http://www.cnr.it/ontology/cnr/individuo/modulo/ID2691
Sviluppo e meccanismo d'azione di analoghi nucleotidici e nucleosidici come composti antiproliferativi e antivirali : nuovi composti e nuovi bersagli per la terapia (ME.P04.004.001)
- Type
- Label
- Sviluppo e meccanismo d'azione di analoghi nucleotidici e nucleosidici come composti antiproliferativi e antivirali : nuovi composti e nuovi bersagli per la terapia (ME.P04.004.001) (literal)
- Prodotto
- Novel NNRTIs (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Second generation PBOs show enantioselective binding to the catalytic complex of HIV-1 RT wt and drug resistant mutants. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Characterization of novel N,N-DABOs as effective tight binding non-nucleoside inhibitors of HIV-1 RT. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Novel HIV-1 NNRTIs with reduced loss of potency against common drug-resistant mutations. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Enantioselectivity of ribonucleotide reductase: a first study using stereoisomers of pyrimidine 2'-azido-2'-deoxynucleosides. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- DNA polymerases and Diseases. (Articolo in rivista) (Prodotto della ricerca)
- Repair and translesion DNA polymerases as anticancer drug targets. (Articolo in rivista) (Prodotto della ricerca)
- CRYSTAL STRUCTURE OF THE HIV-1 REVERSE TRANSCRIPTASE BOUND TO A NUCLEOTIDE-COMPETITIVE REVERSE TRANSCRIPTASE INHIBITOR AND THE USE THEREOF (Brevetto) (Prodotto della ricerca)
- COMPOUNDS WITH DDX3 INHIBITORY ACTIVITY AND USES THEREOF (Brevetto) (Prodotto della ricerca)
- Monitoring oxidative damage responses in Daucos carota cell lines: contribution of DNA topoisomerase I (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- NEW 4-SUBSTITUTED DERIVATIVES OF PYRAZOLO[3,4-d]PYRIMIDINE AND PYRROLO[2,3-d]PYRIMIDINE AND USES THEREOF (Brevetto) (Prodotto della ricerca)
- Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d ]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma (Articolo in rivista) (Prodotto della ricerca)
- Ruolo funzionale della proteina Vif di HIV-1 nel processo di retrotrascrizione del genoma virale (Rapporti progetti di ricerca) (Prodotto della ricerca)
- Simplified analogs of Immucilin-G retain potent human purine nucleoside phosphorylase inhibitory activity. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Mutations coferring interclass antiretroviral drug resistance and their impact on HIV-1 replicative capacity (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- The solution structure of functionally active human proliferating cell nuclear antigen determined by small-angle neutron scattering (Articolo in rivista) (Prodotto della ricerca)
- Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3 '-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs (Articolo in rivista) (Prodotto della ricerca)
- Cytotoxicity of alpha-dicarbonyl compounds submitted to in vitro simulated digestion process (Articolo in rivista) (Prodotto della ricerca)
- Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides (Articolo in rivista) (Prodotto della ricerca)
- Dual mode of interaction of DNA polymerase epsilon with proliferating cell nuclear antigen in primer binding and DNA synthesis (Articolo in rivista) (Prodotto della ricerca)
- Structural determinants of HIV-1 reverse transcriptase stereoselectivity towards (beta)-L-deoxy- and dideoxy pyrimidine nucleoside triphosphates: Molecular basis for the combination of L-dideoxynucleoside analogs with nonnucleoside inhibitors in anti HIV chemotherapy. (Articolo in rivista) (Prodotto della ricerca)
- 2-(Alkyl/aryl)amino-6-benzylpyrimidin-4(3H)-ones as inhibitors of wild-type and mutant HIV-1: enantioselectivity studies (Articolo in rivista) (Prodotto della ricerca)
- Human DNA Polymerase beta, but Not lambda, Can Bypass a 2-Deoxyribonolactone Lesion Together with Proliferating Cell Nuclear Antigen (Articolo in rivista) (Prodotto della ricerca)
- Tyrosine kinases as essential cellular cofactors and potential therapeutic targets for human immunodeficiency virus infection (Articolo in rivista) (Prodotto della ricerca)
- Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors (Articolo in rivista) (Prodotto della ricerca)
- Alfred Russel Wallace, l'altro uomo dell'evoluzione (Contributo in volume (capitolo o saggio)) (Prodotto della ricerca)
- N2-Phenyl-9-(hydroxyalkyl)guanines and related compounds are substrates for Herpes simplex virus thymidine kinases (Articolo in rivista) (Prodotto della ricerca)
- Synthesis, biological activity, and ADME properties of novel S-DABOs/N-DABOs as HIV reverse transcriptase inhibitors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The power of enzyme kinetics in the drug development process (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- New in silico and conventional in vitro approaches to advance HIV drug discovery and design (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis and biological evaluation of novel quinoxalinylethylpyridylthioureas as potent antiviral agents (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: Further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Mutant DNA polymerase delta from thermosensitive Schizosaccharomyces pombe strains display reduced stimulation by proliferating cell nuclear antigen (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- DNA elongation by the human DNA polymerase ? polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Microwave-assisted synthesis and biological evaluation of novel uracil derivatives inhibiting human thymidine phosphorylase. (Articolo in rivista) (Prodotto della ricerca)
- DNA polymerase lambda from calf thymus preferentially replicates damaged DNA. (Articolo in rivista) (Prodotto della ricerca)
- Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis. (Articolo in rivista) (Prodotto della ricerca)
- Occhio ai virus (Monografia o trattato scientifico) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1401)
- 8-oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSalpha. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases beta and lambda. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. A structure-activity relationship investigation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 5-Alkyl-2-alkylamino-6-(2,6-difluorophenylalkyl)-3,4-dihydropyrimidin-4(3H)-ones, a new series of potent, broad-spectrum non-nucleoside reverse transcriptase inhibitors belonging to the DABO family. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Human cytomegalovirus UL130 protein promotes endothelial cell infection through a producer cell modification of the virion. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- What makes Y family Pols potential candidates for molecular targeted therapies and novel biotechnological applications (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Alfred Russel Wallace, evoluzionista e gentiluomo (Comunicazione a convegno) (Prodotto della ricerca)
- Chi ha paura degli OGM? (Comunicazione a convegno) (Prodotto della ricerca)
- Darwin-Wallace: storia di un gentlemen agreement (Comunicazione a convegno) (Prodotto della ricerca)
- Alfred Wallace: l'altro uomo dell'evoluzione (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Roles of the human proteins PCNA, RP-A and Fen-1 in avoiding functional redundance between human DNA polymerases b and l in genomic stability safeguarding. (Comunicazione a convegno) (Prodotto della ricerca)
- Loss of telomere length homeostasis in telomerase immortalized human fibroblasts. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Q145M, a novel HIV-1 reverse transcriptase mutation conferring resistance to nucleoside and non-nucleoside reverse transcriptase inhibitors (Articolo in rivista) (Prodotto della ricerca)
- Inhibitors of human immunodeficiency virus-1 replication targeting the human dead-box polypeptide 3 (DDX3) RNA helicase (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Photoreactive DNA probes as a tool for studying the translesion synthesis system in mammalian cell extracts (Articolo in rivista) (Prodotto della ricerca)
- Current state-of-the-art in preclinical and clinical development of novel non-nucleoside HIV-1 reverse transcriptase inhibitors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Tyrosine Kinase inhibitors active against a wide panel of tumor cell lines. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Repair DNA polymerases as anticancer drug targets (Abstract/Comunicazione in rivista) (Prodotto della ricerca)
