http://www.cnr.it/ontology/cnr/individuo/modulo/ID4224
Studi strutturali e funzionali di proteine di interesse biomedico e biotecnologico (PM.P01.023.001)
- Type
- Label
- Studi strutturali e funzionali di proteine di interesse biomedico e biotecnologico (PM.P01.023.001) (literal)
- Prodotto
- METHOD FOR THE HUMANIZATION OF ANTIBODIES AND HUMANIZED ANTIBODIES THEREBY OBTAINED (Brevetto) (Prodotto della ricerca)
- Direct intracellular selection and biochemical characterization of a recombinant anti-proNGF single chain antibody fragment. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Inibizione dellangiogenesi mediante un antagonista selettivo dellintegrina ±V²3 endoteliale: studi in vitro e in vivo (Abstract/Poster in convegno) (Prodotto della ricerca)
- Acyl peptide hydrolase as new target protease of the PEBP inhibitor proteins: functional analysis and modeling study (Abstract/Poster in convegno) (Prodotto della ricerca)
- Purification, crystallization, X-ray diffraction analysis and phasing of a fungal 17 beta-hydroxysteroid dehydrogenase (Contributo in atti di convegno) (Prodotto della ricerca)
- The yin and the yan of torpedo californica acetylcholinesterase reversible and pseudo irreversible inhibition: a structural and mechanistic outlook (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Alzheimer's disease and chronic neuropatic pain: a structural neurobiology perspective (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Preparation of enzyme crystals with tunable morphology in membrane crystallizers (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Base and sugar radical reactivity in nucleic acids (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Immobilization and functionalization of biomacromolecules on unoxidized silicon surfaces: methodology and AFM step-by-step characterization (Abstract/Poster in convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1304)
- Regulation of gene expression in the liver and adipose tissue by a new dual PPARalpha/gamma agonist (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Remarkable analgesic effects of an anti-NGF monoclonal antibody with function neutralizing properties (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Conformational plasticity of proNGF (Articolo in rivista) (Prodotto della ricerca)
- Frontal affinity chromatography with MS detection of the ligand binding domain of PPARg receptor: Ligand affinity screening and stereoselective ligand-macromolecule interaction. (Articolo in rivista) (Prodotto della ricerca)
- High Throughput Protein Crystallography: A Drug Discovery Tool (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases (Articolo in rivista) (Prodotto della ricerca)
- Structural basis for the selectivity of recombinant mouse short proNGF versus NGF towards its binding partners. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Evaluation of the anti-angiogenic properties of the new selective aVb3 integrin antagonist RGDechiHCit. (Articolo in rivista) (Prodotto della ricerca)
- Investigation of the Best Conditions to Obtain c(RGDfK) Peptide on Solid Phase (Articolo in rivista) (Prodotto della ricerca)
- Insight into the structure of an endopolygalacturonase from the phytopathogen Burkholderia cepacia: A biochemical and computational study (Articolo in rivista) (Prodotto della ricerca)
- Insights into subtle conformational differences in the substrate-binding loop of fungal 17beta-hydroxysteroid dehydrogenase: a combined structural and kinetic approach (Articolo in rivista) (Prodotto della ricerca)
- Insights into the fatty acid chain length specificity of the carboxylesterase PA3859 from Pseudomonas aeruginosa: A combined structural, biochemical and computational study. (Articolo in rivista) (Prodotto della ricerca)
- SYNTHESIS, Characterization and biological evaluation of ureidofibrate-like derivatives endowed with Peroxisome Proliferator-Activated Receptor Activity (Articolo in rivista) (Prodotto della ricerca)
- Trans-cis-cis-[RuCl2(DMSO)2(2-amino-5-methyl-thiazole)2], (PMRu52), a novel ruthenium(II) compound acting as a strong inhibitor of cathepsin B (Articolo in rivista) (Prodotto della ricerca)
- Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation (Articolo in rivista) (Prodotto della ricerca)
- Crystal structure of wild-type chaperonin GroEL (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Novel recombinant antibodies against AD biomarkers linked to neurotrophin signalling as potential diagnostic tools (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- A humanized anti-NGF antibody with analgesic properties (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- High Throughput Protein Crystallography: A Drug Discovery Tool (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Crystal structure of wild-type chaperonin GroEL (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Outstanding plasmodicidal properties within a small panel of metallic compounds: Hints for the development of new metal-based antimalarials. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Structural and functional properties of mouse proNGF (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- New 2-Aryloxy-3-phenyl-propanoic Acids As Peroxisome Proliferator-Activated Receptors alpha/gamma Dual Agonists with Improved Potency and Reduced Adverse Effects on skeletal muscle function (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Mono and tetranuclear gold(I) complexes of tris(1-benzylimidazole-2-yl)phosphine (Articolo in rivista) (Prodotto della ricerca)
- Humanization of therapeutic neutralizing antibodies with analgesic effects (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Insights into the structure and function of mouse proNGF (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Macromolecular Crystallography (Contributo in volume (capitolo o saggio)) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1201)
- Affinity of the anthracycline antitumor drugs Doxorubicin and Sabarubicin for human telomeric G-quadruplex structures. (Articolo in rivista) (Prodotto della ricerca)
- Crystal structure of the PPAR-gamma ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Structural features of Apramycin bound at the bacterial ribosome A site as detected by NMR and CD spectroscopy. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- X-ray crystal structure of a p-hydroxycalix[6]arene derivative (Articolo in rivista) (Prodotto della ricerca)
