ±/²-dystroglycan interface for the processing and maturation of the dystroglycan precursor (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• MicroRnas involved in human peripheral blood leukocytes reaction to coronary angiography and angioplasty with drug eluting stent positioning (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• From the Arctic to the fetal life: physiological importance and computational studies of an “additional” chloride binding site in hemoglobin. Modelling Structure and Reactivity (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Mutational analysis at the alpha/beta dystroglycan interface. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• PRELIMINARY RESEARCH ON ERYTHROCYTE MEMBRANE DISORDERS IN NORMAL SUBJECTS AND ƒÒ THALASSEMIA CARRIERS (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• COD Hb alleles and environmental challenges: a correlation study (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Analysis of dystroglycan in human patients affected by neuromuscular disorders.Analysis of dystroglycan in human patients affected by neuromuscular disorders (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Three dimensional structural model for human TCR-collagenII-MHC complex: protein-protein docking and molecular dynamics study (Abstract/Poster in convegno) (Prodotto della ricerca)
• Modeling the interactions of the anticancer agents daunorubicin and doxorubicin with the nadph-dependent cytosolic reductases: a structural basis for the design of less cardiotoxic anthracyclines (Abstract/Poster in convegno) (Prodotto della ricerca)
• Analysis of the enzymatic activity of MMP-9 and MMP-2 on the recombinant domains of dystroglycan (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Towards a reliable modeling approach for all dystroglycan domains (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Identification of amino acid sites involved in type I functional divergence in duplicated haemoglobin gene in Antarctic Notothenioid fishes (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Selective enzymatic synthesis of sitosterol glucoside acyl derivatives and evaluation of their cytotoxicity on human cancer cell lines (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• The determinants of peptide aggregation: a molecular dynamics view (Comunicazione a convegno) (Prodotto della ricerca)
• Analysis of dystroglycan in Teleost fishes (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Identification of keratoepithelin in human skeletal muscle (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• The ectodomain of beta-dystroglycan, a biomarker of cancer progression? (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• The cystatin structure: a case of non hierarchical protein folding (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Mutagenesis of the ±- and ²- dystroglycan interface (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Biochemical and cellular analysis of the dystroglycan alpha/beta interface (Comunicazione a convegno) (Prodotto della ricerca)
• Identification of the MMP-9 cleavage site on the recombinant b-dystroglycan ectodomain (Abstract/Poster in convegno) (Prodotto della ricerca)
• Evaluating the role of the dystroglycan alpha/beta interface in human muscular dystrophies (Abstract/Poster in convegno) (Prodotto della ricerca)
• Amyloid-beta peptide(1-42) affects ATP release from human erythrocytes (Abstract/Poster in convegno) (Prodotto della ricerca)
• Ligands modulate the functional motion of Hsp90 by driving hte residue-residue interdomain communication: a molecular dynamics study (Abstract/Poster in convegno) (Prodotto della ricerca)
• Changes in erythrocyte deformability in Alzheimer's disease: a role for nitric oxide synthase (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Analysis at the molecular level of the interaction between ±-dystroglycan and ²-dystroglycan and assessment of its implication for skeletal muscle physiopathology (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• HEMA intracellular concentrations and in vtiro cytotoxicity (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Modelling Signal Propagation Mechanisms and Ligand-Based Conformational Dynamics of the Hsp90 Molecular Chaperone Full Length Dimer (Comunicazione a convegno) (Prodotto della ricerca)
• Investigating and inhibiting peptide aggregation: what can simulations tell us? (Comunicazione a convegno) (Prodotto della ricerca)
• Corneal deposit of ciprofloxacin after Laser Sub-Epithelial Keratomileusis (LASEK) procedure. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Modeling TCR-p/MHC interactions associated with rheumatoid arthritis (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
• MicroRNA from human peripheral blood leukocytes and cardiovascular diseases (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
• Design of New Anticancer Agents (Contributo in volume (capitolo o saggio)) (Prodotto della ricerca)
• Molecular simulations of peptides: a useful tool for the development of new drugs and for the study of molecular recognition (Contributo in volume (capitolo o saggio)) (Prodotto della ricerca)
• Inhibition of telomerase activity in HL-60 cell line by methacrylic monomers. (Contributo in volume (capitolo o saggio)) (Prodotto della ricerca)
• Enzyme Reactivity Studied by Computer Simulations (Contributo in volume (capitolo o saggio)) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1201)
• Protein folding simulations: combining coarse-grained models and all-atom molecular dynamics (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Localization of synaptic proteins involved in neurosecretion in different membrane microdomains. (Articolo in rivista) (Prodotto della ricerca)
• Combined in silico and experimental approach for drug design: the binding mode of peptidic and non-peptidic inhibitors to hsp90 N-terminal domain. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• The role of cytosolic proteins in the insertion of tail-anchored proteins into phospholipid bilayers (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Insertion of a myc-tag within alpha-dystroglycan domains improves its biochemical and microscopic detection (Articolo in rivista) (Prodotto della ricerca)
• Dystroglycan is associated to the disulfide isomerase ERp57 (Articolo in rivista) (Prodotto della ricerca)
• beta-amyloid decreases detectable endothelial nitric oxide synthase in human erythrocytes: a role for membrane acetylcholinesterase (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Molecular interactions of a proline-rich peptide with the SH3 domain of tyrosine-protein kinase: a computational approach (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
• La biologia computazionale e il suo ruolo nella ricerca biomedica: dalla modellistica di proteine al disegno di nuovi farmaci. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
