Istituto di biochimica delle proteine (IBP)

Type
Label
  • Istituto di biochimica delle proteine (IBP) (literal)
  • Institute of protein biochemistry (IBP) (literal)
Comment
  • The Institute of Protein Biochemistry (IBP) is part of the Department of Biomedical Sciences of the Italian National Research Council (CNR). Research at the IBP is centered on two main interconnected areas: a) protein structure-function and biocatalysis and, b) molecular cell biology and pharmacology. In the context of the first area, the focus is mainly on molecular processes that control protein stability, substrate recognition, enzyme inhibition and catalysis, with applications in biotransformation and environmental biotechnologies. The model systems range from purified proteins to bacteria and fish from extreme environments to mammalian cell lines. In addition, this basic expertise is exploited in studies of more complex issues that include the mechanisms of DNA replication, immune recognition or the generation of innovative biosensors using advanced optical and luminescence methodologies.Within the second research area, the ongoing studies address fundamental questions of cell organization in the fields of membrane transport, signalling and immunological response at the molecular and design level. The approaches include molecular, cellular, biophysical, spectroscopy and bioimaging methods. The latter include techniques such as confocal, correlative, super-resolution and Raman-based microscopy as well as electron microscopy and tomography. In addition, this expertise is used to investigate the molecular basis of cancer or rare disease development, as well as to develop screening methods for drug/target identification. These pharmacological studies are carried out in collaboration with industrial partners in the fields of cancer, rare diseases, and novel vaccine-delivery strategies. (literal)
  • The Institute of Protein Biochemistry (IBP) is part of the Department of Biomedical Sciences of the Italian National Research Council (CNR). Research at the IBP is centered on two main interconnected areas: a) protein structure-function and biocatalysis and, b) molecular cell biology and pharmacology. In the context of the first area, the focus is mainly on molecular processes that control protein stability, substrate recognition, enzyme inhibition and catalysis, with applications in biotransformation and environmental biotechnologies. The model systems range from purified proteins to bacteria and fish from extreme environments to mammalian cell lines. In addition, this basic expertise is exploited in studies of more complex issues that include the mechanisms of DNA replication, immune recognition or the generation of innovative biosensors using advanced optical and luminescence methodologies.Within the second research area, the ongoing studies address fundamental questions of cell organization in the fields of membrane transport, signalling and immunological response at the molecular and design level. The approaches include molecular, cellular, biophysical, spectroscopy and bioimaging methods. The latter include techniques such as confocal, correlative, super-resolution and Raman-based microscopy as well as electron microscopy and tomography. In addition, this expertise is used to investigate the molecular basis of cancer or rare disease development, as well as to develop screening methods for drug/target identification. These pharmacological studies are carried out in collaboration with industrial partners in the fields of cancer, rare diseases, and novel vaccine-delivery strategies. (literal)
Istituto esecutore di
Prodotto
Ha afferente
Codice
  • IBP (literal)
Nome
  • Istituto di biochimica delle proteine (IBP) (literal)
  • Institute of protein biochemistry (IBP) (literal)
Parte di
Afferisce a
Collaborazioni