- Synthesis and characterization of new ³ sulphate PNA (Abstract/Poster in convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1304)
- Oxyfunctionalization of Calixarene Quinone Rings (Articolo in rivista) (Prodotto della ricerca)
- In vitro receptor binding properties of a painless NGF mutein, linked to Hereditary Sensory Autonomic Neuropathy type V (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- New antiviral drugs for the treatment of the common cold (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- (3R,5S)-5(3)-Carboxy-3,4,5,6-tetrahydro-2H-1,4-thiazin-4-ium-3(5)-carboxylate (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Refolding of the Cupressus arizonica major pollen allergen Cup a1.02 overexpressed in Escherichia coli. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Molecular dynamics simulation of the interaction between the complex iron-sulfur flavoprotein glutamate synthase and its substrates. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Hybrid alpha/beta3-peptides with proteinogenic side chains. Monosubstituted analogues of the chemotactic tripeptide For-Met-Leu-Phe-OMe. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Improved lipid metabolism and reduced fat deposition in a mouse model of diet-induced obesity (DIO) with a new dual PPARalpha/gamma ligand (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Ectopic expression of maize polyamine oxidase and pea copper amine oxidase in the cell wall of tobacco plants (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Overexpression system and biochemical profile of CTX-M-3 extended-spectrum beta-lactamase expressed in Escherichia coli. (Articolo in rivista) (Prodotto della ricerca)
- Solvent-free synthesis of azole carboximidamides. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Design, modelling, synthesis and biological evaluation of peptidomimetic phosphinates as inhibitors of matrix metalloproteinases MMP-2 and MMP-8. (Articolo in rivista) (Prodotto della ricerca)
- Question: What is the biological function of the polyamines? (Articolo in rivista) (Prodotto della ricerca)
- Purification, crystallization and preliminary X-ray analysis of an acetylxylan esterase from Bacillus pumilus. Erratum. (Articolo in rivista) (Prodotto della ricerca)
- Purification, crystallization, X-ray diffraction analysis and phasing of a Fab fragment of monoclonal neuroantibody alphaD11 against nerve growth factor. (Articolo in rivista) (Prodotto della ricerca)
- Partial agonism in PPARs: the role of helix 3 (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- New insights into the intrinsic structural disorder of mouse proNGF (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- New insights into the intrinsic structural disorder of mouse proNGF (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Protein Crystallography for Drug Discovery: Selected Case Studies (Comunicazione a convegno) (Prodotto della ricerca)
- Radiolabeled Peptides, Structure and Analysis (Contributo in volume (capitolo o saggio)) (Prodotto della ricerca)
- Identification of novel dual peroxisome proliferator-activated receptor alpha/gamma ligands and characterization of their biochemical properties by 3D structural studies (Abstract/Poster in convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1304)
- Crystal Structure of PPARgamma Ligand Binding Domain complexed with a novel Partial Agonist: a new region of the hydrophobic pocket could be exploited for drug design (Abstract/Poster in convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1304)
- Structural determinants for the molecular promiscuity of mouse proNGF (Comunicazione a convegno) (Prodotto della ricerca)
- Crystal structure of wild-type chaperonin GroEL (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Crystallization, X-ray diffraction analysis and phasing of carboxylesterase PA3859 from Pseudomonas aeruginosa. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Heterologous expression, purification, crystallization, X-ray analysis and phasing of the acetyl xylan esterase from Bacillus pumilus. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Potential Future Application in Structural Biology of an X-FEL at SPARX. A New Scientific Landscape: Expectations, Challenges and Limitations (Comunicazione a convegno) (Prodotto della ricerca)
- Protein Crystallography: Basic Aspects (Comunicazione a convegno) (Prodotto della ricerca)
- Novel dual PPARalpha/gamma agonists, as potential hypoglycemic and anti diabetic agents (Abstract/Poster in convegno) (Prodotto della ricerca)
- Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The base excsion repair: mechnism and its relevance for cancer susceptibility (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819) (Articolo in rivista) (Prodotto della ricerca)
- CNS disorders and strcutural neurobiology: a prospective paradigm for drug discovery (Abstract/Comunicazione in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1305)
- Reassessing the melatonin pharmacophore--enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue (Articolo in rivista) (Prodotto della ricerca)
- Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates. (Articolo in rivista) (Prodotto della ricerca)
- Structural Neurobiology: A Prospective Paradigm for Drug Discovery (Comunicazione a convegno) (Prodotto della ricerca)
- Intrinsic structural disorder of mouse proNGF (Comunicazione a convegno) (Prodotto della ricerca)
- Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor-gamma ligand-binding domain in the complex with two enantiomeric ligands (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Crystal Structures of the Complexes between PPARgamma and two new ligands with dual activity (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Towards an understanding of the structure and dynamic of mouse proNGF (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Flavin-containing polyamine oxidase is a hydrogen peroxide source in the oxidative response to the protein phosphatase inhibitor cantharidin in Zea mays L. (Articolo in rivista) (Prodotto della ricerca)