• Il Distroglicano, un recettore coinvolto nelle distrofie muscolari: dalla biochimica cellulare ad un modello murino. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
• Mutazione di splicing nel gene OPHN1 determina la produzione di tre trascritti alternativi ed altrettante isoforme proteiche non funzionanti (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Caffeine inhibits erythrocyte membrane derangement by antioxidant activity and blocking caspase 3 activation (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• PHOX2B regulates its own expression by a transcriptional auto-regulatory mechanism (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Protein kinase C-mediated phosphorylation of the BGT1 epithelial gamma-aminobutyric acid transporter regulates its association with LIN7 PDZ proteins - A post-translational mechanism regulating transporter surface density (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• MicroRNAs in human blood leukocytes and coronary angioplasy (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
• Enzymatic processing by MMP-2 and MMP-9 of wild-type and mutated mouse ss-dystroglycan (Articolo in rivista) (Prodotto della ricerca)
• Understanding the binding of daunorubicin and doxorubicin to NADPH-dependent cytosolic reductases by computational methods (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Structure, function and molecular adaptations of haemoglobins of the polar cartilaginous fish Bathyraja eatonii and Raja hyperborea (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• NMR-based modelling and binding studies of a ternary complex between chicken liver bile acid binding protein and bile acids. (Articolo in rivista) (Prodotto della ricerca)
• Structure-function studies of the polar cartilaginous fish Bathyraja eatonii and Raja hyperborea haemoglobins using homology modelling and molecular docking. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• DAG1, no gene for RNA regulation? (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Modeling and molecular dynamics of alpha-dystroglycan's C-terminus reveals the presence of an Ig-like domain encompassing its beta-dystroglycan binding epitope (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
• Oxygen binding in hemoglobins from Arctic and Antarctic species: structural basis of the low enthalpy change (Contributo in atti di convegno) (Prodotto della ricerca)
• S100b protects IMR-32 cells against Ab(1-42) induced neurotoxicity via modulation of apoptotic genes expression (Articolo in rivista) (Prodotto della ricerca)
• Probing the stability of the \"naked\" mucin-like domain of human alpha-dystroglycan (Articolo in rivista) (Prodotto della ricerca)
• Antiepileptic carbamazepine drug treatment induces alteration of membrane in red blood cells: Possible positive effects on metabolism and oxidative stress (Articolo in rivista) (Prodotto della ricerca)
• Increased levels of expression of dystroglycan may protect the heart (Articolo in rivista) (Prodotto della ricerca)
• The Multiple Affinities of alpha-Dystroglycan (Articolo in rivista) (Prodotto della ricerca)
• New therapeutic targets in rheumatoid arthritis: selective inhibitors of recognition of TCR/MHCII-collagen complex. Drug (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• FRAP analysis of dystroglycan, a membrane receptor involved in congenital muscular dystrophies (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• New C-alkylcalix[4]resorcinarenes: a Computational Study (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
• Naturally glycated hemoglobin: computational molecular model and functional studies (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
• Alpha Dystroglycan monoclonal antibodies (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
• Immunostaining of the sarcolemma with a new monoclonal antibody against alpha-dystroglycan core and its relevance to diagnosis (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
• Modeling the interactions of T-cell receptor with MHCII bound to type II collagen peptide 261-273 (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
• Inibitori dell'interazione TCR/MHCII-Collagen interaction inhibitors useful for the treatment of rheumatoid arthritis (Brevetto) (Prodotto della ricerca)
• Molecular interactions of hemoglobin with resveratrol: potential protective antioxidant role and metabolic adaptations of the erythrocyte (Articolo in rivista) (Prodotto della ricerca)
• Neuroglobin expression and oxidant/antioxidant balance after graded traumatic brain injury in the rat (Articolo in rivista) (Prodotto della ricerca)
• Investigating the activation mechanism of Ser/Thr protein kinase Stkp from S. pneumoniae: insights from MD simulations (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
• Analisi strutturale e funzionale dei domini del distroglicano: ruolo per la stabilità del muscolo e aspetti fisiopatologici (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
• Structural and functional characteristics of a basic salivary proline-rich peptide (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Perturbation of the alpha/beta-dystroglycan interaction: consequences for skeletal muscle stability (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Alpha-Dystroglycan is a potential target of matrix metalloproteinase MMP-2 (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
• Nuovi target terapeutici per le malattie autoimmuni: ricerca di inibitori selettivi del complesso TCR/MHCII-peptidev (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
• Insights from molecular dynamics simulations: Structural basis for the V567D mutation-induced instability of zebrafish alpha-dystroglycan and comparison with the murine model (Articolo in rivista) (Prodotto della ricerca)
• A new monoclonal antibody DAG-6F4 against human alpha-dystroglycan reveals reduced core portein in some, but not all, dystroglycanopathy patients (Articolo in rivista) (Prodotto della ricerca)
• http://www.cnr.it/ontology/cnr/individuo/prodotto/ID188904
• http://www.cnr.it/ontology/cnr/individuo/prodotto/ID192891
• http://www.cnr.it/ontology/cnr/individuo/prodotto/ID192897

Gestore di

• MARIA CRISTINA DE ROSA (Persona)

Modulo

• Strutturistica NMR e modellistica molecolare di proteine legate a processi patologici (PM.P01.026) (Commessa)

Istituto esecutore di

• Istituto di chimica del riconoscimento molecolare (ICRM) (Istituto)

Descrizione di

• Descrizione del modulo "Modellistica molecolare di proteine legate a processi patologici (PM.P01.026.002)" (Descrizione modulo)
• Descrizione collaborazioni del modulo "Modellistica molecolare di proteine legate a processi patologici (PM.P01.026.002)" (Descrizione collaborazioni)
• Descrizione dello stato di avanzamento delle attività del modulo "Modellistica molecolare di proteine legate a processi patologici (PM.P01.026.002)" (Descrizione stato avanzamento attività)