Patologie del S.N. e Fattori di Crescita (ME.P02.010.001)

  • Patologie del S.N. e Fattori di Crescita (ME.P02.010.001) (literal)
  • ME.P02.010.001 (literal)
Anno di chiusura previsto
  • 2010-01-01T00:00:00+01:00 (literal)
Istituto esecutore
Primo anno di attività
  • 2005-01-01T00:00:00+01:00 (literal)
  • e investigating fields in which we are involved can be summarized in the following main research area: a) Studies on the role of Nerve Growth Factor (NGF) and Neurotrophins in brain and peripheral neuropathies. Some explorative studies on the possible therapeutic potentiality of NGF in neural pathologies are also in progress. b) Research plan focused at the understanding of the molecular mechanisms regulating the neurotoxic effects of amyloid beta and Tau peptides and also to acquire knowledge on the chemical/molecular mechanisms activated in Alzheimer's disease onset. Other studies on the cellular mechanism(s) activated in the build up of the intracellular neurofibrillary aggregates, and the extracellular deposit of senile plaques are carried out. c) Acquire knowledge on the differentiative mechanism(s) of neural stem cells in order to exploit their potential as therapeutic tool to treat neurological diseases. d) Studies on the properties of neuropeptides in some aspects of neuronal plasticity processes and extracellular signallig.e)Role of RNA induced silecing complex in plasticity processes in hippocampal neurons in order to exploit these knowledges in neurological diseases. (literal)
  • Patologie del S.N. e Fattori di Crescita (literal)
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