- Functions of amine oxidases in plant development and defence. (Articolo in rivista) (Prodotto della ricerca)
- New drugs with anticholestatic activity (Brevetto) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1601)
- Studies on the activity of a new ligand of the peroxisome proliferator-activated receptors (PPARs) (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Le proteine si mettono in posa: fotogrammi ai raggi X della loro struttura tridimensionale (Comunicazione a convegno) (Prodotto della ricerca)
- On the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands. (Abstract/Poster in convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1304)
- A new mechanism for Alzheimer neurodegeneration: functional antagonism between proNGF, mature NGF and their receptors. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Crystallization, X-ray Diffraction Analysis and Phasing of 17beta-Hydroxysteroid Dehydrogenase from fungus Cochliobolus lunatus (Articolo in rivista) (Prodotto della ricerca)
- Investigation of quaternary structure of macromolecules using small-angle X-ray scattering data with program package ATSAS (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Structural and functional studies of carboxylesterase PA3859 from Pseudomonas aeruginosa (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Protein crystallography: basic aspects & applications (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- The response to DNA damage of terminally differentiated cells (Abstract/Poster in convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1304)
- DNA Damage and radical reactions: mechanistic aspects, formation in cells and repair studies (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Synthesis of enantiomeric menthol derivatives for forming and probing chiral surfaces. X- ray crystal and molecular structures of (+)-(1S,2R,5S)-1-(2-tricyanovinyl-1H-pyrrol-1- yl methoxy)-2-isopropyl-5-methylcyclohexane (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Structural analysis of two distinct dihydroflavonol 4-reductases in Gerbera Hybrids (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Membrane crystallization of lysozyme under forced solution flow (Articolo in rivista) (Prodotto della ricerca)
- Evaluation and computational characterization of the facilitated transport of Glc carbon C-1 oxime reactivators across a blood brain barrier model (Articolo in rivista) (Prodotto della ricerca)
- Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group. (Articolo in rivista) (Prodotto della ricerca)
- Single cycle structure-based humanization of an anti-nerve growth factor therapeutic antibody (Articolo in rivista) (Prodotto della ricerca)
- Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors alpha/gamma dual agonists (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Enzymatic systems with some potentials in biocatalysis (Abstract/Poster in convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1304)
- 8-Oxoguanide DNA damage: at the crossroad of alternative repair pathway (Articolo in rivista) (Prodotto della ricerca)
- Atomic force microscopy analysis of crystalline silicon functionalization with oligonucleotides (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- X-Ray Diffraction @ Elettra Synchrotron: Atomic Insight Of Your Biomedical Target. (Contributo in atti di convegno) (Prodotto della ricerca)
- New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists able ti up regulate the mitochondrial carnitine shuttle system gene expression. (Articolo in rivista) (Prodotto della ricerca)
- The Conundrum of the High-Affinity NGF Binding Site Formation Unveiled? (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Verso la Medicina personalizzata sviluppo su basi molecolare di (Comunicazione a convegno) (Prodotto della ricerca)
- Synthesis of novel L-diamino acid-based cationic peptide for biomedical applications (Abstract/Poster in convegno) (Prodotto della ricerca)
- Aptamers as innovative diagnostic and therapeutic agents in the central nervous system. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- MULTI-TARGET-DIRECTED LIGANDS IN ALZHEIMER'S DISEASE TREATMENT (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- A cationic ZnII porphyrazine induces a stable parallel G-quadruplex conformation in human telomeric DNA (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Chiral HPLC Separation and Absolute Configuration of Novel S-DABO Derivatives (Articolo in rivista) (Prodotto della ricerca)
- Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S-1 ' Subsite of Matrix Metalloproteinase 8 (MMP-8) (Articolo in rivista) (Prodotto della ricerca)
- Structural Insight into Peroxisome Proliferator-Activated Receptor ³ Binding of Two Ureidofibrate-Like Enantiomers by Molecular Dynamics, Cofactor Interaction Analysis, and Site-Directed Mutagenesis (Articolo in rivista) (Prodotto della ricerca)
- Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives. (Articolo in rivista) (Prodotto della ricerca)
- In vitro characterization of Arabidopsis CP12 isoforms reveals common biochemical and molecular properties. (Articolo in rivista) (Prodotto della ricerca)
- Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- A comparative analysis of the structural, functional and biological differences between Mouse and Human Nerve Growth Factor. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: Design, synthesis, structureaffinity and structureselectivity relationships (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- X-ray crystal structure and conformation of N-(tertbutyloxycarbonyl)-L-methionyl-(1-aminocyclopent-3-ene-1-carbonyl)-L-phenylalanine methyl ester (Boc(0)-Met(1)-Cpg(2)-Phe(3)-OMe). (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- HPLC enantioseparation and absolute configuration of novel anti-inflammatory pyrrole derivatives. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Hemoglobin, pH and DPG/chloride shifting. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Oxygenation of calixarene phenol rings. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Enantiomers of C(5)-chiral 1-acetyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives: Analytical and semipreparative HPLC separation, chiroptical properties, absolute configuration, and inhibitory activity against monoamine oxidase. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Structure of S35C flavodoxin mutant from Desulfovibrio vulgaris in the semiquinone state. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Isolation, characterization, and heterologous expression of a carboxylesterase of Pseudomonas aeruginosa PAO1. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Neutralization of NGF-TrkA receptor interaction by the novel antagonistic anti-TrkA monoclonal antibody MNAC13: A structural insight. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Census of solo LuxR genes in prokaryotic genomes (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Structural and functional properties of mouse proNGF (Articolo in rivista) (Prodotto della ricerca)