- HCV-targeted antivirals: Current status and future challenges (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Arylthiopyrrole (ATP) Derivatives as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Diketo hexenoic acid (DKHA) derivatives: the first class of selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases endowed with cytotoxic effect against leukemic cells. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Novel inhibitors of human purine nucleoside phosphorylase to control aberrant T-cell proliferation (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Expression, characterization of human DDX3 protein and construction of mutants. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Natural resistance to HIV infection: role of APOBEC. (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Pyrazolo[3,4-d]pyrimidine prodrugs: Strategic optimization of the aqueous solubility of dual Src/Abl inhibitors (Articolo in rivista) (Prodotto della ricerca)
- Auxiliary proteins PCNA, RP-A and 9-1-1 together with Fen-1 avoid functional redundance between human DNA polymerases beta and lambda in promoting genomic integrity (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- The goods and bads of DNA polymerases ? and ? actions on CAG repeats and telomeric DNA sequences (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- La proteina Vif del virus HIV-1 e un fattore accessorio per la trascrittasi inversa (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Role of the HIV-1 auxiliary protein Vif in the retrotranscription process (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Super-telomeres in transformed human fibroblasts (Articolo in rivista) (Prodotto della ricerca)
- ALFRED RUSSEL WALLACE: SELEZIONE NATURALE... E OLTRE (Articolo in rivista) (Prodotto della ricerca)
- Due atei, un prete e un agnostico. Pranzo a casa Darwin (Monografia o trattato scientifico) (Prodotto della ricerca)
- Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant (Articolo in rivista) (Prodotto della ricerca)
- DNA polymerase delta-interacting protein 2 is a processivity factor for DNA polymerase lambda during 8-oxo-7,8-dihydroguanine bypass. (Articolo in rivista) (Prodotto della ricerca)
- New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: Discovery, characterization, and crystal structure in complex with the target (Articolo in rivista) (Prodotto della ricerca)
- Identification of Hck Inhibitors As Hits for the Development of Antileukemia and Anti-HIV Agents (Articolo in rivista) (Prodotto della ricerca)
- Final Report FP6 EU Project Targeting Replication and Integration of HIV-TRIoH (Rapporti progetti di ricerca) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1714)
- Final Report IV National AIDS Program: Project 30D.72 (Rapporti progetti di ricerca) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1714)
- Resistance to Nevirapine of HIV-1 reverse transcriptase mutants: Loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Studio delle farmaco-resistenze crociate della RT di HIV-1 a inibitori nucleosidici e non-nucleosidici e sviluppo di nuovi analoghi L-nucleosidici anti-HIV a bassa citotossicità (Rapporti progetti di ricerca) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1714)
- New targets and new drugs: from in silico planning to in vivo testing (Articolo in rivista) (Prodotto della ricerca)
- New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors (Articolo in rivista) (Prodotto della ricerca)
- Microhomology-mediated DNA strand annealing and elongation by human DNA polymerases ? and ? on normal and repetitive DNA sequences (Articolo in rivista) (Prodotto della ricerca)
- AIDS: la verità negata (Monografia o trattato scientifico) (Prodotto della ricerca)
- Clostridium difficile DNA polymerase IIIC: basis for activity of antibacterial compounds (Articolo in rivista) (Prodotto della ricerca)
- DNA polymerases: discovery, characterization and functions in cellular DNA transactions (Monografia o trattato scientifico) (Prodotto della ricerca)
- DNA polymerases and Diseases (Monografia o trattato scientifico) (Prodotto della ricerca)
- Indolylarylsulfones Carrying a Heterocyclic Tail as Very Potent and Broad Spectrum HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors (Articolo in rivista) (Prodotto della ricerca)
- Intrinsic and extrinsic determinants of DNA polymerases fidelity in normal and translesion synthesis (Contributo in volume (capitolo o saggio)) (Prodotto della ricerca)
- Indolylarylsulfones Bearing Natural and Unnatural Amino Acids. Discovery of Potent Inhibitors of HIV-1 Non-Nucleoside Wild Type and Resistant Mutant Strains Reverse Transcriptase and Coxsackie B4 Virus (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Silencing of human DNA polymerase lambda causes replication stress and is synthetically lethal with an impaired S phase checkpoint. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- L'uomo che gettò nel panico Darwin. La vita e le scoperte di Alfred Russel Wallace. (Monografia o trattato scientifico) (Prodotto della ricerca)
- Reduced Basal Transcriptional Activity of Central Nervous System-Derived HIV Type 1 Long Terminal Repeats (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Pierre-Louis Moreau de Maupertuis, Lettere filosofiche e scientifiche. Lettera sul progresso delle scienze. (Curatela) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1501)
- Exploring the chemical space around the privileged pyrazolo[3,4-d] pyrimidine scaffold: Toward novel allosteric inhibitors of T315I-mutated Abl (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Exploring the Role of 2-Chloro-6-fluoro Substitution in 2-Alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: Effects in HIV-1-Infected Cells and in HIV-1 Reverse Transcriptase Enzymes (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Alexander von Humboldt. Schizzo biografico \"dal vivo\" (Monografia o trattato scientifico) (Prodotto della ricerca)
- New indolylarylsulfones as highly potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors (Articolo in rivista) (Prodotto della ricerca)
- Maupertuis: the 'Old Synthesis' (Articolo in rivista) (Prodotto della ricerca)
- DNA polymerases as anticancer drug targets (Comunicazione a convegno) (Prodotto della ricerca)
- 6-Vinyl pyrimidine and pyrimidinone derivatives and the use thereof. (Brevetto) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1601)
- Il sogno febbricitante di Alfred Russel Wallace (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- L'uomo che gettò nel panico Darwin (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Il monaco e le sue leggi (Altro prodotto) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1731)
- Non solo Darwin (Altro prodotto) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1731)
- Selective interaction of the human immunodeficiency virus type 1 reverse transcriptase nonnucleoside inhibitor efavirenz and its thio-substituted analog with different enzyme-substrate complexes (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Electron microscopic analysis reveals that replication factor C is sequestered by single-stranded DNA (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Solid phase synthesis of 2,6-disubstituted-4(3H)-pyrimidinones targeting HIV-1 reverse transcriptase (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- L'arcipelago malese di Wallace: quando la ricerca diventa letteratura (Rassegna e recensione) (Prodotto della ricerca)
- Genesi di un mito: Alexander von Humboldt (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants. (Articolo in rivista) (Prodotto della ricerca)
- Overcoming the Drug Resistance Problem with Second-Generation Tyrosine Kinase Inhibitors: From Enzymology to Structural Models. (Articolo in rivista) (Prodotto della ricerca)
- Targeting the Human DEAD-Box Polypeptide 3 (DDX3) RNA Helicase as a Novel Strategy to Inhibit Viral Replication. (Articolo in rivista) (Prodotto della ricerca)
- A Motif Unique to the Human Dead-Box Protein DDX3 Is Important for Nucleic Acid Binding, ATP Hydrolysis, RNA/DNA Unwinding and HIV-1 Replication. (Articolo in rivista) (Prodotto della ricerca)
- Wallace e Darwin tra fama e pettegolezzo (Rassegna e recensione) (Prodotto della ricerca)
- Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4-d]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study. (Articolo in rivista) (Prodotto della ricerca)
- Il Viaggio di Alexander von Humboldt (Rassegna e recensione) (Prodotto della ricerca)
- N2-Benzyloxycarbonylguan-9-yl Acetic Acid Derivatives as HIV-1 Reverse Transcriptase Non-Nucleoside Inhibitors with Decreased Loss of Potency Against Common Drug-Resistance Mutations. (Articolo in rivista) (Prodotto della ricerca)
- Molecular Characterization of c-Abl/c-Src Kinase Inhibitors Targeted against Murine Tumour Progenitor Cells that Express Stem Cell Markers. (Articolo in rivista) (Prodotto della ricerca)