  • 2003-2007 Prof. Quinxin She, Department of Biology University of Copenhagen, Copenhagen (Denmark) Theme of research: New genetic systems for the transformation of Sulfolobus species. Production of joint publications Supported by University of Naples “Federico II”, CNR and University of Copenhagen 2006-2007 Prof. John R. Engen, Department of chemistry and Chemical Biology, Northeastern University, Boston (USA) Theme of research: Mass Spectrometry of proteins. Production of joint publications Supported by CNR and University of Boston 2003-2007 Prof. Juergen Reichardt, Departments of Biochemistry and Molecular Biology and Medicine, University of Sydney, Sydney (Australia) Theme of research: Human Genetics. Supported by University of Sydney 2001-2005 Prof. H. William Detrich III, Department of Biology, Northeastern University, Boston (USA) Theme of research: Structural and functional characterization of globin genes of Antarctic fishes. Production of joint publications Supported by Italian National Programme for Antarctic Research (PNRA) and US National Science Foundation grants OPP-9815381 and OPP-0089451 2001-2003 Dr. Catherine Ozouf-Costaz , Musèum National d’Histoire Naturelle, Paris (France) Theme of research: Chromosomal localization of globin genes in Antarctic fishes. Production of joint publication Supported by Italian National Programme for Antarctic Research (PNRA) and the Musèum National d’Histoire Naturelle 2003-2007 Prof. Catherine Ozouf-Costaz, Museum National d'Histoire Naturelle, Systematique Moleculaire CNRS, Paris (France) Theme of research: Cytogenetic mapping of the Immunoglobulin heavy chain gene locus. Production of joint publications Supported by CNR and CNRS 2001-2004 Prof. Malcolm White, Centre for Biomolecular Sciences, St Andrews University, St Andrews (UK) Theme of research: DNA binding and repair proteins. Production of joint publications Supported by CNR and MIUR 2002-2004 Prof Patrick Forterre, Institut Pasteur, Paris (France) Theme of research: DNA topology. Production of joint publications Supported by CNR and MIUR 2004-2006 Prof. Marc Nadal, Institut de Génétique et Microbiologie, Universitè Paris-Sud, Orsay (France) Theme of research: Topoisomerases. Production of joint publications Supported by CNR and MIUR 2003-2007 Prof. Nancy Haigwood, Seattle Biomedical Research Institute, Seattle (USA) Theme of research: E2 display for vaccine design. Production of joint publications Supported by NIH USA 2002-2004 Svein Erik Fevolden and Jorgen Schou Christiansen, Norwegian College of Fishery Science, Tromsoe (Norway) Theme of research: Characterisation of haemoglobin of arctic fishes. Production of joint publications Supported by CNR-Polarnet 1998-2007 Prof. Joseph Lakowicz, University of Maryland at Baltimore, Baltimore (USA) Theme of research: Development of new fluoresce devices. Production of joint publications Supported by CNR and UMAB 2004-2007 Prof K.K.Turoverov, Russian Academy of Science, San Petersburg (Russia) Theme of research: Biophysical characterization of proteins. Production of joint publications Supported by NATO GRANT 2003-2007 Prof. Petr Herman, Charles University, Prague (Czech Republic) Theme of research: Biosensors development. Production of joint publications Supported by NATO GRANT 2005-2007 Prof. Ignacy Grycznyski, University of North Texas, Dallas (USA) Theme of research: Biosensors development. Production of joint publications Supported by CNR and UNTSC 2003-2007 Dr. Beniamino Barbieri, President ISS inc. Champaign, Illinois (USA) Theme of research: New optical devices. Production of joint publications Supported by CNR and ISS 2003-2007 Prof. Jung Sook Kang, Pusan National University, Miryang (South Korea) Theme of research: Gluten dertection. Production of joint publications Supported by KOSEF and Italian Ministry for Foreign Affairs 2006-2007 Prof. Piot Bojarski, University of Gdansk, Gdansk (Poland) Theme of research: Dynamics of biomolecules. Supported by CNR and University of Gdansk 2006-2007 Prof Steffen Petersen, University of Aalborg, Aalborg (Denmark) Theme of research: Biosensors. Supported by CNR and University of Aalborg 2005-2006 Prof. Maria Angelica Perillo, Università di Cordoba, Cordoba (Argentina) Theme of research: Glucose biosensors. Production of joint publications Supported by Italian Ministry for Foreign Affairs 2003 Dr. Jeroen A. Wouters, Department of Flavour, Nutrition and Ingredients, NIZO Food Research, Ede (Holland) Theme