- N-Hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: mode of binding in a complex with MMP-8. (Articolo in rivista) (Prodotto della ricerca)
- Study of the mode of action of a polygalacturonase from the phytopathogen Burkholderia cepacia. (Articolo in rivista) (Prodotto della ricerca)
- Structural and biochemical analysis of the Rv0805 cyclic nucleotide phosphodiesterase from Mycobacterium tuberculosis. (Articolo in rivista) (Prodotto della ricerca)
- Pseudomonas PA3859: from structure to function (Contributo in atti di convegno) (Prodotto della ricerca)
- Intrinsic structural disorder of mouse proNGF (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Molecular Assembly of Distal p-H-Calix[4]dihydroquinone Units (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Two distinct dihydroflavonol 4-reductases involved in anthocyanin biosynthesis in Gerbera hybrids (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Structural Insights into a Novel Interkingdom Signaling Circuit by Cartography of the Ligand-Binding Sites of the Homologous QuorumSensing LuxR-Family (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- NGF conformational changes in the context of proNGF: NMR structural studies (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Quorum sensing signaling studies in Pseudomonas syringae pv. actinidae (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Functional and structural study of the dimeric inner membrane protein SbmA (Articolo in rivista) (Prodotto della ricerca)
- The Kiwifruit Emerging Pathogen Pseudomonas syringae pv. actinidiae Does Not Produce AHLs but Possesses Three LuxR Solos (Articolo in rivista) (Prodotto della ricerca)
- Towards a comprehension of the structure of mouse proNGF (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Unraveling the binding mode of the neutralizing neuroantibody aD11 to NGF (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Structural and functional studies of carbohydrate esterase family 7 enzymes (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Large scale analysis of transcription factor TTF-1/NKX2.1 target genes in GnRH secreting cell line GT1-7 (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Peptides containing 4-amino-1,2-dithiolane-4-carboxylic acid (Adt): conformation of Boc-Adt-Adt-NHMe and NH...S interactions (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- On the mechanism of partial agonism: crystal structures of the peroxisome proliferators-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Structural insight into the crucial role of ligand chirality in the activation of PPARs by crystallographic methods (Articolo in rivista) (Prodotto della ricerca)
- Structure of 2-C-(hydroxymethyl)-D-ribose (hamamelose) in the solid-state analyzed by CP MAS NMR and X-ray crystallography. (Articolo in rivista) (Prodotto della ricerca)
- Stereoselectivity by enantiomeric inhibitors of matrix metalloproteinase-8: new insights from molecular dynamics simulations (Articolo in rivista) (Prodotto della ricerca)
- Isolation, heterologous expression and characterization of an endo-polygalacturonase produced by the phytopathogen Burkholderia cepacia (Articolo in rivista) (Prodotto della ricerca)
- The Interaction of Kanamycin A with the Bacterial Ribosomal A-Site: Effect of Cu(II) on the Adduct (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Three-dimensional structure of a complex of galanthamine (Nivalin) with acetylcholinesterase from Torpedo californica: implications for the design of new anti-Alzheimer drugs. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The role of Cockayne syndrome proteins in the repair of endogenous DNA damage. (Abstract/Poster in convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1304)
- Purification, crystallization and preliminary X-ray analysis of the Fab fragment from MNAC13, a novel antagonistic anti- (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Structural and functional studies of the xylan-degrading pathway of B. pumilus (Abstract/Poster in convegno) (Prodotto della ricerca)
- Role of metal ions on the activity of Mycobacterium tuberculosis pyrazinamidase (Articolo in rivista) (Prodotto della ricerca)
- Regio- and Diastereoselective Synthesis and X-ray Structure Determination of (+)-2-Deoxyoryzalexin S from (+)-Podocarpic Acid. Structural Nonidentity with Its Nominal Natural Isolated Enantiomer. (Articolo in rivista) (Prodotto della ricerca)
- Dissecting NGF interactions with TrkA and p75 receptors by structural and functional studies of an anti-NGF neutralizing antibody (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The structure of the N-terminal region of murine skeletal muscle alpha-dystroglycan discloses a modular architecture (Articolo in rivista) (Prodotto della ricerca)
- I canali della vita: I buchi nelle cellule vincono il Nobel (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Codice
- Anno di chiusura previsto
- 2017-01-01T00:00:00+01:00 (literal)
- Istituto esecutore
- Primo anno di attività
- 2005-01-01T00:00:00+01:00 (literal)
- Abstract
- Le tematiche di ricerca sono rivolte allo sviluppo ed applicazione di metodologie chimiche, biochimiche, biofisiche (CD, DLS, IR, micro calorimetria, termo fluorimetria, fluorescenza, risonanza plasmonica di superfice), biocristallografiche, spettroscopia NMR e di biologia molecolare per la caratterizzazione di proteine, complessi proteine-ligandi e enzimi-inibitori a sostegno della progettazione e sviluppo di farmaci con migliorate proprietà farmacologiche ed elevata specificità-selettività.