- Oxidative DNA Damage Bypass in Arabidopsis thaliana Requires DNA Polymerase {lambda} and Proliferating Cell Nuclear Antigen 2. (Articolo in rivista) (Prodotto della ricerca)
- Human Immunodeficiency Virus (HIV-1) Auxiliary Protein Vif and Cellular APOBEC Deaminases: Their Roles Unveiled? (Articolo in rivista) (Prodotto della ricerca)
- Alfred Russel Wallace: naturalista e gentiluomo (Comunicazione a convegno) (Prodotto della ricerca)
- Beethoven, Schopenhauer, Humboldt, ovvero l'unità dell'Essere nell'intuizione artistica, nella speculazione filosofica e nella ricerca scientifica. (Articolo in rivista) (Prodotto della ricerca)
- Un lungo percorso. La vita e l'opera di Alfred Russel Wallace (Comunicazione a convegno) (Prodotto della ricerca)
- The 2009 Influenza Pandemic: Promising Lessons for Antiviral Therapy For Future Outbreaks. (Articolo in rivista) (Prodotto della ricerca)
- Effect of combinations of antiviral drugs on herpes simplex encephalitis. (Articolo in rivista) (Prodotto della ricerca)
- DNA replication and repair bypass machines. (Articolo in rivista) (Prodotto della ricerca)
- Evoluzionismo darwininano: il braccio violento della «Volontà». (Articolo in rivista) (Prodotto della ricerca)
- Exploiting the nucleotide substrate specificity of repair DNA polymerases to develop novel anticancer agents. (Articolo in rivista) (Prodotto della ricerca)
- N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a Scaffold for the Synthesis of Inhibitors of Bcr-Abl. (Articolo in rivista) (Prodotto della ricerca)
- Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents. (Articolo in rivista) (Prodotto della ricerca)
- The resveratrol analogue 4,4'-dihydroxy-trans-stilbene inhibits cell proliferation with higher efficiency but different mechanism from resveratrol. (Articolo in rivista) (Prodotto della ricerca)
- 3D QSAR Models Built on Structure-Based Alignments of Abl Tyrosine Kinase Inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Inhibition of Subgenomic Hepatitis C Virus RNA Replication by Acridone Derivatives: Identification of an NS3 Helicase Inhibitor. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Diarylpyrimidine-Dihydrobenzyloxopyrimidine Hybrids: New, Wide-Spectrum Anti-HIV-1 Agents Active at (Sub)-Nanomolar Level. (Articolo in rivista) (Prodotto della ricerca)
- Wallace e Darwin alla luce dei fatti (Rassegna e recensione) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1108)
- Inhibition of Bcr-Abl Phosphorylation and Induction of Apoptosis by Pyrazolo[3,4-d]pyrimidines in Human Leukemia Cells. (Articolo in rivista) (Prodotto della ricerca)
- Arylthiopyrrole (AThP) Derivatives as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: Synthesis, Structure-Activity Relationships, and Docking Studies (Part 2). (Articolo in rivista) (Prodotto della ricerca)
- Structure-based pharmacophore identification of new chemical scaffolds as non-nucleoside reverse transcriptase inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Final Report FP5 EU Project DNA replication and Biotechnology (Rapporti progetti di ricerca) (Prodotto della ricerca)
- Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- L'evoluzionismo prima di Darwin (Rassegna e recensione) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1108)
- DNA polymerases beta and lambda bypass thymine glycol in gapped DNA structures. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- DNA polymerases and cancer (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Genetic divergence of influenza A NS1 gene in pandemic 2009 H1N1 isolates with respect to H1N1 and H3N2 isolates from previous seasonal epidemics. (Articolo in rivista) (Prodotto della ricerca)
- Design and synthesis of thiadiazoles and thiazoles targeting the Bcr-Abl T315I mutant: from docking false positives to ATP-noncompetitive inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- 2,3-Dihydro-1,2-Diphenyl-substituted 4H-Pyridinone Derivatives as New Anti Flaviviridae Inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Alfred Russel Wallace, l'evoluzionista gentiluomo (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- A new proofreading mechanism for lesion bypass by DNA polymerase-lambda (Articolo in rivista) (Prodotto della ricerca)
- Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase. (Articolo in rivista) (Prodotto della ricerca)
- Darwin: pensieri sulla religione (Rassegna e recensione) (Prodotto della ricerca)
- Felice di conoscerla, signora Darwin... (Rassegna e recensione) (Prodotto della ricerca)
- Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Human terminal deoxynucleotidyl transferases as novel targets for anticancer chemotherapy. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Filosofia zoppa, scienza cieca (Rassegna e recensione) (Prodotto della ricerca)
- Storie di erbe e malattie (Rassegna e recensione) (Prodotto della ricerca)
- High potency of indolyl aryl sulfone nonnucleoside inhibitors towards drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutants is due to selective targeting of different mechanistic forms of the enzyme. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Clostridium difficile DNA polymerase IIIC: cloning, purification and analysis of specific inhibitors. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Non-nucleoside HIV-1 reverse transcriptase inhibitors di-halo-indolyl aryl sulfones achieve tight binding to drug-resistant mutants by targeting the enzyme-substrate complex. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- NNRTI-selected mutations at codon 190 of human immunodeficiency virus type 1 reverse transcriptase decrease susceptibility to stavudine and zidovudine. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Pharmacophore modeling and molecular docking led to the discovery of inhibitors of human immunodeficiency virus-1 replication targeting the human cellular aspartic acid-glutamic acid-alanine-aspartic acid box polypeptide 3. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Substrate-Induced Stable Enzyme-Inhibitor Complex Formation Allows Tight Binding of Novel 2-Aminopyrimidin-4(3H)-ones to Drug-Resistant HIV-1 Reverse Transcriptase Mutants. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The effects of prolonged treatment with zidovudine, lamivudine, and abacavir on a T-lymphoblastoid cell line. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Synthesis and Biological Properties of Novel 2-Aminopyrimidin-4(3H)-ones Highly Potent against HIV-1 Mutant Strains. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Adhesion of a two-step etch-and-rinse adhesive on collagen-depleted dentin. (Articolo in rivista) (Prodotto della ricerca)
- Slow binding-tight binding interaction between benzimidazol-2-one inhibitors and HIV-1 reverse transcriptase containing the lysine 103 to asparagine mutation. (Articolo in rivista) (Prodotto della ricerca)
- Targeting host-pathogen interactions in viral infections as a novel therapeutic strategy: lessons from cancer research (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- L'uomo che gettò nel panico Darwin. La vita e le scoperte di Alfred Russel Wallace (Comunicazione a convegno) (Prodotto della ricerca)
- Design, synthesis, biological evaluation, and molecular modeling studies of TIBO-like cyclic sulfones as non-nucleoside HIV-1 reverse transcriptase inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Cloning and characterization of thymidine kinase and uridine-cytidine kinase from Entamoeba histolytica. Search for specific inhibitors (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Novel host-pathogen interactions between human proteins and NS1 of epidemic avian influenza virus (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data. (Articolo in rivista) (Prodotto della ricerca)
- Human DNA polymerase lambda binds to the front side of PCNA through a conserved HhH-motif and its binding is regulated by p21 (Comunicazione a convegno) (Prodotto della ricerca)
- DNA polymerase lambda: mechanism of frameshift generation and regulation of its terminal-transferase and polymerase activities by PCNA an (Comunicazione a convegno) (Prodotto della ricerca)
- Mutational analysis of the HIV-1 auxiliary protein Vif identifies independent domains important for the physical and functional interaction with HIV-1 reverse transcriptase. (Articolo in rivista) (Prodotto della ricerca)
- Replication protein a as a \"fidelity clamp\" for DNA polymerase alpha (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Indolylarylsulfones as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: New Cyclic Substituents at Indole-2-carboxamide. (Articolo in rivista) (Prodotto della ricerca)
- Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase. (Articolo in rivista) (Prodotto della ricerca)
- Discovery of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Competing with the Nucleotide Substrate. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Replication of 2-hydroxyadenine-containing DNA and recognition by human MutSalpha. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Thymidine kinase and uridine-cytidine kinase from Entamoeba histolytica: cloning, characterization, and search for specific inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Expanding the repertoire of DNA polymerase substrates: template-instructed incorporation of non-nucleoside triphosphate analogues by DNA polymerases beta and lambda. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Error-free bypass of 2-hydroxyadenine by human DNA polymerase lambda with Proliferating Cell Nuclear Antigen and Replication Protein A in different sequence contexts. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Identification of a Novel Pyrazolo[3,4-d]pyrimidine Able To Inhibit Cell Proliferation of a Human Osteogenic Sarcoma in Vitro and in a Xenograft Model in Mice. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Inhibitors of Adenosine kinase: perspective for the control of intercellular signalling during tissue stress and trauma (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Human replication protein A can suppress the intrinsic in vitro mutator phenotype of human DNA polymerase lambda. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Simplified analogues of immucillin-G retain potent human purine nucleoside phosphorylase inhibitory activity. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation. (Articolo in rivista) (Prodotto della ricerca)
- A multidisciplinary approach for the identification of novel HIV-1 non-nucleoside reverse transcriptase inhibitors: S-DABOCs and DAVPs. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Mechanism of interaction of novel indolylarylsulfone derivatives with K103N and Y181I mutant HIV-1 reverse transcriptase in complex with its substrates. (Articolo in rivista) (Prodotto della ricerca)
- Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The PDZ-Ligand and Src-Homology Type 3 Domains of Epidemic Avian Influenza Virus NS1 Protein Modulate Human Src Kinase Activity during Viral Infection. (Articolo in rivista) (Prodotto della ricerca)
- Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Slow-, Tight-Binding HIV-1 Reverse Transcriptase Non-Nucleoside Inhibitors Highly Active against Drug-Resistant Mutants. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The balance between the rates of incorporation and pyrophosphorolytic removal influences the HIV-1 reverse transcriptase bypass of an abasic site with deoxy-, dideoxy-, and ribonucleotides. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- APOBEC deaminases as cellular antiviral factors: a novel natural host defense mechanism. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Modulation of the (in)fidelity of DNA polymerase lamda by PCNA and RP-A (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Investigation of novel lipid-functionalized PNA monomers as potential HIV-1 non-nucleoside reverse transcriptase and/or integrase inhibitors. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Effetti di differenti mutazioni nella RT di HIV-1 sulla fitness virale e sulla resistenza multipla a inibitori nucleosidici e non-nucleosidici (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- DNA polymerase lamda: mechanism of frameshift generation and regulation of its terminal-transferase and polymerase activities by PCNA and RP-A (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- 8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Inhibition of Herpes simplex virus thymidine kinases by 2-Phenylamino-6-oxopurines and related compounds: Structure-Activity Relationships and antiherpetic activity in vivo. (Articolo in rivista) (Prodotto della ricerca)
- Two-step genetic screening of thrombophilia by pyrosequencing (Articolo in rivista) (Prodotto della ricerca)
- L'uomo è morto, viva l'uomo! (Articolo in rivista) (Prodotto della ricerca)
- Diketo hexenoic acid derivatives are novel selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases, with potent cytotoxic effect against leukemic cells. (Articolo in rivista) (Prodotto della ricerca)
- Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhib (Articolo in rivista) (Prodotto della ricerca)
- Human DEAD-box ATPase DDX3 shows a relaxed nucleoside substrate specificity. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- DNA polymerases and mutagenesis in human cancers. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Parallel solution-phase and microwave-assisted synthesis of new S-DABO derivatives endowed with subnanomolar anti-HIV-1 activity. (Articolo in rivista) (Prodotto della ricerca)
- The block of DNA polymerase delta strand displacement activity by an abasic site can be rescued by the concerted action of DNA polymerase beta and flap endonuclease 1. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity. (Articolo in rivista) (Prodotto della ricerca)
- Towards novel S-DABOC inhibitors: Synthesis, biological investigation, and molecular modeling studies. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Replication protein A and proliferating cell nuclear antigen coordinate DNA polymerase selection in 8-oxo-guanine repair. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT. (Articolo in rivista) (Prodotto della ricerca)
- The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins. (Articolo in rivista) (Prodotto della ricerca)
- Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants. (Articolo in rivista) (Prodotto della ricerca)
- AKAP149 binds to HIV-1 reverse transcriptase and is involved in the reverse transcription. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Parallel solution-phase synthesis of 4-dialkylamino-2-methylsulfonyl-6-vinylpyrimidines. (Articolo in rivista) (Prodotto della ricerca)
- DNA polymerase lambda specifically bridges and extends DNA ends containing microhomoloy regions (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Biochemical Approach of PCNA1 and PCNA2 proteins interaction with DNA pol lambda of Arabidopsis thaliana (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Biochemical Approach of PCNA1 and PCNA2 proteins interaction with DNA pol lambda of Arabidopsis thaliana (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- DNA polymerase lambda specifically bridges and extends DNA ends containing microhomoloy regions (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Inhibitors of C. difficile DNA polymerase IIIC mechanism, antimicrobial, and antiCdiff activity in vivo. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Dihydro-alkylthio-benzyl-oxopyrimidines as inhibitors of reverse transcriptase: synthesis and rationalization of the biological data on both wild-type enzyme and relevant clinical mutants. (Articolo in rivista) (Prodotto della ricerca)
- Indolyl aryl sulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: role of two halogen atoms at the indole ring in developing new analogues with improved antiviral activity. (Articolo in rivista) (Prodotto della ricerca)
- Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains. (Articolo in rivista) (Prodotto della ricerca)
- Identificazione di nuovi target e di nuove molecole antitumorali e antivirali (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Two birds with a stone: from single- to multi-target drugs in cancer therapy (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Una cura per l'AIDS: illusioni, certezze e nuove speranze (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Indolyl aryl sulphones as HIV-1 non-nucleoside reverse transcriptase inhibitors: synthesis, biological evaluation and binding mode studies of new derivatives at indole-2-carboxamide. (Articolo in rivista) (Prodotto della ricerca)
- A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Codice
- Anno di chiusura previsto
- 2014-01-01T00:00:00+01:00 (literal)
- Istituto esecutore
- Primo anno di attività
- 2005-01-01T00:00:00+01:00 (literal)
- Abstract
- Tra le emergenze sanitare figurano malattie infettive come malaria, AIDS ed epatite virale.A fronte di ciò, appare evidente la limitatezza degli strumenti diagnostici/terapeutici a nostra disposizione. Di qui la necessità di: comprendere i meccanismi patogenetici a livello molecolare; sviluppare strategie innovative per il controllo farmacologico delle malattie. La presente Proposta di Commessa si sviluppa entro questo contesto generale.