of research: Role of thermostable esterases in cheese repining. Production of joint publication 2004-2006 Prof. Louis Sarda and Prof. Henry Chaininian, Laboratoire d'Enzymologie Interfaciale et de Physiologie de la Lipolyse, UPR9025-CNRS, Marseille Cedex (France) Theme of research: Structural and kinetic characterization of members of the HSL family. Production of joint publications 2005-2006 Prof. Danny S.Tawfik, Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot (Israel) Theme of research: Characterization of a new lactonase family (PLL). Production of joint publication 2006 Prof. Andrew D. Griffiths, Institut de Science et d'Ingégnerie Supramoléculaires ISIS-ULP, Strasbourg (France) Theme of research: Directed evolution of a thermostable phosphotriesterase by in vitro compartmentalization. Supported by EMBO short term fellowship 2006-2008 Prof. Eric Chabriere, Architecture et Fonction des Macromolécules Biologiques-Unité Mixte de Recherches UMR6098 CNRS, Université de Provence Université de la Méditerranée, Marseille (France) Theme of research: Structural studies on phosphoesterases. Production of joint publications 2006-2008 Prof. Patrick Masson, Département de Toxicologie, Centre de Recherches du Service de Santé des Armées, F-38702 La Tronche Cedex (France) Theme of research: Structural studies on phosphoesterases and assays with real nerve agents. Production of joint publications 2007-2008 Prof. Yan Feng, Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun (China) Theme of research: Studies on thermostable hydrolases. Production of joint publication 2007-2008 Prof. Jorge A. Reinheimer and Prof. Carlos A. Meinardi, Instituto de Lactologia Industrial (INLAIN) - Area de Microbiologia, Facultad de Ingeniería Química, Universidad Nacional del Litoral, Santa Fe (Argentina) Theme of research: Use of thermostable esterase in cheese manufacturing and ripening. Production of joint publication Supported by CNR and CONICET 2003-2007. Prof. Gideon J. Davies, Department of Chemistry, University of York, York (UK) Theme of research: Analysis of the reaction mechanism of glycoside hydrolases. Production of joint publications Supported by CNR and University of York 2005-2007. Dr. Ikuo Matsui, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki (Japan) Theme of research: Identification of novel of glycosidases from hyperthermophiles. Production of joint publications Supported by CNR and National Institute of Advanced Industrial Science and Technology, Tsukuba 2003-2004 Prof. Stephen Denyer, Dep. of Farmacy, University of Brighton, Brighton (UK) Theme of research: Protein Adsorption and Cellular/Tissue interactions. Production of joint publications 2003-2004 Prof. Max Morandi, Dept. of Orthopaedics and Rehabilitation, Henry Ford Hospital, Detroit (USA) Theme of research: Cell differentiation on artificial matrix. 2003-2005 Prof. Salvatore Di Mauro, M.D., College Physicians & Surgeons, Columbia University, New York (USA) Theme of research: Mitochondrial Disorders. Production of joint publications Supported by Columbia University and Federation des Maladies Neuromusculaires, CHU de Nice, France. 2003-2007 M.D./Ph.D. James M. Anderson, Case Western Reserve University, Cleveland (USA) Theme of research: Materials/Biological Environment interactions. Production of joint publications Supported by CNR and Case Western Reserve University 2003-2007 Dr. Takehiko Nohmi, National Institute of Health Sciences, Tokyo (Japan) Theme of research: Biochemical characterization of translesion synthesis DNA polymerases. Production of joint publications. Supported by Japan Health Science Foundation (2001-2003) 2003-2007 Dr. Silvia Onesti, Imperial College, London (UK) Theme of research: Biochemical characterization of the archaeal MCM complex. Production of joint publications. 