L'attività di ricerca è focalizzata alla comprensione, mediante un approccio multidisciplinare, dei meccanismi che regolano il riconoscimento molecolare, la catalisi enzimatica, la trascrizione del DNA ed il folding proteico che sono alla base di numerose patologie. Le metodiche utilizzate includono; l'isolamento, l'espressione e la purificazione di proteine ricombinanti e la loro caratterizzazione biochimica e biofisica, gli studi strutturali in soluzione ed allo stato solido tramite diffrazione di raggi X con utilizzo della luce di sincrotrone, lo studio delle relazioni struttura-attività-funzione, e la modellistica molecolare. (literal)
- Nome
- Studi strutturali e funzionali di proteine di interesse biomedico e biotecnologico (literal)
- Descrizione
- Modulo di
- Gestore
Incoming links:
- Prodotto di
- Atomic force microscopy analysis of crystalline silicon functionalization with oligonucleotides (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Towards a comprehension of the structure of mouse proNGF (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Unraveling the binding mode of the neutralizing neuroantibody aD11 to NGF (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Structural and functional studies of carbohydrate esterase family 7 enzymes (Contributo in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1301)
- Purification, crystallization and preliminary X-ray analysis of the Fab fragment from MNAC13, a novel antagonistic anti- (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Dissecting NGF interactions with TrkA and p75 receptors by structural and functional studies of an anti-NGF neutralizing antibody (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819) (Articolo in rivista) (Prodotto della ricerca)
- Reassessing the melatonin pharmacophore--enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue (Articolo in rivista) (Prodotto della ricerca)
- Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates. (Articolo in rivista) (Prodotto della ricerca)
- Flavin-containing polyamine oxidase is a hydrogen peroxide source in the oxidative response to the protein phosphatase inhibitor cantharidin in Zea mays L. (Articolo in rivista) (Prodotto della ricerca)
- Functions of amine oxidases in plant development and defence. (Articolo in rivista) (Prodotto della ricerca)
- Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Crystal structure of wild-type chaperonin GroEL (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Crystallization, X-ray diffraction analysis and phasing of carboxylesterase PA3859 from Pseudomonas aeruginosa. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Heterologous expression, purification, crystallization, X-ray analysis and phasing of the acetyl xylan esterase from Bacillus pumilus. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Design, modelling, synthesis and biological evaluation of peptidomimetic phosphinates as inhibitors of matrix metalloproteinases MMP-2 and MMP-8. (Articolo in rivista) (Prodotto della ricerca)
- Question: What is the biological function of the polyamines? (Articolo in rivista) (Prodotto della ricerca)
- Purification, crystallization and preliminary X-ray analysis of an acetylxylan esterase from Bacillus pumilus. Erratum. (Articolo in rivista) (Prodotto della ricerca)
- Purification, crystallization, X-ray diffraction analysis and phasing of a Fab fragment of monoclonal neuroantibody alphaD11 against nerve growth factor. (Articolo in rivista) (Prodotto della ricerca)
- Overexpression system and biochemical profile of CTX-M-3 extended-spectrum beta-lactamase expressed in Escherichia coli. (Articolo in rivista) (Prodotto della ricerca)
- X-ray crystal structure of a p-hydroxycalix[6]arene derivative (Articolo in rivista) (Prodotto della ricerca)
- Oxyfunctionalization of Calixarene Quinone Rings (Articolo in rivista) (Prodotto della ricerca)
- Crystal structure of wild-type chaperonin GroEL (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Outstanding plasmodicidal properties within a small panel of metallic compounds: Hints for the development of new metal-based antimalarials. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- New 2-Aryloxy-3-phenyl-propanoic Acids As Peroxisome Proliferator-Activated Receptors alpha/gamma Dual Agonists with Improved Potency and Reduced Adverse Effects on skeletal muscle function (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Structural features of Apramycin bound at the bacterial ribosome A site as detected by NMR and CD spectroscopy. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Insights into subtle conformational differences in the substrate-binding loop of fungal 17beta-hydroxysteroid dehydrogenase: a combined structural and kinetic approach (Articolo in rivista) (Prodotto della ricerca)
- SYNTHESIS, Characterization and biological evaluation of ureidofibrate-like derivatives endowed with Peroxisome Proliferator-Activated Receptor Activity (Articolo in rivista) (Prodotto della ricerca)
- Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation (Articolo in rivista) (Prodotto della ricerca)
- Three-dimensional structure of a complex of galanthamine (Nivalin) with acetylcholinesterase from Torpedo californica: implications for the design of new anti-Alzheimer drugs. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The Interaction of Kanamycin A with the Bacterial Ribosomal A-Site: Effect of Cu(II) on the Adduct (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Stereoselectivity by enantiomeric inhibitors of matrix metalloproteinase-8: new insights from molecular dynamics simulations (Articolo in rivista) (Prodotto della ricerca)
- Isolation, heterologous expression and characterization of an endo-polygalacturonase produced by the phytopathogen Burkholderia cepacia (Articolo in rivista) (Prodotto della ricerca)
- Structure of 2-C-(hydroxymethyl)-D-ribose (hamamelose) in the solid-state analyzed by CP MAS NMR and X-ray crystallography. (Articolo in rivista) (Prodotto della ricerca)