Attualmente sono in corso i seguenti progetti:
- Caratterizzazione del ruolo funzionale delle DNA pol nel mantenimento della stabilità dell'informazione genetica
- Studio di enzimi del metabolismo nucleotidico in virus (HSV, CMV, SHVB), protozoi e cellule umane
-Ideazione e studio di analoghi nucleosidici, non-nucleosidici e nucleotidici con attività antinepolastica (tirosine chinasi), antiprotozoaria (E. histolytica), e antivirale (virus HIV, HCV, CMV, HSV, BV).
- Meccanismi di attivazione di analoghi nucleosidici.
- Meccanismi di resistenza farmacologica della RT di HIV.
-Studio relazioni ospite/patogeno nell'infezione di HIV e del virus dell'influenza
Studio dell'espressione di proteine chinasi in fibroblasti trasformati. (literal)
- Nome
- Sviluppo e meccanismo d'azione di analoghi nucleotidici e nucleosidici come composti antiproliferativi e antivirali : nuovi composti e nuovi bersagli per la terapia (literal)
- Descrizione
- Modulo di
- Gestore
Incoming links:
- Istituto esecutore di
- Gestore di
- Modulo
- Descrizione di
- Prodotto di
- Inhibition of Herpes simplex virus thymidine kinases by 2-Phenylamino-6-oxopurines and related compounds: Structure-Activity Relationships and antiherpetic activity in vivo. (Articolo in rivista) (Prodotto della ricerca)
- Two-step genetic screening of thrombophilia by pyrosequencing (Articolo in rivista) (Prodotto della ricerca)
- L'uomo è morto, viva l'uomo! (Articolo in rivista) (Prodotto della ricerca)
- Diketo hexenoic acid derivatives are novel selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases, with potent cytotoxic effect against leukemic cells. (Articolo in rivista) (Prodotto della ricerca)
- Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhib (Articolo in rivista) (Prodotto della ricerca)
- Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT. (Articolo in rivista) (Prodotto della ricerca)
- The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins. (Articolo in rivista) (Prodotto della ricerca)
- Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants. (Articolo in rivista) (Prodotto della ricerca)
- Parallel solution-phase and microwave-assisted synthesis of new S-DABO derivatives endowed with subnanomolar anti-HIV-1 activity. (Articolo in rivista) (Prodotto della ricerca)
- Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity. (Articolo in rivista) (Prodotto della ricerca)
- Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Human replication protein A can suppress the intrinsic in vitro mutator phenotype of human DNA polymerase lambda. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Simplified analogues of immucillin-G retain potent human purine nucleoside phosphorylase inhibitory activity. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Identification of a Novel Pyrazolo[3,4-d]pyrimidine Able To Inhibit Cell Proliferation of a Human Osteogenic Sarcoma in Vitro and in a Xenograft Model in Mice. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Discovery of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Competing with the Nucleotide Substrate. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Replication of 2-hydroxyadenine-containing DNA and recognition by human MutSalpha. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Expanding the repertoire of DNA polymerase substrates: template-instructed incorporation of non-nucleoside triphosphate analogues by DNA polymerases beta and lambda. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Error-free bypass of 2-hydroxyadenine by human DNA polymerase lambda with Proliferating Cell Nuclear Antigen and Replication Protein A in different sequence contexts. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Replication protein a as a \"fidelity clamp\" for DNA polymerase alpha (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The balance between the rates of incorporation and pyrophosphorolytic removal influences the HIV-1 reverse transcriptase bypass of an abasic site with deoxy-, dideoxy-, and ribonucleotides. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Investigation of novel lipid-functionalized PNA monomers as potential HIV-1 non-nucleoside reverse transcriptase and/or integrase inhibitors. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- A multidisciplinary approach for the identification of novel HIV-1 non-nucleoside reverse transcriptase inhibitors: S-DABOCs and DAVPs. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Substrate-Induced Stable Enzyme-Inhibitor Complex Formation Allows Tight Binding of Novel 2-Aminopyrimidin-4(3H)-ones to Drug-Resistant HIV-1 Reverse Transcriptase Mutants. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Pharmacophore modeling and molecular docking led to the discovery of inhibitors of human immunodeficiency virus-1 replication targeting the human cellular aspartic acid-glutamic acid-alanine-aspartic acid box polypeptide 3. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Non-nucleoside HIV-1 reverse transcriptase inhibitors di-halo-indolyl aryl sulfones achieve tight binding to drug-resistant mutants by targeting the enzyme-substrate complex. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Mutational analysis of the HIV-1 auxiliary protein Vif identifies independent domains important for the physical and functional interaction with HIV-1 reverse transcriptase. (Articolo in rivista) (Prodotto della ricerca)
- Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data. (Articolo in rivista) (Prodotto della ricerca)
- Adhesion of a two-step etch-and-rinse adhesive on collagen-depleted dentin. (Articolo in rivista) (Prodotto della ricerca)
- Slow binding-tight binding interaction between benzimidazol-2-one inhibitors and HIV-1 reverse transcriptase containing the lysine 103 to asparagine mutation. (Articolo in rivista) (Prodotto della ricerca)
- Genetic divergence of influenza A NS1 gene in pandemic 2009 H1N1 isolates with respect to H1N1 and H3N2 isolates from previous seasonal epidemics. (Articolo in rivista) (Prodotto della ricerca)
- Design and synthesis of thiadiazoles and thiazoles targeting the Bcr-Abl T315I mutant: from docking false positives to ATP-noncompetitive inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- 2,3-Dihydro-1,2-Diphenyl-substituted 4H-Pyridinone Derivatives as New Anti Flaviviridae Inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Inhibition of Bcr-Abl Phosphorylation and Induction of Apoptosis by Pyrazolo[3,4-d]pyrimidines in Human Leukemia Cells. (Articolo in rivista) (Prodotto della ricerca)
- Arylthiopyrrole (AThP) Derivatives as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: Synthesis, Structure-Activity Relationships, and Docking Studies (Part 2). (Articolo in rivista) (Prodotto della ricerca)
- Structure-based pharmacophore identification of new chemical scaffolds as non-nucleoside reverse transcriptase inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Diarylpyrimidine-Dihydrobenzyloxopyrimidine Hybrids: New, Wide-Spectrum Anti-HIV-1 Agents Active at (Sub)-Nanomolar Level. (Articolo in rivista) (Prodotto della ricerca)
- Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- A new proofreading mechanism for lesion bypass by DNA polymerase-lambda (Articolo in rivista) (Prodotto della ricerca)
- Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase. (Articolo in rivista) (Prodotto della ricerca)
- DNA polymerase lambda from calf thymus preferentially replicates damaged DNA. (Articolo in rivista) (Prodotto della ricerca)
- Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis. (Articolo in rivista) (Prodotto della ricerca)
- Microwave-assisted synthesis and biological evaluation of novel uracil derivatives inhibiting human thymidine phosphorylase. (Articolo in rivista) (Prodotto della ricerca)