2003-2007 Prof. Ulrich Hubscher, University of Zurich, Zurich (Switzerland) Theme of research: Biochemical characterization of the human GINS complex. Production of joint publications Supported by the University of Zurich (2006) 2003-2007 Prof. Rudolf Ladenstein, Karolinska Institute, Stockholm (Sweden) Theme of research: Structural analysis of archaeal MCM complex. Production of joint publications Supported by the EU program REPBIOTECH (QLK–CT–2002-02071; 2003-2005) 2003-2007 Prof. H. William Detrich, Dept. of Biology Northeastern University, Boston (USA) Theme of research: Structure and function of Antarctic hemoglobins. Production of joint publications 2003-2007 Prof. Joe Eastman, Dept. of Biomedical Sciences, University of Ohio, Athens (USA) Theme of research: Biogeography of Notothenioid fish. Production of joint publications 2006-2007 Prof. Michael Marden, INSERM U779, University of Paris, Le Kremlin-Bicêtre (France ) Theme of research: Heme/ligand recognition in Antarctic globins. 2003-2007 Prof. Gaston Hui Bon Hoa, INSERM U779, University of Paris, Le Kremlin-Bicêtre (France) Theme of research: Heme/ligand recognition in Antarctic globins. 2003-2007 Prof. Guillaume Lecointre, Museum National d'Histoire Naturelle, Paris (France) Theme of research: Evolution of Antarctic notothenioid fish. Production of joint publications 2006-2007 Prof. Luc Moens, University of Antwerp, Antwerp (Belgium) Theme of research: Neuroglobin and bacterial globins. 2005-2007 Prof. Joel Friedman, Dept. of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University, New York (USA) Theme of research: Heme/ligand recognition in Antarctic hemoglobins. 2005-2007 Prof. Jack Peisach, Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University, New York (USA) Theme of research: Heme/ligand recognition in Antarctic hemoglobins. Production of joint publications 2005-2007 Dr. Michael Berenbrink, School of Biological Sciences, University of Liverpool, Liverpool (UK) Theme of research: Evolution of the Root effect in Antarctic fish. 2005-2007 Prof. Dario Estrin, INQUIMAE-CONICET, University of Buenos Aires, Buenos Aires (Argentina) Theme of research: Molecular dynamics of Antarctic globins. 2003-2007 Prof. Hans-Otto Pörtner, Alfred Wegener Institute for Polar and Marine Research, Bremerhaven (Germany) Theme of research: Thermal limits in cold-adapted fish. 2003-2007 Prof. C-H Christina Cheng, University of Illinois, Urbana (USA) Theme of research: Neuroglobin in icefish species. (literal)
Attività di formazione
  • Training is a key mission of IBP, and young researchers are always present in our laboratories for their 1st degree thesis, or for pre- and post-laurea stages. IBP has agreements with different Universities to host PhD students, and a formal ‘European Doctorate’ held jointly with the Second University of Naples is active since last year (coordinator: PG. De Berardinis), that is cofunded by H2020-MSCA. At IBP, young researchers enjoy an international environment, with colleagues from different countries, and with English as the official language for all activities. Weekly seminars with international guests, interest group meetings (immunology, computer science, cell biology, etc) are organized at IBP and are attended by young scientists. The seminars also include topics such as science politics, the presentation of Horizon 2020 programs, and the opportunities offered by MSCA and ERC. Courses on scientific publishing and communication are held by experts or by journal editors. An International Advisory Board visits IBP every second year and meets all the PhD students and postdocs. An Institute retreat is held every year. Notably, at IBP young researchers receive contracts in line with the rules of the European Charter and Code of Conduct for the Recruitment of Researchers (EC). (literal)
Http://www.cnr.it/ontology/cnr/localizzazione.owl#via
  • Via Pietro Castellino n. 111 (literal)
Cap
  • 80131 (literal)
Città
  • Napoli (literal)
Http://www.cnr.it/ontology/cnr/localizzazione.owl#provincia
  • NA (literal)
Telefono
  • 081 6132273 - 081 6132536 (literal)
Codice CDS
  • 007 (literal)
Servizi