- Hybrid alpha/beta3-peptides with proteinogenic side chains. Monosubstituted analogues of the chemotactic tripeptide For-Met-Leu-Phe-OMe. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Ectopic expression of maize polyamine oxidase and pea copper amine oxidase in the cell wall of tobacco plants (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Solvent-free synthesis of azole carboximidamides. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Refolding of the Cupressus arizonica major pollen allergen Cup a1.02 overexpressed in Escherichia coli. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Molecular dynamics simulation of the interaction between the complex iron-sulfur flavoprotein glutamate synthase and its substrates. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Crystal structure of the PPAR-gamma ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- New antiviral drugs for the treatment of the common cold (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- (3R,5S)-5(3)-Carboxy-3,4,5,6-tetrahydro-2H-1,4-thiazin-4-ium-3(5)-carboxylate (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- In vitro receptor binding properties of a painless NGF mutein, linked to Hereditary Sensory Autonomic Neuropathy type V (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Insight into the structure of an endopolygalacturonase from the phytopathogen Burkholderia cepacia: A biochemical and computational study (Articolo in rivista) (Prodotto della ricerca)
- Insights into the fatty acid chain length specificity of the carboxylesterase PA3859 from Pseudomonas aeruginosa: A combined structural, biochemical and computational study. (Articolo in rivista) (Prodotto della ricerca)
- Trans-cis-cis-[RuCl2(DMSO)2(2-amino-5-methyl-thiazole)2], (PMRu52), a novel ruthenium(II) compound acting as a strong inhibitor of cathepsin B (Articolo in rivista) (Prodotto della ricerca)
- Mono and tetranuclear gold(I) complexes of tris(1-benzylimidazole-2-yl)phosphine (Articolo in rivista) (Prodotto della ricerca)
- Affinity of the anthracycline antitumor drugs Doxorubicin and Sabarubicin for human telomeric G-quadruplex structures. (Articolo in rivista) (Prodotto della ricerca)
- Conformational plasticity of proNGF (Articolo in rivista) (Prodotto della ricerca)
- Frontal affinity chromatography with MS detection of the ligand binding domain of PPARg receptor: Ligand affinity screening and stereoselective ligand-macromolecule interaction. (Articolo in rivista) (Prodotto della ricerca)
- Evaluation of the anti-angiogenic properties of the new selective aVb3 integrin antagonist RGDechiHCit. (Articolo in rivista) (Prodotto della ricerca)
- Investigation of the Best Conditions to Obtain c(RGDfK) Peptide on Solid Phase (Articolo in rivista) (Prodotto della ricerca)
- Molecular Assembly of Distal p-H-Calix[4]dihydroquinone Units (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Intrinsic structural disorder of mouse proNGF (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Structural and functional properties of mouse proNGF (Articolo in rivista) (Prodotto della ricerca)
- N-Hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: mode of binding in a complex with MMP-8. (Articolo in rivista) (Prodotto della ricerca)
- Structural and biochemical analysis of the Rv0805 cyclic nucleotide phosphodiesterase from Mycobacterium tuberculosis. (Articolo in rivista) (Prodotto della ricerca)
- Study of the mode of action of a polygalacturonase from the phytopathogen Burkholderia cepacia. (Articolo in rivista) (Prodotto della ricerca)
- Structure of S35C flavodoxin mutant from Desulfovibrio vulgaris in the semiquinone state. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Isolation, characterization, and heterologous expression of a carboxylesterase of Pseudomonas aeruginosa PAO1. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Neutralization of NGF-TrkA receptor interaction by the novel antagonistic anti-TrkA monoclonal antibody MNAC13: A structural insight. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Hemoglobin, pH and DPG/chloride shifting. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Oxygenation of calixarene phenol rings. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Enantiomers of C(5)-chiral 1-acetyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives: Analytical and semipreparative HPLC separation, chiroptical properties, absolute configuration, and inhibitory activity against monoamine oxidase. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: Design, synthesis, structureaffinity and structureselectivity relationships (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- X-ray crystal structure and conformation of N-(tertbutyloxycarbonyl)-L-methionyl-(1-aminocyclopent-3-ene-1-carbonyl)-L-phenylalanine methyl ester (Boc(0)-Met(1)-Cpg(2)-Phe(3)-OMe). (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- HPLC enantioseparation and absolute configuration of novel anti-inflammatory pyrrole derivatives. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Chiral HPLC Separation and Absolute Configuration of Novel S-DABO Derivatives (Articolo in rivista) (Prodotto della ricerca)
- Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S-1 ' Subsite of Matrix Metalloproteinase 8 (MMP-8) (Articolo in rivista) (Prodotto della ricerca)
- Structural Insight into Peroxisome Proliferator-Activated Receptor ³ Binding of Two Ureidofibrate-Like Enantiomers by Molecular Dynamics, Cofactor Interaction Analysis, and Site-Directed Mutagenesis (Articolo in rivista) (Prodotto della ricerca)
- Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives. (Articolo in rivista) (Prodotto della ricerca)
- In vitro characterization of Arabidopsis CP12 isoforms reveals common biochemical and molecular properties. (Articolo in rivista) (Prodotto della ricerca)
- Aptamers as innovative diagnostic and therapeutic agents in the central nervous system. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- A cationic ZnII porphyrazine induces a stable parallel G-quadruplex conformation in human telomeric DNA (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Structural insight into the crucial role of ligand chirality in the activation of PPARs by crystallographic methods (Articolo in rivista) (Prodotto della ricerca)
- Crystallization, X-ray Diffraction Analysis and Phasing of 17beta-Hydroxysteroid Dehydrogenase from fungus Cochliobolus lunatus (Articolo in rivista) (Prodotto della ricerca)