- 8-oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSalpha. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases beta and lambda. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. A structure-activity relationship investigation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 5-Alkyl-2-alkylamino-6-(2,6-difluorophenylalkyl)-3,4-dihydropyrimidin-4(3H)-ones, a new series of potent, broad-spectrum non-nucleoside reverse transcriptase inhibitors belonging to the DABO family. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Human cytomegalovirus UL130 protein promotes endothelial cell infection through a producer cell modification of the virion. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- High potency of indolyl aryl sulfone nonnucleoside inhibitors towards drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutants is due to selective targeting of different mechanistic forms of the enzyme. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Human terminal deoxynucleotidyl transferases as novel targets for anticancer chemotherapy. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The effects of prolonged treatment with zidovudine, lamivudine, and abacavir on a T-lymphoblastoid cell line. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Synthesis and Biological Properties of Novel 2-Aminopyrimidin-4(3H)-ones Highly Potent against HIV-1 Mutant Strains. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- NNRTI-selected mutations at codon 190 of human immunodeficiency virus type 1 reverse transcriptase decrease susceptibility to stavudine and zidovudine. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 3D QSAR Models Built on Structure-Based Alignments of Abl Tyrosine Kinase Inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Inhibition of Subgenomic Hepatitis C Virus RNA Replication by Acridone Derivatives: Identification of an NS3 Helicase Inhibitor. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents. (Articolo in rivista) (Prodotto della ricerca)
- The resveratrol analogue 4,4'-dihydroxy-trans-stilbene inhibits cell proliferation with higher efficiency but different mechanism from resveratrol. (Articolo in rivista) (Prodotto della ricerca)
- Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- DNA polymerases beta and lambda bypass thymine glycol in gapped DNA structures. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- N2-Benzyloxycarbonylguan-9-yl Acetic Acid Derivatives as HIV-1 Reverse Transcriptase Non-Nucleoside Inhibitors with Decreased Loss of Potency Against Common Drug-Resistance Mutations. (Articolo in rivista) (Prodotto della ricerca)
- Molecular Characterization of c-Abl/c-Src Kinase Inhibitors Targeted against Murine Tumour Progenitor Cells that Express Stem Cell Markers. (Articolo in rivista) (Prodotto della ricerca)
- Oxidative DNA Damage Bypass in Arabidopsis thaliana Requires DNA Polymerase {lambda} and Proliferating Cell Nuclear Antigen 2. (Articolo in rivista) (Prodotto della ricerca)
- Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4-d]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study. (Articolo in rivista) (Prodotto della ricerca)
- Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants. (Articolo in rivista) (Prodotto della ricerca)
- Overcoming the Drug Resistance Problem with Second-Generation Tyrosine Kinase Inhibitors: From Enzymology to Structural Models. (Articolo in rivista) (Prodotto della ricerca)
- Targeting the Human DEAD-Box Polypeptide 3 (DDX3) RNA Helicase as a Novel Strategy to Inhibit Viral Replication. (Articolo in rivista) (Prodotto della ricerca)
- A Motif Unique to the Human Dead-Box Protein DDX3 Is Important for Nucleic Acid Binding, ATP Hydrolysis, RNA/DNA Unwinding and HIV-1 Replication. (Articolo in rivista) (Prodotto della ricerca)
- DNA replication and repair bypass machines. (Articolo in rivista) (Prodotto della ricerca)
- Exploiting the nucleotide substrate specificity of repair DNA polymerases to develop novel anticancer agents. (Articolo in rivista) (Prodotto della ricerca)
- N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a Scaffold for the Synthesis of Inhibitors of Bcr-Abl. (Articolo in rivista) (Prodotto della ricerca)
- The 2009 Influenza Pandemic: Promising Lessons for Antiviral Therapy For Future Outbreaks. (Articolo in rivista) (Prodotto della ricerca)
- Enantioselectivity of ribonucleotide reductase: a first study using stereoisomers of pyrimidine 2'-azido-2'-deoxynucleosides. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Parallel solution-phase synthesis of 4-dialkylamino-2-methylsulfonyl-6-vinylpyrimidines. (Articolo in rivista) (Prodotto della ricerca)
- Indolyl aryl sulphones as HIV-1 non-nucleoside reverse transcriptase inhibitors: synthesis, biological evaluation and binding mode studies of new derivatives at indole-2-carboxamide. (Articolo in rivista) (Prodotto della ricerca)
- A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Indolyl aryl sulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: role of two halogen atoms at the indole ring in developing new analogues with improved antiviral activity. (Articolo in rivista) (Prodotto della ricerca)
- Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains. (Articolo in rivista) (Prodotto della ricerca)
- Dihydro-alkylthio-benzyl-oxopyrimidines as inhibitors of reverse transcriptase: synthesis and rationalization of the biological data on both wild-type enzyme and relevant clinical mutants. (Articolo in rivista) (Prodotto della ricerca)
- Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Human DEAD-box ATPase DDX3 shows a relaxed nucleoside substrate specificity. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- AKAP149 binds to HIV-1 reverse transcriptase and is involved in the reverse transcription. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Replication protein A and proliferating cell nuclear antigen coordinate DNA polymerase selection in 8-oxo-guanine repair. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The block of DNA polymerase delta strand displacement activity by an abasic site can be rescued by the concerted action of DNA polymerase beta and flap endonuclease 1. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Towards novel S-DABOC inhibitors: Synthesis, biological investigation, and molecular modeling studies. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- DNA polymerases and mutagenesis in human cancers. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Thymidine kinase and uridine-cytidine kinase from Entamoeba histolytica: cloning, characterization, and search for specific inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Indolylarylsulfones as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: New Cyclic Substituents at Indole-2-carboxamide. (Articolo in rivista) (Prodotto della ricerca)
- Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase. (Articolo in rivista) (Prodotto della ricerca)
- Slow-, Tight-Binding HIV-1 Reverse Transcriptase Non-Nucleoside Inhibitors Highly Active against Drug-Resistant Mutants. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- APOBEC deaminases as cellular antiviral factors: a novel natural host defense mechanism. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation. (Articolo in rivista) (Prodotto della ricerca)
- Mechanism of interaction of novel indolylarylsulfone derivatives with K103N and Y181I mutant HIV-1 reverse transcriptase in complex with its substrates. (Articolo in rivista) (Prodotto della ricerca)
- The PDZ-Ligand and Src-Homology Type 3 Domains of Epidemic Avian Influenza Virus NS1 Protein Modulate Human Src Kinase Activity during Viral Infection. (Articolo in rivista) (Prodotto della ricerca)
- Human Immunodeficiency Virus (HIV-1) Auxiliary Protein Vif and Cellular APOBEC Deaminases: Their Roles Unveiled? (Articolo in rivista) (Prodotto della ricerca)
- Beethoven, Schopenhauer, Humboldt, ovvero l'unità dell'Essere nell'intuizione artistica, nella speculazione filosofica e nella ricerca scientifica. (Articolo in rivista) (Prodotto della ricerca)
- DNA polymerases and Diseases. (Articolo in rivista) (Prodotto della ricerca)
- Repair and translesion DNA polymerases as anticancer drug targets. (Articolo in rivista) (Prodotto della ricerca)
- Evoluzionismo darwininano: il braccio violento della «Volontà». (Articolo in rivista) (Prodotto della ricerca)
- Effect of combinations of antiviral drugs on herpes simplex encephalitis. (Articolo in rivista) (Prodotto della ricerca)
- La proteina Vif del virus HIV-1 e un fattore accessorio per la trascrittasi inversa (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Role of the HIV-1 auxiliary protein Vif in the retrotranscription process (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Novel inhibitors of human purine nucleoside phosphorylase to control aberrant T-cell proliferation (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Arylthiopyrrole (ATP) Derivatives as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Diketo hexenoic acid (DKHA) derivatives: the first class of selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases endowed with cytotoxic effect against leukemic cells. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Tyrosine Kinase inhibitors active against a wide panel of tumor cell lines. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Expression, characterization of human DDX3 protein and construction of mutants. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Natural resistance to HIV infection: role of APOBEC. (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Loss of telomere length homeostasis in telomerase immortalized human fibroblasts. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Alfred Russel Wallace, evoluzionista e gentiluomo (Comunicazione a convegno) (Prodotto della ricerca)