  • IBP is organized with core facilities also available to external users.) Euro-Bioimaging facility )This facility is part of the European infrastructure Euro Bioimaging. It offers super-resolution microscopy, Raman-based microscopy, mass-imaging, electron microscopy/ tomography, correlative light/ electron microscopy, and high-throughput imaging. The facility provides training and access to external users. )This facility is also involved in technology development. Recently, the facility has developed a method to detect multiprotein complexes based on fluorescent Fab fragments for multiple long-distance FRET measurements between protein epitopes.) FACS facility (IBP-IGB))It provides support for protocol design and data analysis, phenotypic analysis of mammalian cells, cell sorting.) Chemo- and bioinformatics facility )This joint facility with Dompé (at IBP) provides support in chemoinformatics (molecular docking and dynamics, etc.) and bioinformatics (handling of large scale data and modeling). These approaches have led to joint programs with Recordati and Dompé to develop drugs for the therapy of cystic fibrosis and other conformational diseases. )Proteomics and lipidomics )A proteomics platform set up in 2007 comprises mass spectrometers equipped with nano and micro HPLC, a robotic workstation and a 2D gel system. Recently, the platform has been completed with new instruments for proteomics, lipidomics and mass-based imaging. (literal)
Competenze
  • L'IBP è, attualmente, il più grande organo del CNR ad avere come oggetto istituzionale lo studio delle proteine e degli enzimi. Questo obiettivo prioritario rappresenta il motivo unificante dell’attività scientifica dell’Istituto che, tuttavia, viene perseguito mediante una serie di sistemi sperimentali che hanno consentito, pur nell’ambito della stessa tematica, lo sviluppo di interessi culturali poliedrici, nonché di approcci metodologici differenziati. La tematica, nel suo complesso, è proiettata verso il futuro. Infatti, la determinazione delle sequenze dei genomi e la comprensione del rapporto tra la funzione e la struttura delle proteine, e la possibilità di manipolarle entrambe, rappresentano una delle sfide scientifiche del nuovo millennio. Questo approccio è in linea con la convinzione che gli sviluppi delle Biotecnologie prevedono, nel futuro, un utilizzo sempre più intensivo di proteine nelle produzioni industriali in settori quali l’alimentare, il chimico-farmaceutico, l’energetico, l’elettronico, il cosmetico, con una peculiarità molto importante, cioè quella di ridurre notevolmente l’inquinamento ambientale. L’Istituto ha sviluppato competenze per identificare e purificare proteine ed enzimi da diverse fonti per studi funzionali, cinetici e strutturali. Sono state, inoltre, pienamente acquisite le moderne metodologie molecolari che permettono di coprire l’intero percorso dall’organismo, al gene, alla proteina, nonché le apparecchiature d'avanguardia necessarie. L’attività è stata collegata alle richieste dell’industria presente sul territorio fornendo collaborazioni e consulenze. Di seguito sono brevemente riepilogate le competenze esistenti nell’IBP nei vari campi di azione: - Coltivazione e fermentazione di microrganismi estremofili (ipertermofili, termofili, psicrofili). - Genomica strutturale e funzionale dei microrganismi. - Biologia molecolare dei microrganismi. - Clonaggio ed espressione di geni di proteine in vari organismi quali E.coli, Bacillus subtilis, lieviti e Pichia pastoris. - Clonaggio ed espressione di geni di organismi termofili ad alta temperatura in Sulfolobus solfataricus. - Isolamento, purificazione e caratterizzazione di proteine ed enzimi. - Determinazione della sequenza delle proteine. - Caratterizzazione di enzimi con cinetiche allo stato stazionario e prestazionario. - Caratterizzazione biofisica delle proteine mediante tecnologie di fluorescenza, dicroismo circolare, calorimetria, spettrometria di massa. - Produzione di proteine con la tecnologia del DNA ricombinante. - Ingegneria proteica ed ottenimento di enzimi con nuove proprietà mediante mutagenesi, evoluzione molecolare e DNA shuffling. - Molecular modelling e determinazione della struttura tridimensionale di proteine in collaborazione con vari cristallografi. - Sviluppo di biosensori innovativi con tecnologie di fluorescenza e pHmetria differenziale. - Sviluppo di nuovi vaccini basati sull’utilizzo di particelle virali e spore batteriche. - Biologia molecolare dei pesci antartici. - Sviluppo di nuovi materiali per l’ingegneria tissutale. - Determinazione dei metalli nelle proteine e liquidi biologici. (literal)