- I canali della vita: I buchi nelle cellule vincono il Nobel (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Pseudomonas PA3859: from structure to function (Contributo in atti di convegno) (Prodotto della ricerca)
- Investigation of quaternary structure of macromolecules using small-angle X-ray scattering data with program package ATSAS (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Structural and functional studies of carboxylesterase PA3859 from Pseudomonas aeruginosa (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Protein crystallography: basic aspects & applications (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- A new mechanism for Alzheimer neurodegeneration: functional antagonism between proNGF, mature NGF and their receptors. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Le proteine si mettono in posa: fotogrammi ai raggi X della loro struttura tridimensionale (Comunicazione a convegno) (Prodotto della ricerca)
- On the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands. (Abstract/Poster in convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1304)
- Studies on the activity of a new ligand of the peroxisome proliferator-activated receptors (PPARs) (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Structural Neurobiology: A Prospective Paradigm for Drug Discovery (Comunicazione a convegno) (Prodotto della ricerca)
- Intrinsic structural disorder of mouse proNGF (Comunicazione a convegno) (Prodotto della ricerca)
- CNS disorders and strcutural neurobiology: a prospective paradigm for drug discovery (Abstract/Comunicazione in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1305)
- Synthesis of novel L-diamino acid-based cationic peptide for biomedical applications (Abstract/Poster in convegno) (Prodotto della ricerca)
- Verso la Medicina personalizzata sviluppo su basi molecolare di (Comunicazione a convegno) (Prodotto della ricerca)
- Structural and functional properties of mouse proNGF (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Humanization of therapeutic neutralizing antibodies with analgesic effects (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Insights into the structure and function of mouse proNGF (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Novel recombinant antibodies against AD biomarkers linked to neurotrophin signalling as potential diagnostic tools (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- A humanized anti-NGF antibody with analgesic properties (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- High Throughput Protein Crystallography: A Drug Discovery Tool (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- High Throughput Protein Crystallography: A Drug Discovery Tool (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Structural basis for the selectivity of recombinant mouse short proNGF versus NGF towards its binding partners. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Crystal structure of wild-type chaperonin GroEL (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Base and sugar radical reactivity in nucleic acids (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Immobilization and functionalization of biomacromolecules on unoxidized silicon surfaces: methodology and AFM step-by-step characterization (Abstract/Poster in convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1304)
- Regulation of gene expression in the liver and adipose tissue by a new dual PPARalpha/gamma agonist (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- The yin and the yan of torpedo californica acetylcholinesterase reversible and pseudo irreversible inhibition: a structural and mechanistic outlook (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Alzheimer's disease and chronic neuropatic pain: a structural neurobiology perspective (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Acyl peptide hydrolase as new target protease of the PEBP inhibitor proteins: functional analysis and modeling study (Abstract/Poster in convegno) (Prodotto della ricerca)
- Inibizione dellangiogenesi mediante un antagonista selettivo dellintegrina ±V²3 endoteliale: studi in vitro e in vivo (Abstract/Poster in convegno) (Prodotto della ricerca)
- Towards an understanding of the structure and dynamic of mouse proNGF (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor-gamma ligand-binding domain in the complex with two enantiomeric ligands (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Crystal Structures of the Complexes between PPARgamma and two new ligands with dual activity (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Potential Future Application in Structural Biology of an X-FEL at SPARX. A New Scientific Landscape: Expectations, Challenges and Limitations (Comunicazione a convegno) (Prodotto della ricerca)
- Protein Crystallography: Basic Aspects (Comunicazione a convegno) (Prodotto della ricerca)
- Protein Crystallography for Drug Discovery: Selected Case Studies (Comunicazione a convegno) (Prodotto della ricerca)
- Identification of novel dual peroxisome proliferator-activated receptor alpha/gamma ligands and characterization of their biochemical properties by 3D structural studies (Abstract/Poster in convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1304)
- Crystal Structure of PPARgamma Ligand Binding Domain complexed with a novel Partial Agonist: a new region of the hydrophobic pocket could be exploited for drug design (Abstract/Poster in convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1304)
- Structural determinants for the molecular promiscuity of mouse proNGF (Comunicazione a convegno) (Prodotto della ricerca)
- Improved lipid metabolism and reduced fat deposition in a mouse model of diet-induced obesity (DIO) with a new dual PPARalpha/gamma ligand (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Partial agonism in PPARs: the role of helix 3 (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- New insights into the intrinsic structural disorder of mouse proNGF (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- New insights into the intrinsic structural disorder of mouse proNGF (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Synthesis and characterization of new ³ sulphate PNA (Abstract/Poster in convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1304)
- Radiolabeled Peptides, Structure and Analysis (Contributo in volume (capitolo o saggio)) (Prodotto della ricerca)