- Chi ha paura degli OGM? (Comunicazione a convegno) (Prodotto della ricerca)
- Darwin-Wallace: storia di un gentlemen agreement (Comunicazione a convegno) (Prodotto della ricerca)
- Alfred Wallace: l'altro uomo dell'evoluzione (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Roles of the human proteins PCNA, RP-A and Fen-1 in avoiding functional redundance between human DNA polymerases b and l in genomic stability safeguarding. (Comunicazione a convegno) (Prodotto della ricerca)
- Inhibitors of human immunodeficiency virus-1 replication targeting the human dead-box polypeptide 3 (DDX3) RNA helicase (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Inhibitors of Adenosine kinase: perspective for the control of intercellular signalling during tissue stress and trauma (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Modulation of the (in)fidelity of DNA polymerase lamda by PCNA and RP-A (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Effetti di differenti mutazioni nella RT di HIV-1 sulla fitness virale e sulla resistenza multipla a inibitori nucleosidici e non-nucleosidici (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- DNA polymerase lamda: mechanism of frameshift generation and regulation of its terminal-transferase and polymerase activities by PCNA and RP-A (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Human DNA polymerase lambda binds to the front side of PCNA through a conserved HhH-motif and its binding is regulated by p21 (Comunicazione a convegno) (Prodotto della ricerca)
- DNA polymerase lambda: mechanism of frameshift generation and regulation of its terminal-transferase and polymerase activities by PCNA an (Comunicazione a convegno) (Prodotto della ricerca)
- L'uomo che gettò nel panico Darwin. La vita e le scoperte di Alfred Russel Wallace (Comunicazione a convegno) (Prodotto della ricerca)
- Cloning and characterization of thymidine kinase and uridine-cytidine kinase from Entamoeba histolytica. Search for specific inhibitors (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Alfred Russel Wallace, l'evoluzionista gentiluomo (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- DNA polymerases and cancer (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Clostridium difficile DNA polymerase IIIC: cloning, purification and analysis of specific inhibitors. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Monitoring oxidative damage responses in Daucos carota cell lines: contribution of DNA topoisomerase I (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Mutations coferring interclass antiretroviral drug resistance and their impact on HIV-1 replicative capacity (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Simplified analogs of Immucilin-G retain potent human purine nucleoside phosphorylase inhibitory activity. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Novel NNRTIs (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Second generation PBOs show enantioselective binding to the catalytic complex of HIV-1 RT wt and drug resistant mutants. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Characterization of novel N,N-DABOs as effective tight binding non-nucleoside inhibitors of HIV-1 RT. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Novel HIV-1 NNRTIs with reduced loss of potency against common drug-resistant mutations. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Identificazione di nuovi target e di nuove molecole antitumorali e antivirali (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Two birds with a stone: from single- to multi-target drugs in cancer therapy (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Una cura per l'AIDS: illusioni, certezze e nuove speranze (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- DNA polymerase lambda specifically bridges and extends DNA ends containing microhomoloy regions (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Biochemical Approach of PCNA1 and PCNA2 proteins interaction with DNA pol lambda of Arabidopsis thaliana (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Biochemical Approach of PCNA1 and PCNA2 proteins interaction with DNA pol lambda of Arabidopsis thaliana (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- DNA polymerase lambda specifically bridges and extends DNA ends containing microhomoloy regions (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Inhibitors of C. difficile DNA polymerase IIIC mechanism, antimicrobial, and antiCdiff activity in vivo. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- L'uomo che gettò nel panico Darwin. La vita e le scoperte di Alfred Russel Wallace. (Monografia o trattato scientifico) (Prodotto della ricerca)
- DNA polymerases and Diseases (Monografia o trattato scientifico) (Prodotto della ricerca)
- Intrinsic and extrinsic determinants of DNA polymerases fidelity in normal and translesion synthesis (Contributo in volume (capitolo o saggio)) (Prodotto della ricerca)
- DNA polymerases: discovery, characterization and functions in cellular DNA transactions (Monografia o trattato scientifico) (Prodotto della ricerca)
- Final Report FP5 EU Project DNA replication and Biotechnology (Rapporti progetti di ricerca) (Prodotto della ricerca)
- Alexander von Humboldt. Schizzo biografico \"dal vivo\" (Monografia o trattato scientifico) (Prodotto della ricerca)
- 6-Vinyl pyrimidine and pyrimidinone derivatives and the use thereof. (Brevetto) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1601)
- Ruolo funzionale della proteina Vif di HIV-1 nel processo di retrotrascrizione del genoma virale (Rapporti progetti di ricerca) (Prodotto della ricerca)
- Final Report IV National AIDS Program: Project 30D.72 (Rapporti progetti di ricerca) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1714)
- Studio delle farmaco-resistenze crociate della RT di HIV-1 a inibitori nucleosidici e non-nucleosidici e sviluppo di nuovi analoghi L-nucleosidici anti-HIV a bassa citotossicità (Rapporti progetti di ricerca) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1714)
- Final Report FP6 EU Project Targeting Replication and Integration of HIV-TRIoH (Rapporti progetti di ricerca) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1714)
- Indolylarylsulfones Bearing Natural and Unnatural Amino Acids. Discovery of Potent Inhibitors of HIV-1 Non-Nucleoside Wild Type and Resistant Mutant Strains Reverse Transcriptase and Coxsackie B4 Virus (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Design, synthesis, biological evaluation, and molecular modeling studies of TIBO-like cyclic sulfones as non-nucleoside HIV-1 reverse transcriptase inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Clostridium difficile DNA polymerase IIIC: basis for activity of antibacterial compounds (Articolo in rivista) (Prodotto della ricerca)
- Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors (Articolo in rivista) (Prodotto della ricerca)
- 2-(Alkyl/aryl)amino-6-benzylpyrimidin-4(3H)-ones as inhibitors of wild-type and mutant HIV-1: enantioselectivity studies (Articolo in rivista) (Prodotto della ricerca)
- Human DNA Polymerase beta, but Not lambda, Can Bypass a 2-Deoxyribonolactone Lesion Together with Proliferating Cell Nuclear Antigen (Articolo in rivista) (Prodotto della ricerca)
- Tyrosine kinases as essential cellular cofactors and potential therapeutic targets for human immunodeficiency virus infection (Articolo in rivista) (Prodotto della ricerca)
- Due atei, un prete e un agnostico. Pranzo a casa Darwin (Monografia o trattato scientifico) (Prodotto della ricerca)
- Microhomology-mediated DNA strand annealing and elongation by human DNA polymerases ? and ? on normal and repetitive DNA sequences (Articolo in rivista) (Prodotto della ricerca)
- New targets and new drugs: from in silico planning to in vivo testing (Articolo in rivista) (Prodotto della ricerca)
- New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors (Articolo in rivista) (Prodotto della ricerca)
- Super-telomeres in transformed human fibroblasts (Articolo in rivista) (Prodotto della ricerca)
- DNA elongation by the human DNA polymerase ? polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Alfred Russel Wallace, l'altro uomo dell'evoluzione (Contributo in volume (capitolo o saggio)) (Prodotto della ricerca)
- N2-Phenyl-9-(hydroxyalkyl)guanines and related compounds are substrates for Herpes simplex virus thymidine kinases (Articolo in rivista) (Prodotto della ricerca)