Email
  • mailto:d.corda@ibp.cnr.it (literal)
  • d.corda@ibp.cnr.it (literal)
Indirizzo
  • Via Pietro Castellino n. 111 - 80131 Napoli (NA) (literal)
Direttore
Missione

  • La missione dell'IBP è centrata sullo studio dei meccanismi molecolari che regolano i processi biologici fondamentali e sul conseguente sfruttamento delle conoscenze acquisite con partners industriali. Le aree di interesse includono il rapporto struttura-funzione di proteine e biocatalisi, la biologia cellulare, l'immunologia e la farmacologia molecolare. Le applicazioni sono in campo biotecnologico con particolare attenzione alla biotrasformazione o allo sviluppo di farmaci anticancro, per malattie immuni, infiammatorie, neurologiche e rare, e di vaccini. Particolare attenzione viene poi data alla formazione di giovani ricercatori ed a programmi di divulgazione scientifica.

    L'Istituto, come il CNR, opera in regime di \"Amministrazione Trasparente\" secondo quanto indicato dal D.lgs 14 marzo 2013 n. 33 \"Riordino della disciplina riguardante gli obblighi di pubblicità, trasparenza e diffusione di informazioni da parte delle pubbliche amministrazioni\"

    (literal)
Attività di ricerca
  • The themes of research at the IBP range from protein structure-function and biocatalysis to molecular cell biology and pharmacology. In the context of the protein biocatalysis area, the focus is mainly on molecular processes that control protein stability, substrate recognition, enzyme inhibition and catalysis, with applications in biotransformation and environmental biotechnologies. The model systems range from purified proteins from microorganisms and fish from extreme environments to mammalian cell lines. In addition, this basic expertise is exploited in studies of more complex issues that include the mechanisms of DNA replication, immune recognition or the generation of innovative biosensors using advanced optical and luminescence methodologies. Within the cell biology and pharmacology area, the ongoing studies address fundamental questions of cell organization in the fields of membrane transport, signalling and immunological response at the molecular and design level. The approaches include molecular, cellular, biophysical, spectroscopic and bioimaging methods (including techniques such as confocal, correlative, super-resolution and Raman-based microscopy as well as electron microscopy and tomography). In addition, this expertise is used to investigate the molecular basis of cancer or rare disease development, as well as to develop screening methods for drug/target identification. These pharmacological studies are carried out in collaboration with industrial partners in the fields of cancer, rare diseases, and novel vaccine-delivery strategies. In the following the IBP main projects and organization are presented. The IBP is organized in research groups with 32 young/senior scientists expert in protein and lipid biochemistry, cell biology, biophysics, immunology, and pharmacology. Most projects are multidisciplinary and involve an array of technologies including protein and lipid analysis, bioimaging, chemo- and bio-informatics. In the area of protein biochemistry, by combining molecular biology, screening and structural studies, G. Manco aims to generate new proteins with tailor-made properties for pharmaceutical or environmental applications (Anal Chem. 2011). D. De Pascale exploits the biology of extreme environments to identify bioactive compounds active against MDR pathogens from extremophilic bacteria and fungi (EC project PharmaSea). F. Pisani aims to dissect the structural/functional relationships of enzymes and proteins involved in DNA replication in archeal and human systems (J Biol Chem 2013). In the cell biology area, A. Luini focuses on the control and coordination mechanisms of membrane trafficking, to elucidate the molecular components and design of the systems operating in the secretory pathway (Dev Cell 2014, EMBOJ 2012). The functions and the mechanisms of ADP-ribosylation are being