- New drugs with anticholestatic activity (Brevetto) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1601)
- METHOD FOR THE HUMANIZATION OF ANTIBODIES AND HUMANIZED ANTIBODIES THEREBY OBTAINED (Brevetto) (Prodotto della ricerca)
- Peptides containing 4-amino-1,2-dithiolane-4-carboxylic acid (Adt): conformation of Boc-Adt-Adt-NHMe and NH...S interactions (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Preparation of enzyme crystals with tunable morphology in membrane crystallizers (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Membrane crystallization of lysozyme under forced solution flow (Articolo in rivista) (Prodotto della ricerca)
- On the mechanism of partial agonism: crystal structures of the peroxisome proliferators-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- DNA Damage and radical reactions: mechanistic aspects, formation in cells and repair studies (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Large scale analysis of transcription factor TTF-1/NKX2.1 target genes in GnRH secreting cell line GT1-7 (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Remarkable analgesic effects of an anti-NGF monoclonal antibody with function neutralizing properties (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Novel dual PPARalpha/gamma agonists, as potential hypoglycemic and anti diabetic agents (Abstract/Poster in convegno) (Prodotto della ricerca)
- Evaluation and computational characterization of the facilitated transport of Glc carbon C-1 oxime reactivators across a blood brain barrier model (Articolo in rivista) (Prodotto della ricerca)
- Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group. (Articolo in rivista) (Prodotto della ricerca)
- Single cycle structure-based humanization of an anti-nerve growth factor therapeutic antibody (Articolo in rivista) (Prodotto della ricerca)
- Enzymatic systems with some potentials in biocatalysis (Abstract/Poster in convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1304)
- New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists able ti up regulate the mitochondrial carnitine shuttle system gene expression. (Articolo in rivista) (Prodotto della ricerca)
- The role of Cockayne syndrome proteins in the repair of endogenous DNA damage. (Abstract/Poster in convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1304)
- Purification, crystallization, X-ray diffraction analysis and phasing of a fungal 17 beta-hydroxysteroid dehydrogenase (Contributo in atti di convegno) (Prodotto della ricerca)
- Synthesis of enantiomeric menthol derivatives for forming and probing chiral surfaces. X- ray crystal and molecular structures of (+)-(1S,2R,5S)-1-(2-tricyanovinyl-1H-pyrrol-1- yl methoxy)-2-isopropyl-5-methylcyclohexane (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The structure of the N-terminal region of murine skeletal muscle alpha-dystroglycan discloses a modular architecture (Articolo in rivista) (Prodotto della ricerca)
- The base excsion repair: mechnism and its relevance for cancer susceptibility (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 8-Oxoguanide DNA damage: at the crossroad of alternative repair pathway (Articolo in rivista) (Prodotto della ricerca)
- The response to DNA damage of terminally differentiated cells (Abstract/Poster in convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1304)
- Macromolecular Crystallography (Contributo in volume (capitolo o saggio)) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1201)
- Direct intracellular selection and biochemical characterization of a recombinant anti-proNGF single chain antibody fragment. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors alpha/gamma dual agonists (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Role of metal ions on the activity of Mycobacterium tuberculosis pyrazinamidase (Articolo in rivista) (Prodotto della ricerca)
- Regio- and Diastereoselective Synthesis and X-ray Structure Determination of (+)-2-Deoxyoryzalexin S from (+)-Podocarpic Acid. Structural Nonidentity with Its Nominal Natural Isolated Enantiomer. (Articolo in rivista) (Prodotto della ricerca)
- Structural and functional studies of the xylan-degrading pathway of B. pumilus (Abstract/Poster in convegno) (Prodotto della ricerca)
- Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases (Articolo in rivista) (Prodotto della ricerca)
- Two distinct dihydroflavonol 4-reductases involved in anthocyanin biosynthesis in Gerbera hybrids (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Structural Insights into a Novel Interkingdom Signaling Circuit by Cartography of the Ligand-Binding Sites of the Homologous QuorumSensing LuxR-Family (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- NGF conformational changes in the context of proNGF: NMR structural studies (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Quorum sensing signaling studies in Pseudomonas syringae pv. actinidae (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Functional and structural study of the dimeric inner membrane protein SbmA (Articolo in rivista) (Prodotto della ricerca)
- Structural analysis of two distinct dihydroflavonol 4-reductases in Gerbera Hybrids (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- A comparative analysis of the structural, functional and biological differences between Mouse and Human Nerve Growth Factor. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- MULTI-TARGET-DIRECTED LIGANDS IN ALZHEIMER'S DISEASE TREATMENT (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- The Kiwifruit Emerging Pathogen Pseudomonas syringae pv. actinidiae Does Not Produce AHLs but Possesses Three LuxR Solos (Articolo in rivista) (Prodotto della ricerca)
- X-Ray Diffraction @ Elettra Synchrotron: Atomic Insight Of Your Biomedical Target. (Contributo in atti di convegno) (Prodotto della ricerca)
- Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The Conundrum of the High-Affinity NGF Binding Site Formation Unveiled? (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Census of solo LuxR genes in prokaryotic genomes (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- http://www.cnr.it/ontology/cnr/individuo/prodotto/ID329063
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