- Synthesis, biological activity, and ADME properties of novel S-DABOs/N-DABOs as HIV reverse transcriptase inhibitors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The power of enzyme kinetics in the drug development process (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- New in silico and conventional in vitro approaches to advance HIV drug discovery and design (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Occhio ai virus (Monografia o trattato scientifico) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1401)
- NEW 4-SUBSTITUTED DERIVATIVES OF PYRAZOLO[3,4-d]PYRIMIDINE AND PYRROLO[2,3-d]PYRIMIDINE AND USES THEREOF (Brevetto) (Prodotto della ricerca)
- CRYSTAL STRUCTURE OF THE HIV-1 REVERSE TRANSCRIPTASE BOUND TO A NUCLEOTIDE-COMPETITIVE REVERSE TRANSCRIPTASE INHIBITOR AND THE USE THEREOF (Brevetto) (Prodotto della ricerca)
- COMPOUNDS WITH DDX3 INHIBITORY ACTIVITY AND USES THEREOF (Brevetto) (Prodotto della ricerca)
- Novel host-pathogen interactions between human proteins and NS1 of epidemic avian influenza virus (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Targeting host-pathogen interactions in viral infections as a novel therapeutic strategy: lessons from cancer research (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Selective interaction of the human immunodeficiency virus type 1 reverse transcriptase nonnucleoside inhibitor efavirenz and its thio-substituted analog with different enzyme-substrate complexes (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Electron microscopic analysis reveals that replication factor C is sequestered by single-stranded DNA (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Solid phase synthesis of 2,6-disubstituted-4(3H)-pyrimidinones targeting HIV-1 reverse transcriptase (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Silencing of human DNA polymerase lambda causes replication stress and is synthetically lethal with an impaired S phase checkpoint. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- ALFRED RUSSEL WALLACE: SELEZIONE NATURALE... E OLTRE (Articolo in rivista) (Prodotto della ricerca)
- The goods and bads of DNA polymerases ? and ? actions on CAG repeats and telomeric DNA sequences (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Auxiliary proteins PCNA, RP-A and 9-1-1 together with Fen-1 avoid functional redundance between human DNA polymerases beta and lambda in promoting genomic integrity (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Repair DNA polymerases as anticancer drug targets (Abstract/Comunicazione in rivista) (Prodotto della ricerca)
- Photoreactive DNA probes as a tool for studying the translesion synthesis system in mammalian cell extracts (Articolo in rivista) (Prodotto della ricerca)
- Non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis and biological evaluation of novel quinoxalinylethylpyridylthioureas as potent antiviral agents (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: Further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Mutant DNA polymerase delta from thermosensitive Schizosaccharomyces pombe strains display reduced stimulation by proliferating cell nuclear antigen (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- DNA polymerases as anticancer drug targets (Comunicazione a convegno) (Prodotto della ricerca)
- Current state-of-the-art in preclinical and clinical development of novel non-nucleoside HIV-1 reverse transcriptase inhibitors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Q145M, a novel HIV-1 reverse transcriptase mutation conferring resistance to nucleoside and non-nucleoside reverse transcriptase inhibitors (Articolo in rivista) (Prodotto della ricerca)
- Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3 '-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs (Articolo in rivista) (Prodotto della ricerca)
- Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides (Articolo in rivista) (Prodotto della ricerca)
- Dual mode of interaction of DNA polymerase epsilon with proliferating cell nuclear antigen in primer binding and DNA synthesis (Articolo in rivista) (Prodotto della ricerca)
- Structural determinants of HIV-1 reverse transcriptase stereoselectivity towards (beta)-L-deoxy- and dideoxy pyrimidine nucleoside triphosphates: Molecular basis for the combination of L-dideoxynucleoside analogs with nonnucleoside inhibitors in anti HIV chemotherapy. (Articolo in rivista) (Prodotto della ricerca)
- The solution structure of functionally active human proliferating cell nuclear antigen determined by small-angle neutron scattering (Articolo in rivista) (Prodotto della ricerca)
- Resistance to Nevirapine of HIV-1 reverse transcriptase mutants: Loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Cytotoxicity of alpha-dicarbonyl compounds submitted to in vitro simulated digestion process (Articolo in rivista) (Prodotto della ricerca)
- Filosofia zoppa, scienza cieca (Rassegna e recensione) (Prodotto della ricerca)
- Storie di erbe e malattie (Rassegna e recensione) (Prodotto della ricerca)
- Darwin: pensieri sulla religione (Rassegna e recensione) (Prodotto della ricerca)
- Felice di conoscerla, signora Darwin... (Rassegna e recensione) (Prodotto della ricerca)
- Alfred Russel Wallace: naturalista e gentiluomo (Comunicazione a convegno) (Prodotto della ricerca)
- Reduced Basal Transcriptional Activity of Central Nervous System-Derived HIV Type 1 Long Terminal Repeats (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- New indolylarylsulfones as highly potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors (Articolo in rivista) (Prodotto della ricerca)
- Maupertuis: the 'Old Synthesis' (Articolo in rivista) (Prodotto della ricerca)
- Exploring the Role of 2-Chloro-6-fluoro Substitution in 2-Alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: Effects in HIV-1-Infected Cells and in HIV-1 Reverse Transcriptase Enzymes (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Exploring the chemical space around the privileged pyrazolo[3,4-d] pyrimidine scaffold: Toward novel allosteric inhibitors of T315I-mutated Abl (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Pierre-Louis Moreau de Maupertuis, Lettere filosofiche e scientifiche. Lettera sul progresso delle scienze. (Curatela) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1501)
- Pyrazolo[3,4-d]pyrimidine prodrugs: Strategic optimization of the aqueous solubility of dual Src/Abl inhibitors (Articolo in rivista) (Prodotto della ricerca)
- Wallace e Darwin alla luce dei fatti (Rassegna e recensione) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1108)
- L'evoluzionismo prima di Darwin (Rassegna e recensione) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1108)
- Il Viaggio di Alexander von Humboldt (Rassegna e recensione) (Prodotto della ricerca)
- Wallace e Darwin tra fama e pettegolezzo (Rassegna e recensione) (Prodotto della ricerca)
- Un lungo percorso. La vita e l'opera di Alfred Russel Wallace (Comunicazione a convegno) (Prodotto della ricerca)
- Il monaco e le sue leggi (Altro prodotto) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1731)
- Non solo Darwin (Altro prodotto) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1731)
- HCV-targeted antivirals: Current status and future challenges (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- What makes Y family Pols potential candidates for molecular targeted therapies and novel biotechnological applications (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Indolylarylsulfones Carrying a Heterocyclic Tail as Very Potent and Broad Spectrum HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors (Articolo in rivista) (Prodotto della ricerca)
- DNA polymerase delta-interacting protein 2 is a processivity factor for DNA polymerase lambda during 8-oxo-7,8-dihydroguanine bypass. (Articolo in rivista) (Prodotto della ricerca)
- New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: Discovery, characterization, and crystal structure in complex with the target (Articolo in rivista) (Prodotto della ricerca)
- Identification of Hck Inhibitors As Hits for the Development of Antileukemia and Anti-HIV Agents (Articolo in rivista) (Prodotto della ricerca)
- Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant (Articolo in rivista) (Prodotto della ricerca)
- AIDS: la verità negata (Monografia o trattato scientifico) (Prodotto della ricerca)
- L'arcipelago malese di Wallace: quando la ricerca diventa letteratura (Rassegna e recensione) (Prodotto della ricerca)
- Genesi di un mito: Alexander von Humboldt (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- L'uomo che gettò nel panico Darwin (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Il sogno febbricitante di Alfred Russel Wallace (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d ]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma (Articolo in rivista) (Prodotto della ricerca)