investigated by D. Corda (PNAS 2013). Membrane fission in the Golgi requires the production of phosphatidic acid (PA) from lyso-PA by acyl-transferases activated by the protein BARS (Nat Cell Biol 2012). Corda and Luini are reconstituting membrane fission in liposomes using pure components of the BARS machinery. Among the applications of cell biology is a pharmacological approach to cystic fibrosis (Luini) through the bioinformatic identification of genes involved in the correction of cystic fibrosis defects (see D2). In lipid signaling and metabolism, G. D'Angelo investigates the sensors and effectors involved in the response to oscillations in cellular sphingolipid content (Nature 2013) and, in parallel, the significance of glycan heterogeneity in glycosphingolipids. Corda focuses on phosphoinositide metabolites for drug development in cancer and inflammation, while S. Mariggiò investigates some GPCR lysolipid ligands as biomarker in oncology. The immunology groups aim to design novel preventive/therapeutic approaches to disease. M.R. Coscia investigates the immunoglobulin structure in antartic fish as developmental model system and, by molecular dynamics simulations, the structure/dynamics of the human TCR CD3 ¶¶ dimer in lipid bilayers. D. Boraschi analyzes the activation of macrophages focusing on prevention (vaccine adjuvanticity) and therapy (inhibitors) of inflammation-based diseases, and studies the immunosafety of nanomaterials (Nanotoxicology 2014). PG. DeBerardinis develops innovative immuno-targeted strategies, focusing on delivery systems based on the filamentous bacteriophage fd, and on adoptive T cell therapy with engineered T cell receptors. C. Gianfrani investigates the immune response in the celiac disease, and in particular the role of HLA genes in determining the T cell response to gluten. As mentioned, cancer research is central at IBP. A. Colanzi investigates the molecular mechanisms of Golgi mitotic inheritance to develop strategies for inhibiting cell proliferation. The Golgi oncogenic protein Golph3 was found to cause a defect in ceramide metabolizing enzymes resulting in oncogenesis by Luini and D'Angelo. AC. De Luca applies Raman/SERS analysis in microscopy and fiber-based systems for single cell/molecule sorting and analysis (ACS Nano 2014) and develops new techniques for the recognition of cancer cells by Raman imaging. On the technology side, novel imaging, biosensing and Raman microscopy techniques are under development. Imaging techniques are used by E. Vitale to identify biomarkers of preclinical stages of neurodegenerative disorders. All research projects are associated to Training activities. Training is a key mission of IBP, and young researchers are always present in our laboratories for their 1st degree thesis, or for pre- and post-laurea stages. IBP has agreements with different Universities to host PhD students, and a formal ‘European Doctorate’ held jointly with the Second University of Naples is active since last year (coordinator: PG. De Berardinis), that is cofunded by H2020-MSCA. At IBP, young researchers enjoy an international environment, with colleagues from different countries, and with English as the official language for all activities. Weekly seminars with international guests, interest group meetings (immunology, computer science, cell biology, etc) are organized at IBP and are attended by young scientists. The seminars also include topics such as science politics, the presentation of Horizon 2020 programs, and the opportunities offered by MSCA and ERC. Courses on scientific publishing and communication are held by experts or by journal editors. An International Advisory Board visits IBP every second year and meets all the PhD students and postdocs. An Institute retreat is held every year. Notably, at IBP young researchers receive contracts in line with the rules of the European Charter and Code of Conduct for the Recruitment of Researchers (EC). (literal)
Unità organizzativa di supporto

Incoming links:


Prodotto di
Istituto esecutore
Afferisce a
Ha afferente
Descrizione di
Has part
Direttore di
Unità organizzativa di supporto in
data.CNR.it